MABS181925
OTUD3, Mouse anti-Human, Clone: 12A6.1, Millipore Sigma™
Manufacturer: MilliporeSigma
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS181925-Each-of-1 | In Stock | ₹ 16,456.61 |
MABS181925 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
OTUD3
Classification
Monoclonal
Conjugate
Unconjugated
Gene Alias
OTU domain-containing protein 3;EC 3.4.19.12
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
12A6.1
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
OTUD3;KIAA0459
Immunogen
GST/His-tagged recombinant fragment corresponding to 115 amino acids from the C-terminal half of human OTU domain-containing protein 3.
Quantity
25 μg
Research Discipline
Signaling
Test Specificity
Clone 12A6.1 detects OTU domain-containing protein 3 in human cells. It iargets an epitope within 115 amino acids from the C-terminal region.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Anti-OTUD3, clone 12A6.1, Cat
- No
- MABS1819, is a mouse monoclonal antibody that detects OTUD3 in human cells and has been tested for use in Western Blotting
- OTU domain-containing protein 3 (UniProt: Q5T2D3; also known as EC: 3.4.19.12, OTUD3) is encoded by the OTUD3 (also known as KIAA0459) gene (Gene ID: 23252) in human
- OTUD3 is a cytoplasmic deubiquitinating enzyme that hydrolyzes Lys-6- and Lys-11-linked polyubiquitin and is reported to hydrolyze heterotypic (mixed and branched) and homotypic chains
- It has an OUT domain (aa 65-189) and a UBA-like domain (aa 230-270)
- Its specificity is given by the S1' ubiquitin-binding site within the OTU domain composed of the Cys-, His- and Variable-loops
- The UBA-like domain has no effect on ubiquitin hydrolysis
- It displays a thiol-dependent ubiquitin-specific protease activity
- It is reported to regulate PTEN stability and suppresses tumorigenesis
- OTUD3 transgenic mice exhibit higher levels of the PTEN and are shown to be less prone to tumorigenesis
- OTUD3 is believed to regulate PTEN in a manner, which is dependent on its DUB activity
- The catalytically inactive mutant C76A does not upregulate PTEN and may even have a downregulating effect
- It can remove Lys-6, Lys-11, Lys-27, and Lys-48 types of ubiquitin chain on PTEN
- (Ref.: Yuan, L., et al (2015)
- Nat
- Cell Biol
- 17(9); 1169-1181).
Compare Similar Items
Show Difference
Antigen: OTUD3
Classification: Monoclonal
Conjugate: Unconjugated
Gene Alias: OTU domain-containing protein 3;EC 3.4.19.12
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 12A6.1
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: OTUD3;KIAA0459
Immunogen: GST/His-tagged recombinant fragment corresponding to 115 amino acids from the C-terminal half of human OTU domain-containing protein 3.
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: Clone 12A6.1 detects OTU domain-containing protein 3 in human cells. It iargets an epitope within 115 amino acids from the C-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
OTUD3
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Alias:
OTU domain-containing protein 3;EC 3.4.19.12
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
12A6.1
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
OTUD3;KIAA0459
Immunogen:
GST/His-tagged recombinant fragment corresponding to 115 amino acids from the C-terminal half of human OTU domain-containing protein 3.
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
Clone 12A6.1 detects OTU domain-containing protein 3 in human cells. It iargets an epitope within 115 amino acids from the C-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: __
Classification: __
Conjugate: __
Gene Alias: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Applications: __
Clone: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Test Specificity: __
Content And Storage: __
Isotype: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene Alias:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Applications:
__
Clone:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__
Antigen: SHMT
Classification: Monoclonal
Conjugate: Unconjugated
Gene Alias: Serine hydroxymethyltransferase mitochondrial;EC: 2.1.2.1;SHMT;Glycine hydroxymethyltransferase;Serine methylase
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 4D2.1
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: SHMT2
Immunogen: GST/His-tagged recombinant fragment corresponding to 107 amino acids from the C-terminal half of human mitochondrial Serine hydroxymethyltransferase.
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: Clone 4D2.1 detects human mitochondrial Serine hydroxymethyltransferase. It targets an epitope within 107 amino acids from the C-terminal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
SHMT
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Alias:
Serine hydroxymethyltransferase mitochondrial;EC: 2.1.2.1;SHMT;Glycine hydroxymethyltransferase;Serine methylase
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
4D2.1
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
SHMT2
Immunogen:
GST/His-tagged recombinant fragment corresponding to 107 amino acids from the C-terminal half of human mitochondrial Serine hydroxymethyltransferase.
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
Clone 4D2.1 detects human mitochondrial Serine hydroxymethyltransferase. It targets an epitope within 107 amino acids from the C-terminal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: LATS1
Classification: Monoclonal
Conjugate: Unconjugated
Gene Alias: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Western Blot, Immunohistochemistry (Paraffin)
Clone: 9A3.1
Formulation: __
Gene Symbols: LATS1,WARTS
Immunogen: GST/His-tagged recombinant fragment corresponding to 116 amino acids from the N-terminal half of human Serine/threonine-protein kinase LATS1.
Quantity: 100 μg
Research Discipline: Signaling
Test Specificity: Clone 9A3.1 specifically detects Serine/threonine protein kinase LATS1 in human cells. It targets an epitope within 116 amino acids from the N-termnal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
LATS1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Alias:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Western Blot, Immunohistochemistry (Paraffin)
Clone:
9A3.1
Formulation:
__
Gene Symbols:
LATS1,WARTS
Immunogen:
GST/His-tagged recombinant fragment corresponding to 116 amino acids from the N-terminal half of human Serine/threonine-protein kinase LATS1.
Quantity:
100 μg
Research Discipline:
Signaling
Test Specificity:
Clone 9A3.1 specifically detects Serine/threonine protein kinase LATS1 in human cells. It targets an epitope within 116 amino acids from the N-termnal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ