MAB427CMI
MilliporeSigma™ Cav1.1 alpha1s, Mouse, Unlabeled, Clone: 1A,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MAB427CMI-Each-of-1 | In Stock | ₹ 36,249.21 |
MAB427CMI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 36,249.21
GST (18%): ₹ 6,524.858
Total Price: ₹ 42,774.068
Antigen
Cav1.1 alpha1s
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing PBS without preservatives.
Gene Accession No.
P07293
Immunogen
Dihydropyridine-binding complex isolated from rabbit muscle t-tubules.
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_001095190
Target Species
Human
Form
Purified
Applications
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
1A
Conjugate
Unconjugated
Gene
CACNA1S, CACH1, CACN1, CACNL1A3
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 1A targets the extracellular region of voltage-dependent L-type calcium channel subunit alpha-1S or Cav1.1 encoded by the CACNA1S gene.
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype
IgG1 κ
Related Products
Description
- Insulin receptor substrate 1 (UniProt P35568; also known as IRS-1) is encoded by the IRS1 gene (Gene ID 3667) in human
- The insulin receptor substrates (IRS-1, IRS-2, IRS-3, and IRS-4) are adaptor proteins involved in modulating cell growth, metabolism, survival, and differentiation by transducing receptor signaling to multiple downstream effectors
- IRS family proteins contain a conserved N-terminal pleckstrin homology (PH) domain (a.a
- 12-115 of human IRS-1), a phosphotyrosine-binding (PTB) domain (a.a
- 160-264 of human IRS-1), and multiple tyrosine phosphorylation sites in the C-terminal region, including Tyr612, Tyr896, Tyr941, Tyr1158, and Tyr1220
- The PTB domain meidates the interaction of IRS-1, -2 and -3 with IR juxtamembrane NPXYp motif, facilitating subsequent receptor-mediated IRS tyrosine phosphorylation
- Upon phosphorylation, IRS proteins serve as binding sites for Src homology 2 (SH2) domain-containing proteins, such as SHP-2 and PI 3-kinase
- Functions of IRS proteins are largely dependent on the phosphorylations of specific tyrosine residues, which in turn are subject to negative regulation by phosphatase activity
- In addition, IRS proteins can be phosphorylated by serine/threonine kinases, such as PI-3 kinase, Akt/PKB, GSK-3, mTOR, and PKC, and increased Ser/Thr phosphorylation reduces their binding to IR and tyrosine phosphorylation
- Inhibition of PI 3-kinase enhances insulin-stimulated IRS-1 Tyr612/Tyr941 phosphorylation (p85-binding sites) and increases IRS-1 association with PI 3-kinase p85 subunit.
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Antigen: Cav1.1 alpha1s
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing PBS without preservatives.
Gene Accession No.: P07293
Immunogen: Dihydropyridine-binding complex isolated from rabbit muscle t-tubules.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001095190
Target Species: Human
Form: Purified
Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 1A
Conjugate: Unconjugated
Gene: CACNA1S, CACH1, CACN1, CACNL1A3
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 1A targets the extracellular region of voltage-dependent L-type calcium channel subunit alpha-1S or Cav1.1 encoded by the CACNA1S gene.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG1 κ
Antigen:
Cav1.1 alpha1s
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing PBS without preservatives.
Gene Accession No.:
P07293
Immunogen:
Dihydropyridine-binding complex isolated from rabbit muscle t-tubules.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001095190
Target Species:
Human
Form:
Purified
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
1A
Conjugate:
Unconjugated
Gene:
CACNA1S, CACH1, CACN1, CACNL1A3
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 1A targets the extracellular region of voltage-dependent L-type calcium channel subunit alpha-1S or Cav1.1 encoded by the CACNA1S gene.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG1 κ
Antigen: Dihydropyridine-sensitive Calcium Channel α 1 Subunit
Classification: Monoclonal
Concentration: __
Formulation: Ascites.
Gene Accession No.: NM_000069.2
Immunogen: __
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human, Mouse, Rabbit, Rat
Form: Ascites
Applications: Flow Cytometry, Immunoprecipitation, Western Blot
Clone: mAB 1a
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: __
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: −20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Isotype: IgG1
Antigen:
Dihydropyridine-sensitive Calcium Channel α 1 Subunit
Classification:
Monoclonal
Concentration:
__
Formulation:
Ascites.
Gene Accession No.:
NM_000069.2
Immunogen:
__
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human, Mouse, Rabbit, Rat
Form:
Ascites
Applications:
Flow Cytometry, Immunoprecipitation, Western Blot
Clone:
mAB 1a
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
−20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Isotype:
IgG1
Antigen: Claudin-11
Classification: Monoclonal
Concentration: __
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.
Gene Accession No.: O75508
Immunogen: NS0 mouse myeloma cell line transfected with human Claudin-11, Met1-Val207, Accession # O75508
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): 5010
Target Species: Human
Form: Purified
Applications: Flow Cytometry, CyTOF
Clone: 398205R
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein A or G purified from cell culture supernatant
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution.
Isotype: IgG2b
Antigen:
Claudin-11
Classification:
Monoclonal
Concentration:
__
Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.
Gene Accession No.:
O75508
Immunogen:
NS0 mouse myeloma cell line transfected with human Claudin-11, Met1-Val207, Accession # O75508
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
5010
Target Species:
Human
Form:
Purified
Applications:
Flow Cytometry, CyTOF
Clone:
398205R
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein A or G purified from cell culture supernatant
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution.
Isotype:
IgG2b
Antigen: Claudin-11
Classification: Monoclonal
Concentration: __
Formulation: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.
Gene Accession No.: O75508
Immunogen: NS0 mouse myeloma cell line transfected with human Claudin-11, Met1-Val207, Accession # O75508
Quantity: 25 μg
Research Discipline: __
Gene ID (Entrez): 5010
Target Species: Human
Form: Purified
Applications: Flow Cytometry, CyTOF
Clone: 398205R
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein A or G purified from cell culture supernatant
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution.
Isotype: IgG2b
Antigen:
Claudin-11
Classification:
Monoclonal
Concentration:
__
Formulation:
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 μm filtered solution in PBS.
Gene Accession No.:
O75508
Immunogen:
NS0 mouse myeloma cell line transfected with human Claudin-11, Met1-Val207, Accession # O75508
Quantity:
25 μg
Research Discipline:
__
Gene ID (Entrez):
5010
Target Species:
Human
Form:
Purified
Applications:
Flow Cytometry, CyTOF
Clone:
398205R
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein A or G purified from cell culture supernatant
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -70°C under sterile conditions after reconstitution.
Isotype:
IgG2b