MABS191025
Signal peptide peptidase-like 3, Mouse anti-Human, Clone: 7F9, Millipore Sigma™
Manufacturer: MilliporeSigma
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS191025-Each-of-1 | In Stock | ₹ 16,456.61 |
MABS191025 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
Signal peptide peptidase-like 3
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
SPPL3;IMP2
Immunogen
KLH-conjugated linear peptide corresponding to 15 amino acids from the C-terminal half of human Signal peptide peptidase-like 3.
Quantity
25 μg
Research Discipline
Signaling
Test Specificity
Clone 7F9 detects Signal peptide peptidase-like 3 in human cells. it targets an epitope within 15 amino acids from the C-terminal half. Immunogen sequence is conserved in all three isoforms.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1
Applications
Immunoprecipitation, Western Blot
Clone
7F9
Dilution
Western Blotting Analysis: A representative lot detected Signal peptide peptidase-like 3 in Western Blotting applications (Voss, M., et. al. (2012). J Biol Chem. 287(52):43401-9; Voss, M., et. al. (2014). EMBO J. 33(24):2890-905; Fleck, D., et. al. (2016). J Biol Chem. 291(1):318-33).Immunoprecipitation Analysis: A representative lot detected Signal peptide peptidase-like 3 in Immunoprecipitation applications (Voss, M., et. al. (2012). J Biol Chem. 287(52):43401-9).
Gene Alias
Signal peptide peptidase-like 3;SPP-like 3;Intramembrane protease 2;IMP-2;Presenilin homologous protein 1;PSH1;Presenilin-like protein 4
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Description
- Anti-Signal peptide peptidase-like 3, clone 7F9, Cat
- No
- MABS1910, is a mouse monoclonal antibody that detects Signal peptide peptidase-like 3 and has been tested for use in Immunoprecipitation and Western Blotting
- Signal peptide peptidase-like 3 (UniProt: Q8TCT6; also known as SPP-like 3, Intramembrane protease 2, IMP-2, Presenilin homologous protein 1, PSH1, Presenilin-like protein 4, SPPL3) is encoded by the SPPL3 (also known as IMP2) gene (Gene ID: 121665) in human
- SPPL3 is a multi-pass transmembrane protein that is shown to be widely expressed and is highly conserved in multicellular eukaryotes
- Three isoforms of SPPL3 have been described that are produced by alternative splicing
- It is a member of the intramembrane-cleaving GxGD proteases
- It acts as an intramembrane protease that cleaves type II membrane protein substrates in or close to their luminal transmembrane domain boundaries
- It can also act as a sheddase by mediating the proteolytic release and secretion of active site-containing ectodomains of glycan-modifying glycosidases and glycosyltransferases
- It is also shown to catalyze the intramembrane cleavage of the envelope glycoprotein gp130 and/or the leader peptide gp18LP of the simian foamy virus independent of prior ectodomain shedding by furin or furin-like proprotein convertase-mediated cleavage proteolysis
- The first transmembrane domain of SPPL3 may act as a type I signal anchor
- SPPL3 also contains a PAL motif (aa 342-344) that is required for normal active site conformation.
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Antigen: Signal peptide peptidase-like 3
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: SPPL3;IMP2
Immunogen: KLH-conjugated linear peptide corresponding to 15 amino acids from the C-terminal half of human Signal peptide peptidase-like 3.
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: Clone 7F9 detects Signal peptide peptidase-like 3 in human cells. it targets an epitope within 15 amino acids from the C-terminal half. Immunogen sequence is conserved in all three isoforms.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Applications: Immunoprecipitation, Western Blot
Clone: 7F9
Dilution: Western Blotting Analysis: A representative lot detected Signal peptide peptidase-like 3 in Western Blotting applications (Voss, M., et. al. (2012). J Biol Chem. 287(52):43401-9; Voss, M., et. al. (2014). EMBO J. 33(24):2890-905; Fleck, D., et. al. (2016). J Biol Chem. 291(1):318-33).Immunoprecipitation Analysis: A representative lot detected Signal peptide peptidase-like 3 in Immunoprecipitation applications (Voss, M., et. al. (2012). J Biol Chem. 287(52):43401-9).
Gene Alias: Signal peptide peptidase-like 3;SPP-like 3;Intramembrane protease 2;IMP-2;Presenilin homologous protein 1;PSH1;Presenilin-like protein 4
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
Signal peptide peptidase-like 3
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
SPPL3;IMP2
Immunogen:
KLH-conjugated linear peptide corresponding to 15 amino acids from the C-terminal half of human Signal peptide peptidase-like 3.
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
Clone 7F9 detects Signal peptide peptidase-like 3 in human cells. it targets an epitope within 15 amino acids from the C-terminal half. Immunogen sequence is conserved in all three isoforms.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1
Applications:
Immunoprecipitation, Western Blot
Clone:
7F9
Dilution:
Western Blotting Analysis: A representative lot detected Signal peptide peptidase-like 3 in Western Blotting applications (Voss, M., et. al. (2012). J Biol Chem. 287(52):43401-9; Voss, M., et. al. (2014). EMBO J. 33(24):2890-905; Fleck, D., et. al. (2016). J Biol Chem. 291(1):318-33).Immunoprecipitation Analysis: A representative lot detected Signal peptide peptidase-like 3 in Immunoprecipitation applications (Voss, M., et. al. (2012). J Biol Chem. 287(52):43401-9).
Gene Alias:
Signal peptide peptidase-like 3;SPP-like 3;Intramembrane protease 2;IMP-2;Presenilin homologous protein 1;PSH1;Presenilin-like protein 4
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: Mitochondrial Pyruvate Carrier 2 (BRP44)
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: MCP2;BRP44
Immunogen: A linear peptide corresponding to 10 amino acids from the internal region of human mitochondrial pyruvate carrier 2 protein.
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: This mouse monoclonal antibody detects Mitochondrial Pyruvate carrrier Protein 2 in human and mouse cells. It targets an epitope within 10 amino acids from the internal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Applications: Immunoprecipitation, Western Blot
Clone: __
Dilution: Western Blotting Analysis: 1μg/mL from a representative lot detected Mitochondrial Pyruvate Carrier 2 (BRP44) in mouse heart and mouse liver tissue lysates. Immunoprecipitation Analysis: A 1:1,000 dilution from a representative lot immunoprecipitated Mitochondrial Pyruvate Carrier 2 (BRP44) in mouse liver mitoplasts (Courtesy of Prof. Jean-Claude Martinou, Ph.D., University of Geneva, Switzerland).. Western Blotting Analysis: 4 μg/mL from a represenetative lot detected Mitochondrial Pyruvate Carrier 2 (BRP44) in mouse pancreas tissue lysate. Western Blotting Analysis: A representative lot detected Mitochondrial Pyruvate Carrier 2 (BRP44) in Western Blotting applications (Compan, V., et. al. (2015). Mol Cell. 59(3):491-501; Vanderperre, B., et. al. (2016). PLoS Genet. 12(5):e1006056).
Gene Alias: Mitochondrial pyruvate carrier 2;Brain protein 44;BRP44
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Purified
Antigen:
Mitochondrial Pyruvate Carrier 2 (BRP44)
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
MCP2;BRP44
Immunogen:
A linear peptide corresponding to 10 amino acids from the internal region of human mitochondrial pyruvate carrier 2 protein.
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
This mouse monoclonal antibody detects Mitochondrial Pyruvate carrrier Protein 2 in human and mouse cells. It targets an epitope within 10 amino acids from the internal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1
Applications:
Immunoprecipitation, Western Blot
Clone:
__
Dilution:
Western Blotting Analysis: 1μg/mL from a representative lot detected Mitochondrial Pyruvate Carrier 2 (BRP44) in mouse heart and mouse liver tissue lysates. Immunoprecipitation Analysis: A 1:1,000 dilution from a representative lot immunoprecipitated Mitochondrial Pyruvate Carrier 2 (BRP44) in mouse liver mitoplasts (Courtesy of Prof. Jean-Claude Martinou, Ph.D., University of Geneva, Switzerland).. Western Blotting Analysis: 4 μg/mL from a represenetative lot detected Mitochondrial Pyruvate Carrier 2 (BRP44) in mouse pancreas tissue lysate. Western Blotting Analysis: A representative lot detected Mitochondrial Pyruvate Carrier 2 (BRP44) in Western Blotting applications (Compan, V., et. al. (2015). Mol Cell. 59(3):491-501; Vanderperre, B., et. al. (2016). PLoS Genet. 12(5):e1006056).
Gene Alias:
Mitochondrial pyruvate carrier 2;Brain protein 44;BRP44
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Purified
Antigen: __
Classification: __
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Antigen: c-Met
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse IgG1 in PBS without preservatives.
Gene Symbols: __
Immunogen: His-tagged recombinant human c-Met alpha chain (Wong, J.S., et al. (2013). Oncotarget. 4(7):1019-1036).
Quantity: 100 μL
Research Discipline: Signaling
Test Specificity: Clone seeMet 13 bound strongly to native c-Met by flow cytometry, while exhibiting low reactivity and specificity towards denatured c-Met by Western blotting (Wong, J.S., et al. (2013). Oncotarget. 4(7):1019-1036).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG1 κ
Applications: Immunocytochemistry, Immunoprecipitation, Inhibition Assays
Clone: seeMet 13
Dilution: __
Gene Alias: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
c-Met
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse IgG1 in PBS without preservatives.
Gene Symbols:
__
Immunogen:
His-tagged recombinant human c-Met alpha chain (Wong, J.S., et al. (2013). Oncotarget. 4(7):1019-1036).
Quantity:
100 μL
Research Discipline:
Signaling
Test Specificity:
Clone seeMet 13 bound strongly to native c-Met by flow cytometry, while exhibiting low reactivity and specificity towards denatured c-Met by Western blotting (Wong, J.S., et al. (2013). Oncotarget. 4(7):1019-1036).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Immunoprecipitation, Inhibition Assays
Clone:
seeMet 13
Dilution:
__
Gene Alias:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified