MABE643MI

MilliporeSigma™ Rabbit anti-monomethyl Histone H3 (Lys79), Clone: RM147,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 MABE643MI-Each-of-1 In Stock ₹ 48,853.05

MABE643MI - Each of 1

₹ 48,853.05

In Stock

Quantity

1

Base Price: ₹ 48,853.05

GST (18%): ₹ 8,793.549

Total Price: ₹ 57,646.599

Antigen

monomethyl Histone H3 (Lys79)

Classification

Monoclonal

Formulation

Rabbit monoclonal in PBS with 1% BSA and 0.09% sodium azide.

Gene Symbols

H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B

Immunogen

A linear peptide corresponding to human Histone H3 monomethylated at Lys79.

Quantity

100 μg

Research Discipline

Epigenetics and Nuclear Function

Target Species

Human

Form

Purified

Applications

Western Blot

Clone

RM147

Gene Accession No.

P84243

Host Species

Rabbit

Purification Method

Protein A Purfied

Regulatory Status

RUO

Primary or Secondary

Primary

Content And Storage

Stable for one year at 2°C to 8°C from date of receipt. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Isotype

IgG

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Description

  • Specifically detects monomethyl Histone H3 (Lys79) clone: RM147 in Human samples, and it is validated for Western Blotting Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin
  • The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each)
  • Subsequently, 146 base pairs of DNA are wrapped around the octamer, forming a nucleosome, the basic subunit of chromatin
  • Histone modifications regulate DNA transcription, repair, recombination, and replication
  • The most commonly studied modifications are acetylation, phosphorylation, methylation, and ubiquitination
  • Lysine methylation occurs in three distinct states, having either one (me1), two (me2) or three (me3) methyl groups attached to the amine group of the lysine side chain
  • Methylation of Lysine 79 in Histone 3 acts as a marker of inactive chromatin regions
  • Methylation by Dot1 methylase on lysine-79 (Lys79) of Histone H3 is criticial for transcriptional silencing, and it is thought that silencing proteins such as Sir3 function by blocking Dot1 methylation.

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Img

MilliporeSigma™

MABE643MI

--


Antigen:
monomethyl Histone H3 (Lys79)

Classification:
Monoclonal

Formulation:
Rabbit monoclonal in PBS with 1% BSA and 0.09% sodium azide.

Gene Symbols:
H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B

Immunogen:
A linear peptide corresponding to human Histone H3 monomethylated at Lys79.

Quantity:
100 μg

Research Discipline:
Epigenetics and Nuclear Function

Target Species:
Human

Form:
Purified

Applications:
Western Blot

Clone:
RM147

Gene Accession No.:
P84243

Host Species:
Rabbit

Purification Method:
Protein A Purfied

Regulatory Status:
RUO

Primary or Secondary:
Primary

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Isotype:
IgG

Img

MilliporeSigma™

MABE644

--


Antigen:
Cre Recombinase

Classification:
Monoclonal

Formulation:
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Symbols:
__

Immunogen:
GST-tagged recombinant Cre lacking the N-terminal region sequence.

Quantity:
100 μL

Research Discipline:
Epigenetics & Nuclear Function

Target Species:
All species

Form:
Purified

Applications:
Western Blot

Clone:
5B4.1

Gene Accession No.:
P06956

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.

Isotype:
IgG1 κ

Img

MilliporeSigma™

MABE645MI

--


Antigen:
acetyl-Histone H3 (Lys9)

Classification:
Monoclonal

Formulation:
Rabbit monoclonal in PBS with 1% BSA and 0.09% sodium azide.

Gene Symbols:
H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B

Immunogen:
A linear peptide corresponding to human Histone H3 acetylated at Lys9.

Quantity:
100 μg

Research Discipline:
Epigenetics and Nuclear Function

Target Species:
Human

Form:
Purified

Applications:
Western Blot

Clone:
RM161

Gene Accession No.:
P84243

Host Species:
Rabbit

Purification Method:
Protein A Purfied

Regulatory Status:
RUO

Primary or Secondary:
Primary

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Isotype:
IgG

Img

MilliporeSigma™

MABE647MI

--


Antigen:
acetyl-Histone H3 (Lys27)

Classification:
Monoclonal

Formulation:
Rabbit monoclonal in PBS with 1% BSA and 0.09% sodium azide

Gene Symbols:
H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B

Immunogen:
A linear peptide corresponding to human Histone H3 acetylated at Lys27.

Quantity:
100 μg

Research Discipline:
Epigenetics and Nuclear Function

Target Species:
Human

Form:
Purified

Applications:
Western Blot

Clone:
RM172

Gene Accession No.:
P84243

Host Species:
Rabbit

Purification Method:
Protein A Purfied

Regulatory Status:
RUO

Primary or Secondary:
Primary

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

Isotype:
IgG