MABN247525
NMDAR2B, Mouse anti-Human, Mouse, Rat, Clone: 11D1, Millipore Sigma™
Manufacturer: Fischer Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN247525-Each-of-1 | In Stock | ₹ 16,456.61 |
MABN247525 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
NMDAR2B
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
GRIN2B;NMDAR2B
Immunogen
Full length purified human Glutamate receptor ionotropic, NMDA 2B (NMDAR2B).
Quantity
25 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_000825
Target Species
Human, Mouse, Rat
Form
Purified
Applications
Western Blot
Clone
11D1
Dilution
Western Blotting Analysis: A representative lot detected NMDAR2B in Western Blotting applications (Lu, W., et. al. (2017). Science. 355(6331)). Western Blotting Analysis: 4μg/mL from a representative lot detected NMDAR2B in mouse brain tissue lysate.
Gene Alias
Glutamate receptor ionotropic NMDA 2B;GluN2B;Glutamate [NMDA] receptor subunit epsilon-2;N-methyl D-aspartate receptor subtype 2B;NR2B;N-methyl-D-aspartate receptor subunit 3;NR3;hNR3
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 11D1 is a mouse monoclonal antibody that specifically detects NMDAR2B.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Anti-NMDAR2B, clone 11D1, Cat
- No
- MABN2475, is a highly specific mouse monoclonal antibody that targets Glutamate receptor ionotropic, NMDA 2B and has been tested for use in Western Blotting
- Glutamate receptor ionotropic, NMDA2B (UniProt: Q13224; also known GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, N-methyl-D-aspartate receptor subunit 3, NR3, hNR3) is encoded by the GRIN2B (also known as NMDAR2B) gene (Gene ID: 2904) in human
- NMDA receptor complexes are ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium
- They are involved in long-term potentiation and neuronal plasticity and regulate the number of nerve cells during development
- However, over-stimulation NMDA receptors can lead to neuronal degeneration
- NMDAR2B is a heterotetrameric, multi-pass membrane protein that is synthesized with a signal peptide (aa 1-26), which is subsequently cleaved off in the mature form
- The heterotetrameric channel is composed of two zeta subunits and two epsilon subunits, but can also form channels that contain at least one zeta subunit and at least one epsilon subunit
- Activation of NMDA 2B channel requires binding of glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by magnesium ions
- NMDA 2B is reported to be phosphorylated at Ser1303 by DAPK1 that enhances its channel activity allowing injurious Ca2+ influx that results in neuronal death
- Mutations in NMDAR2B have been linked to early infantile epileptic encephalopathy that is characterized by refractory seizures and neurodevelopmental impairment
- Some mutations are also known to cause mental retardation with or without seizures.
Compare Similar Items
Show Difference
Antigen: NMDAR2B
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: GRIN2B;NMDAR2B
Immunogen: Full length purified human Glutamate receptor ionotropic, NMDA 2B (NMDAR2B).
Quantity: 25 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_000825
Target Species: Human, Mouse, Rat
Form: Purified
Applications: Western Blot
Clone: 11D1
Dilution: Western Blotting Analysis: A representative lot detected NMDAR2B in Western Blotting applications (Lu, W., et. al. (2017). Science. 355(6331)). Western Blotting Analysis: 4μg/mL from a representative lot detected NMDAR2B in mouse brain tissue lysate.
Gene Alias: Glutamate receptor ionotropic NMDA 2B;GluN2B;Glutamate [NMDA] receptor subunit epsilon-2;N-methyl D-aspartate receptor subtype 2B;NR2B;N-methyl-D-aspartate receptor subunit 3;NR3;hNR3
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 11D1 is a mouse monoclonal antibody that specifically detects NMDAR2B.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
NMDAR2B
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
GRIN2B;NMDAR2B
Immunogen:
Full length purified human Glutamate receptor ionotropic, NMDA 2B (NMDAR2B).
Quantity:
25 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_000825
Target Species:
Human, Mouse, Rat
Form:
Purified
Applications:
Western Blot
Clone:
11D1
Dilution:
Western Blotting Analysis: A representative lot detected NMDAR2B in Western Blotting applications (Lu, W., et. al. (2017). Science. 355(6331)). Western Blotting Analysis: 4μg/mL from a representative lot detected NMDAR2B in mouse brain tissue lysate.
Gene Alias:
Glutamate receptor ionotropic NMDA 2B;GluN2B;Glutamate [NMDA] receptor subunit epsilon-2;N-methyl D-aspartate receptor subtype 2B;NR2B;N-methyl-D-aspartate receptor subunit 3;NR3;hNR3
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 11D1 is a mouse monoclonal antibody that specifically detects NMDAR2B.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: Keratan Sulfate
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: __
Immunogen: Proteoglycan core protein isolated after chondroitinase ABC digestion of human articular cartilage proteoglycan monomer.
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Applications: ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot
Clone: 5-D-4
Dilution: __
Gene Alias: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
Keratan Sulfate
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
__
Immunogen:
Proteoglycan core protein isolated after chondroitinase ABC digestion of human articular cartilage proteoglycan monomer.
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot
Clone:
5-D-4
Dilution:
__
Gene Alias:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: Keratan Sulfate
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: __
Immunogen: Proteoglycan core protein isolated after chondroitinase ABC digestion of human articular cartilage proteoglycan monomer.
Quantity: 25 μL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Applications: ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot
Clone: 5-D-4
Dilution: __
Gene Alias: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
Keratan Sulfate
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
__
Immunogen:
Proteoglycan core protein isolated after chondroitinase ABC digestion of human articular cartilage proteoglycan monomer.
Quantity:
25 μL
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Western Blot
Clone:
5-D-4
Dilution:
__
Gene Alias:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: ErbB4
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified rabbit monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: Erbb4;Mer4
Immunogen: GST-tagged recombinant protein corresponding to 204 amino acids from the C-terminal region of murine Receptor tyrosine-protein kinase erbB-4.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_034284.1
Target Species: Mouse
Form: Purified
Applications: ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: mab10
Dilution: Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution from a representative lot detected ErbB4 in mouse embryo tissue sections.Western Blotting Analysis: A representative lot detected ErbB4 in Western Blotting applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).ELISA Analysis: A representative lot detected ErbB4 in ELISA applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).Immunohistochemistry Analysis: A representative lot detected ErbB4 in Immunohistochemistry applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).Immunoprecipitation Analysis: A representative lot immunoprecipitated ErbB4 in Immunoprecipitation applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).
Gene Alias: Receptor tyrosine-protein kinase erbB-4;Proto-oncogene-like protein c-ErbB-4
Host Species: Rabbit
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone mAB10 is a rabbit monoclonal antibody that detects mouse Receptor tyrosine-protein kinase erbB-4. It targets an epitope with in the C-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG
Antigen:
ErbB4
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified rabbit monoclonal antibody IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
Erbb4;Mer4
Immunogen:
GST-tagged recombinant protein corresponding to 204 amino acids from the C-terminal region of murine Receptor tyrosine-protein kinase erbB-4.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_034284.1
Target Species:
Mouse
Form:
Purified
Applications:
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
mab10
Dilution:
Immunohistochemistry (Paraffin) Analysis: A 1:250 dilution from a representative lot detected ErbB4 in mouse embryo tissue sections.Western Blotting Analysis: A representative lot detected ErbB4 in Western Blotting applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).ELISA Analysis: A representative lot detected ErbB4 in ELISA applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).Immunohistochemistry Analysis: A representative lot detected ErbB4 in Immunohistochemistry applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).Immunoprecipitation Analysis: A representative lot immunoprecipitated ErbB4 in Immunoprecipitation applications (Vullhorst, D., et. al. (2009). J Neurosci. 29(39):12255-64).
Gene Alias:
Receptor tyrosine-protein kinase erbB-4;Proto-oncogene-like protein c-ErbB-4
Host Species:
Rabbit
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone mAB10 is a rabbit monoclonal antibody that detects mouse Receptor tyrosine-protein kinase erbB-4. It targets an epitope with in the C-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG