MABS182225
SHMT, Mouse anti-Human, Clone: 4D2.1, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS182225-Each-of-1 | In Stock | ₹ 16,456.61 |
MABS182225 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
SHMT
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
SHMT2
Immunogen
GST/His-tagged recombinant fragment corresponding to 107 amino acids from the C-terminal half of human mitochondrial Serine hydroxymethyltransferase.
Quantity
25 μg
Research Discipline
Signaling
Test Specificity
Clone 4D2.1 detects human mitochondrial Serine hydroxymethyltransferase. It targets an epitope within 107 amino acids from the C-terminal half.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
4D2.1
Dilution
Immunohistochemistry Analysis: A 1:50-250 dilution of this antibody from a representative lot detected SHMT in human colon, human liver, and human pancreas tissue sections.Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected SHMT in Jurkat cell lysate.
Gene Alias
Serine hydroxymethyltransferase mitochondrial;EC: 2.1.2.1;SHMT;Glycine hydroxymethyltransferase;Serine methylase
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Description
- Anti-SHMT, clone 4D2.1, Cat
- No
- MABS1822, is a mouse monoclonal antibody that detects mitochondrial Serine hydroxymethyltransferase and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting
- Serine hydroxymethyltransferase, mitochondrial (UniProt: P34897; also known as EC: 2.1.2.1, SHMT, Glycine hydroxymethyltransferase, Serine methylase) is encoded by the SHMT2 gene (Gene ID: 6472) in human
- SHMT is involved in the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism
- Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA
- SHMT catalyzes the reversible conversion of serine and glycine
- It uses pyridoxal-5 -phosphate as a cofactor
- SHMT is synthesized with a transit peptide (aa 1-29) that is needed for its mitochondrial translocation
- In eukaryotes two forms of SHMT have been reported: cytosolic and mitochondrial
- In the presence of bound pyridoxal 5'-phosphate it is present in a homotetrameric form and in the absence of pyridoxal 5'-phosphate it exists as a homodimer
- Pyridoxal 5'-phosphate binding mediates an important conformation change, which is essential for its tetramerization
- Three isoforms of SHMT have been reported that are produced by alternative splicing.
Compare Similar Items
Show Difference
Antigen: SHMT
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: SHMT2
Immunogen: GST/His-tagged recombinant fragment corresponding to 107 amino acids from the C-terminal half of human mitochondrial Serine hydroxymethyltransferase.
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: Clone 4D2.1 detects human mitochondrial Serine hydroxymethyltransferase. It targets an epitope within 107 amino acids from the C-terminal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 4D2.1
Dilution: Immunohistochemistry Analysis: A 1:50-250 dilution of this antibody from a representative lot detected SHMT in human colon, human liver, and human pancreas tissue sections.Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected SHMT in Jurkat cell lysate.
Gene Alias: Serine hydroxymethyltransferase mitochondrial;EC: 2.1.2.1;SHMT;Glycine hydroxymethyltransferase;Serine methylase
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
SHMT
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
SHMT2
Immunogen:
GST/His-tagged recombinant fragment corresponding to 107 amino acids from the C-terminal half of human mitochondrial Serine hydroxymethyltransferase.
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
Clone 4D2.1 detects human mitochondrial Serine hydroxymethyltransferase. It targets an epitope within 107 amino acids from the C-terminal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
4D2.1
Dilution:
Immunohistochemistry Analysis: A 1:50-250 dilution of this antibody from a representative lot detected SHMT in human colon, human liver, and human pancreas tissue sections.Western Blotting Analysis: A 1:1,000 dilution from a representative lot detected SHMT in Jurkat cell lysate.
Gene Alias:
Serine hydroxymethyltransferase mitochondrial;EC: 2.1.2.1;SHMT;Glycine hydroxymethyltransferase;Serine methylase
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: LATS1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: __
Gene Symbols: LATS1,WARTS
Immunogen: GST/His-tagged recombinant fragment corresponding to 116 amino acids from the N-terminal half of human Serine/threonine-protein kinase LATS1.
Quantity: 100 μg
Research Discipline: Signaling
Test Specificity: Clone 9A3.1 specifically detects Serine/threonine protein kinase LATS1 in human cells. It targets an epitope within 116 amino acids from the N-termnal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Western Blot, Immunohistochemistry (Paraffin)
Clone: 9A3.1
Dilution: __
Gene Alias: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
LATS1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
LATS1,WARTS
Immunogen:
GST/His-tagged recombinant fragment corresponding to 116 amino acids from the N-terminal half of human Serine/threonine-protein kinase LATS1.
Quantity:
100 μg
Research Discipline:
Signaling
Test Specificity:
Clone 9A3.1 specifically detects Serine/threonine protein kinase LATS1 in human cells. It targets an epitope within 116 amino acids from the N-termnal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Western Blot, Immunohistochemistry (Paraffin)
Clone:
9A3.1
Dilution:
__
Gene Alias:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: LATS1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: __
Gene Symbols: LATS1,WARTS
Immunogen: GST/His-tagged recombinant fragment corresponding to 116 amino acids from the N-terminal half of human Serine/threonine-protein kinase LATS1.
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: Clone 9A3.1 specifically detects Serine/threonine protein kinase LATS1 in human cells. It targets an epitope within 116 amino acids from the N-termnal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Western Blot, Immunohistochemistry (Paraffin)
Clone: 9A3.1
Dilution: __
Gene Alias: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
LATS1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
LATS1,WARTS
Immunogen:
GST/His-tagged recombinant fragment corresponding to 116 amino acids from the N-terminal half of human Serine/threonine-protein kinase LATS1.
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
Clone 9A3.1 specifically detects Serine/threonine protein kinase LATS1 in human cells. It targets an epitope within 116 amino acids from the N-termnal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Western Blot, Immunohistochemistry (Paraffin)
Clone:
9A3.1
Dilution:
__
Gene Alias:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: LOX-1
Classification: Monoclonal
Conjugate: __
Formulation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: OLR1; CLEC8A; LOX1
Immunogen: GST-tagged recombinant protein corresponding to human LOX-1.
Quantity: 100 μg
Research Discipline: Signaling
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2a κ
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone: 9E12.1
Dilution: __
Gene Alias: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
LOX-1
Classification:
Monoclonal
Conjugate:
__
Formulation:
Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
OLR1; CLEC8A; LOX1
Immunogen:
GST-tagged recombinant protein corresponding to human LOX-1.
Quantity:
100 μg
Research Discipline:
Signaling
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2a κ
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone:
9E12.1
Dilution:
__
Gene Alias:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified