PCBP2 (hnRNP E2), Mouse anti-Human, Clone: PC 81-1, Millipore Sigma™

Description

• Anti-PCBP2 (hnRNP E2), clone PC81-1, Cat
• No
• MABF2122, is a mouse monoclonal antibody that detects Poly(rC)-binding protein 2 and has been tested for use in Immunocytochemistry and Western Blotting
• Poly(rC)-binding protein 2 (UniProt: Q15366; also known as Alpha-CP2, Heterogeneous nuclear ribonucleoprotein E2, hnRNP E2) is encoded by the PCBP2 gene (Gene ID: 5094) in human
• PCBP2 belongs to a class of cellular proteins that bind to poly(C) stretches of both RNA and DNA and has been detected in all tissues studied
• PCBP2 shuttles between the nucleus and cytoplasm and exerts its impact on RNA processing and mRNA expression through sequence-specific interactions with C-rich determinants within target mRNAs
• It acts as an important mediator of multiple processes, including replication of viruses with gastrointestinal and hepatic tropism, hepatic collagen synthesis, globin expression, and cellular proliferation
• PCBP2 is shown to negatively regulate cellular antiviral responses mediated by mitochondrial antiviral-signaling protein (MAVS) signaling and acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, thereby triggering MAVS ubiquitination and degradation
• Together with PCBP1, it is shown to function as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication
• It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA
• PCBP2 contains three K-homologous (KH) domains that mediates poly(C) binding
• Eight different isoforms of PCBP2 have been described that are produced by alternative splicing
• (Ref.: Ghanem, LR et al
• (2014)
• Gene Exp
• Patterns 14(2); 78-87; Sean, P., et al
• (2008)
• Virology
• Virology
• 378(2); 243-253).