MABS1916MI
MilliporeSigma™ c-Met, Mouse, Unlabeled, Clone: seeMet 13,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1916MI-Each-of-1 | In Stock | ₹ 37,453.03 |
MABS1916MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,453.03
GST (18%): ₹ 6,741.545
Total Price: ₹ 44,194.575
Antigen
c-Met
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1 in PBS without preservatives.
Gene Accession No.
P08581
Immunogen
His-tagged recombinant human c-Met alpha chain (Wong, J.S., et al. (2013). Oncotarget. 4(7):1019-1036).
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_000236
Target Species
Human
Form
Purified
Applications
Immunocytochemistry, Immunoprecipitation, Inhibition Assays
Clone
seeMet 13
Conjugate
Unconjugated
Gene
MET, AUTS9, HCC, RCCP
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone seeMet 13 bound strongly to native c-Met by flow cytometry, while exhibiting low reactivity and specificity towards denatured c-Met by Western blotting (Wong, J.S., et al. (2013). Oncotarget. 4(7):1019-1036).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype
IgG1 κ
Related Products
Description
- Hepatocyte growth factor receptor (EC 2.7.10.1; UniProt P08581; also known as HGF receptor, HGF/SF receptor, Proto-oncogene c-Met, Scatter factor receptor, SF receptor, Tyrosine-protein kinase Met) is encoded by the MET (also known as AUTS9, HCC, RCCP) gene (Gene ID 4233) in human
- HGF receptor or c-Met is initially produced as a 1390-a.a
- precursor protein with an N-terminal signal peptide, postranslational proteolytic cleavage yields the mature tyrosine kinase receptor composed of an extracellular alpha chain (a.a
- 25-307) linked via a disulfide bond to a transmembrane beta chain with an extracellular domain (a.a
- 308-932), transmembrane helix (a.a
- 933-955), and a cytoplasmic domain (a.a
- 956-1390)
- The alpha-chain and the extracellular portion of beta-chain form the Sema domain that mediates receptor dimerization and ligand binding
- The cytoplasmic portion of beta-chain contains the kinase domain (a.a
- 1078-1345) and a C-terminal tail that contains a docking region (a.a
- 1212-1390) for effector and adapter proteins essential for downstream signaling
- Hepatocyte growth factor (HGF) is the only known c-Met ligand
- HGF binding induces c-Met dimerization and autophosphorylation on Y1230, Y1234 and Y1235, leading to a conformation change and further phosphorylation on Y1349 and Y1356, making C-terminal tail docking region available for adaptor and signalling molecules
- c-Met mediates a wide-range of biological activities, including cell proliferation, motility, angiogenesis and morphogenesis, and is an attractive target for cancer therapy
- Aberrant c-Met activation/signalling promotes cancer cell proliferation and is associated with poor prognosis in various human cancers
- Upregulated c-Met expression is also known to cause resistance against HER2, EGFR and B-RAF inhibitory drugs in cancer treatment.
Compare Similar Items
Show Difference
Antigen: c-Met
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG1 in PBS without preservatives.
Gene Accession No.: P08581
Immunogen: His-tagged recombinant human c-Met alpha chain (Wong, J.S., et al. (2013). Oncotarget. 4(7):1019-1036).
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_000236
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Immunoprecipitation, Inhibition Assays
Clone: seeMet 13
Conjugate: Unconjugated
Gene: MET, AUTS9, HCC, RCCP
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone seeMet 13 bound strongly to native c-Met by flow cytometry, while exhibiting low reactivity and specificity towards denatured c-Met by Western blotting (Wong, J.S., et al. (2013). Oncotarget. 4(7):1019-1036).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG1 κ
Antigen:
c-Met
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG1 in PBS without preservatives.
Gene Accession No.:
P08581
Immunogen:
His-tagged recombinant human c-Met alpha chain (Wong, J.S., et al. (2013). Oncotarget. 4(7):1019-1036).
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000236
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Immunoprecipitation, Inhibition Assays
Clone:
seeMet 13
Conjugate:
Unconjugated
Gene:
MET, AUTS9, HCC, RCCP
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone seeMet 13 bound strongly to native c-Met by flow cytometry, while exhibiting low reactivity and specificity towards denatured c-Met by Western blotting (Wong, J.S., et al. (2013). Oncotarget. 4(7):1019-1036).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG1 κ
Antigen: __
Classification: __
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Applications: __
Clone: __
Conjugate: __
Gene: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Isotype: __
Antigen:
__
Classification:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Form:
__
Applications:
__
Clone:
__
Conjugate:
__
Gene:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__
Antigen: RIP140
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: GST-tagged recombinant fragment corresponding to 178 amino acids from the N-terminal half of human Nuclear receptor-interacting protein 1 (RIP140).
Quantity: 25 μg
Research Discipline: Signaling
Gene ID (Entrez): __
Target Species: Mouse, Rat, Human
Form: Purified
Applications: ChIP Assay, Western Blot
Clone: 6D7
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 6D7 detects Nuclear receptor-interacting protein 1 (RIP140) in human, mouse, and rat cells. It targets an epitope with in 178 amino acids from the N-terminal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Antigen:
RIP140
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
GST-tagged recombinant fragment corresponding to 178 amino acids from the N-terminal half of human Nuclear receptor-interacting protein 1 (RIP140).
Quantity:
25 μg
Research Discipline:
Signaling
Gene ID (Entrez):
__
Target Species:
Mouse, Rat, Human
Form:
Purified
Applications:
ChIP Assay, Western Blot
Clone:
6D7
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 6D7 detects Nuclear receptor-interacting protein 1 (RIP140) in human, mouse, and rat cells. It targets an epitope with in 178 amino acids from the N-terminal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1
Antigen: __
Classification: __
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Applications: __
Clone: __
Conjugate: __
Gene: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Isotype: __
Antigen:
__
Classification:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Form:
__
Applications:
__
Clone:
__
Conjugate:
__
Gene:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__