MABS197825
Osteocalcin (Glu17), Mouse anti-Human, Clone: 5C5, Millipore Sigma™
Manufacturer: MilliporeSigma
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS197825-Each-of-1 | In Stock | ₹ 16,456.61 |
MABS197825 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
Osteocalcin (Glu17)
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
BGLAP
Immunogen
A full length recombinant fragment corresponding to 49 amino acids of the mature decarboxylated osteocalcin (with signal peptide and pro regions cleaved off).
Quantity
25 μg
Research Discipline
Signaling
Test Specificity
Clone 5C5 detects human osteocalcin only when not carboxylated on the first glutamic acid residue (GLU17). It does not react with fully carboxylated osteocalcin.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1
Applications
Dot Blot, ELISA
Clone
5C5
Dilution
Dot Blot Analysis: A representative lot detected Osteocalcin (Glu17) in 3xGlu, Glu17, and 3XGla peptides for human OCN (Courtesy of Mathieu Ferron, Ph.D., Montreal Clinical Research Institute, Montreal, Canada).Enzyme Immunoassay Analysis: A representative lot detected Osteocalcin (Glu17) in human serum.
Gene Alias
Bone Gla protein;BGP;Gamma-carboxyglutamic acid-containing protein
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Description
- Anti-Osteocalcin (Glu17), clone 5C5, Cat
- No
- MABS1978, is a mouse monoclonal antibody that detects decarboxylated osteocalcin and has been tested for use in Dot Blot and Enzyme Immunoassay (ELISA)
- Osteocalcin (UniProt: P02818; also known as Bone Gla protein, BGP, Gamma-carboxyglutamic acid-containing protein) is encoded by the BGLAP gene (Gene ID: 632) in human
- Osteocalcin is a member of the osteocalcin/matrix Gla protein family and can constitute 1 to 2% of the total bone protein
- It is synthesized by osteoblasts and is a major component of the noncollagenous bone matrix
- Osteocalcin is synthesized with a signal peptide (aa 1-23), a propetide (aa 24-51) that are cleaved to generate active secreted form of osteocalcin (aa 52-100)
- Osteocalcin displays a high affinity for calcium and binds strongly to apatite
- Sixty to ninety percent of de novo synthesized osteocalcin is incorporated into the bone matrix where it binds to hydroxyapatite during matrix mineralization
- The remainder of the osteocalcin is released into the circulation where it can be measured as a sensitive marker of bone formation
- Osteocalcin found in serum is almost exclusively derived from the bone formation with little or no contribution from the resorption process
- A major feature of osteocalcin is the presence of 3 vitamin K-dependent gamma-carboxyglutamic acid (Gla) residues, which are found in the first helical region and interact with the inter-calcium spacing in the HAP lattice
- In humans, the percentage of the circulating osteocalcin that is not gamma-carboxylated is used as a biomarker of vitamin K status
- Osteocalcin expression in osteoblasts is stimulated by insulin and adiponectin and osteocalcin enhances insulin sensitivity and differentiation in muscle
- Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Paget's disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency
- (Ref.: Kanazawa I (2015)
- World J Diabetes
- 6(18): 1345 1354; Gundberg, CM et al
- (2012)
- Adv Nutr 3 (2): 149-157).
Compare Similar Items
Show Difference
Antigen: Osteocalcin (Glu17)
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: BGLAP
Immunogen: A full length recombinant fragment corresponding to 49 amino acids of the mature decarboxylated osteocalcin (with signal peptide and pro regions cleaved off).
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: Clone 5C5 detects human osteocalcin only when not carboxylated on the first glutamic acid residue (GLU17). It does not react with fully carboxylated osteocalcin.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Applications: Dot Blot, ELISA
Clone: 5C5
Dilution: Dot Blot Analysis: A representative lot detected Osteocalcin (Glu17) in 3xGlu, Glu17, and 3XGla peptides for human OCN (Courtesy of Mathieu Ferron, Ph.D., Montreal Clinical Research Institute, Montreal, Canada).Enzyme Immunoassay Analysis: A representative lot detected Osteocalcin (Glu17) in human serum.
Gene Alias: Bone Gla protein;BGP;Gamma-carboxyglutamic acid-containing protein
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
Osteocalcin (Glu17)
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
BGLAP
Immunogen:
A full length recombinant fragment corresponding to 49 amino acids of the mature decarboxylated osteocalcin (with signal peptide and pro regions cleaved off).
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
Clone 5C5 detects human osteocalcin only when not carboxylated on the first glutamic acid residue (GLU17). It does not react with fully carboxylated osteocalcin.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1
Applications:
Dot Blot, ELISA
Clone:
5C5
Dilution:
Dot Blot Analysis: A representative lot detected Osteocalcin (Glu17) in 3xGlu, Glu17, and 3XGla peptides for human OCN (Courtesy of Mathieu Ferron, Ph.D., Montreal Clinical Research Institute, Montreal, Canada).Enzyme Immunoassay Analysis: A representative lot detected Osteocalcin (Glu17) in human serum.
Gene Alias:
Bone Gla protein;BGP;Gamma-carboxyglutamic acid-containing protein
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: SREBP-1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: __
Gene Symbols: Srebf1,Srebp1
Immunogen: His-tagged full length murine recombinant Sterol regulatory element-binding protein 1.
Quantity: 100 μL
Research Discipline: Signaling
Test Specificity: Clone 20B12 recognizes SREBP-1 in multiple human tissues.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG
Applications: Western Blot
Clone: 20B12
Dilution: __
Gene Alias: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: __
Antigen:
SREBP-1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
__
Gene Symbols:
Srebf1,Srebp1
Immunogen:
His-tagged full length murine recombinant Sterol regulatory element-binding protein 1.
Quantity:
100 μL
Research Discipline:
Signaling
Test Specificity:
Clone 20B12 recognizes SREBP-1 in multiple human tissues.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG
Applications:
Western Blot
Clone:
20B12
Dilution:
__
Gene Alias:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
__
Antigen: __
Classification: __
Conjugate: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Test Specificity: __
Content And Storage: __
Isotype: __
Applications: __
Clone: __
Dilution: __
Gene Alias: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Conjugate:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__
Applications:
__
Clone:
__
Dilution:
__
Gene Alias:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Antigen: Osteocalcin
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: BGLAP
Immunogen: A full length recombinant fragment corresponding to 49 amino acids of the mature decarboxylated osteocalcin (with signal peptide and pro regions cleaved off).
Quantity: 25 μL
Research Discipline: Signaling
Test Specificity: Clone 4C5 detects all forms of human osteocalcin.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Applications: Dot Blot
Clone: 4C5
Dilution: Dot Blot Analysis: A representative lot detected 3xGlu, Glu17, and 3XGla peptides for human OCN (Courtesy of Mathieu Ferron, Ph.D., Montreal Clinical Research Institute, Montreal, Canada).
Gene Alias: Bone Gla protein;BGP;Gamma-carboxyglutamic acid-containing protein
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
Osteocalcin
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
BGLAP
Immunogen:
A full length recombinant fragment corresponding to 49 amino acids of the mature decarboxylated osteocalcin (with signal peptide and pro regions cleaved off).
Quantity:
25 μL
Research Discipline:
Signaling
Test Specificity:
Clone 4C5 detects all forms of human osteocalcin.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1
Applications:
Dot Blot
Clone:
4C5
Dilution:
Dot Blot Analysis: A representative lot detected 3xGlu, Glu17, and 3XGla peptides for human OCN (Courtesy of Mathieu Ferron, Ph.D., Montreal Clinical Research Institute, Montreal, Canada).
Gene Alias:
Bone Gla protein;BGP;Gamma-carboxyglutamic acid-containing protein
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified