MABS198925
Osteocalcin, Mouse anti-Human, Clone: 4C5, Millipore Sigma™
Manufacturer: MilliporeSigma
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS198925-Each-of-1 | In Stock | ₹ 16,456.61 |
MABS198925 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 16,456.61
GST (18%): ₹ 2,962.19
Total Price: ₹ 19,418.80
Antigen
Osteocalcin
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols
BGLAP
Immunogen
A full length recombinant fragment corresponding to 49 amino acids of the mature decarboxylated osteocalcin (with signal peptide and pro regions cleaved off).
Quantity
25 μL
Research Discipline
Signaling
Test Specificity
Clone 4C5 detects all forms of human osteocalcin.
Content And Storage
Stable for 1 year at 2-8°C from date of receipt.
Isotype
IgG1
Applications
Dot Blot
Clone
4C5
Dilution
Dot Blot Analysis: A representative lot detected 3xGlu, Glu17, and 3XGla peptides for human OCN (Courtesy of Mathieu Ferron, Ph.D., Montreal Clinical Research Institute, Montreal, Canada).
Gene Alias
Bone Gla protein;BGP;Gamma-carboxyglutamic acid-containing protein
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Description
- Anti-Osteocalcin, clone 4C5, Cat
- No
- MABS1989, is a moue monocloanl antibody that detects osteocalcin and has been tested for use in Dot Blot Osteocalcin (UniProt: P02818; also known as Bone Gla protein, BGP, Gamma-carboxyglutamic acid-containing protein) is encoded by the BGLAP gene (Gene ID: 632) in human
- Osteocalcin is a member of the osteocalcin/matrix Gla protein family and can constitute 1 to 2% of the total bone protein
- It is synthesized by osteoblasts and is a major component of the noncollagenous bone matrix
- Osteocalcin is synthesized with a signal peptide (aa 1-23), a propetide (aa 24-51) that are cleaved to generate active secreted form of osteocalcin (aa 52-100)
- Osteocalcin displays a high affinity for calcium and binds strongly to apatite
- Sixty to ninety percent of de novo synthesized osteocalcin is incorporated into the bone matrix where it binds to hydroxyapatite during matrix mineralization
- The remainder of the osteocalcin is released into the circulation where it can be measured as a sensitive marker of bone formation
- Osteocalcin found in serum is almost exclusively derived from the bone formation with little or no contribution from the resorption process
- A major feature of osteocalcin is the presence of 3 vitamin K-dependent gamma-carboxyglutamic acid (Gla) residues, which are found in the first helical region and interact with the inter-calcium spacing in the HAP lattice
- In humans, the percentage of the circulating osteocalcin that is not gamma-carboxylated is used as a biomarker of vitamin K status
- Osteocalcin expression in osteoblasts is stimulated by insulin and adiponectin and osteocalcin enhances insulin sensitivity and differentiation in muscle
- Serum osteocalcin is elevated in diseases characterized by increased bone turnover such as osteoporosis, hyperparathyroidism and Paget's disease, and low in conditions associated with low bone turnover such as hypoparathyroidism and growth hormone deficiency
- (Ref.: Kanazawa I (2015)
- World J Diabetes
- 6(18): 1345 1354; Gundberg, CM et al
- (2012)
- Adv Nutr 3 (2): 149-157).
Compare Similar Items
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Antigen: Osteocalcin
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: BGLAP
Immunogen: A full length recombinant fragment corresponding to 49 amino acids of the mature decarboxylated osteocalcin (with signal peptide and pro regions cleaved off).
Quantity: 25 μL
Research Discipline: Signaling
Test Specificity: Clone 4C5 detects all forms of human osteocalcin.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Applications: Dot Blot
Clone: 4C5
Dilution: Dot Blot Analysis: A representative lot detected 3xGlu, Glu17, and 3XGla peptides for human OCN (Courtesy of Mathieu Ferron, Ph.D., Montreal Clinical Research Institute, Montreal, Canada).
Gene Alias: Bone Gla protein;BGP;Gamma-carboxyglutamic acid-containing protein
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
Osteocalcin
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
BGLAP
Immunogen:
A full length recombinant fragment corresponding to 49 amino acids of the mature decarboxylated osteocalcin (with signal peptide and pro regions cleaved off).
Quantity:
25 μL
Research Discipline:
Signaling
Test Specificity:
Clone 4C5 detects all forms of human osteocalcin.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1
Applications:
Dot Blot
Clone:
4C5
Dilution:
Dot Blot Analysis: A representative lot detected 3xGlu, Glu17, and 3XGla peptides for human OCN (Courtesy of Mathieu Ferron, Ph.D., Montreal Clinical Research Institute, Montreal, Canada).
Gene Alias:
Bone Gla protein;BGP;Gamma-carboxyglutamic acid-containing protein
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: RhoB
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: RHOB;ARH6;ARHB
Immunogen: KLH-conjugated linear peptide corresponding to 19 amino acids from the C-terminal half of human RhoB.
Quantity: 25 μL
Research Discipline: Signaling
Test Specificity: Clone 7F7 detects RhoB in multiple species. It targets an epitope within 19 amino acids from the C-terminal half. This clone specifically detects RhoB, but not RhoA, Rac1, or cdc42.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Applications: ELISA, Western Blot
Clone: 7F7
Dilution: Western Blotting Analysis: A 1:2,000 dilution from a representative lotdetected RhoB in 10μg of MCF7 cell lysate. Western Blotting Analysis: A representative lot detected RhoB in mouse and rabbit spleen, mouse kidney, recombinant RhoB, 293 cells expressing RhoB, CHO, H9C2, PK1P.185, COS, MDA MB-231, MCF7 and chicken fibroblasts (Courtesy of Lisa Laury-Kleintop, Ph.D. , Lankenau Institute for Medical Research, Philadelphia PA, USA). ELISA Analysis: A representative lot detected RhoB in Plate bound recombinant RhoB (Courtesy of Lisa Laury-Kleintop, Ph.D. , Lankenau Institute for Medical Research, Philadelphia PA, USA).
Gene Alias: Rho-related GTP-binding protein RhoB;Rho cDNA clone 6;h6
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Monkey, Porcine, Rat, Chicken, Human, Mouse, Rabbit, Hamster
Form: Purified
Antigen:
RhoB
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
RHOB;ARH6;ARHB
Immunogen:
KLH-conjugated linear peptide corresponding to 19 amino acids from the C-terminal half of human RhoB.
Quantity:
25 μL
Research Discipline:
Signaling
Test Specificity:
Clone 7F7 detects RhoB in multiple species. It targets an epitope within 19 amino acids from the C-terminal half. This clone specifically detects RhoB, but not RhoA, Rac1, or cdc42.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1
Applications:
ELISA, Western Blot
Clone:
7F7
Dilution:
Western Blotting Analysis: A 1:2,000 dilution from a representative lotdetected RhoB in 10μg of MCF7 cell lysate. Western Blotting Analysis: A representative lot detected RhoB in mouse and rabbit spleen, mouse kidney, recombinant RhoB, 293 cells expressing RhoB, CHO, H9C2, PK1P.185, COS, MDA MB-231, MCF7 and chicken fibroblasts (Courtesy of Lisa Laury-Kleintop, Ph.D. , Lankenau Institute for Medical Research, Philadelphia PA, USA). ELISA Analysis: A representative lot detected RhoB in Plate bound recombinant RhoB (Courtesy of Lisa Laury-Kleintop, Ph.D. , Lankenau Institute for Medical Research, Philadelphia PA, USA).
Gene Alias:
Rho-related GTP-binding protein RhoB;Rho cDNA clone 6;h6
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Monkey, Porcine, Rat, Chicken, Human, Mouse, Rabbit, Hamster
Form:
Purified
Antigen: MT-ND4
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG2a in buffer containing HEPES-Buffered Saline (150 mM NaCl, 15 mM HEPES, pH 7.2) with 0.02% sodium azide.
Gene Symbols: MT-ND4;MTND4;NADH4;ND4
Immunogen: KLH-conjugated linear peptide from the C-terminal region.
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: Clone 9E4-2D8 detects NADH-ubiquinone oxidoreductase chain 4 in mitochodria isolated from human cells.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2a
Applications: Western Blot
Clone: 9E4-2D8
Dilution: Western Blotting Analysis: 4μg/mL from a representative lot detected MT-ND4 in mitochondria from Human Neonatal Dermal Fibroblasts and mitochondria from Human neonatal dermal fibroblasts depleted of mtDNA. (Courtesy of Michael F. Marusich, Ph.D., mAbDx, Inc., Eugene, OR, USA ).
Gene Alias: NADH-ubiquinone oxidoreductase chain 4;EC: 1.6.5.3;NADH dehydrogenase subunit 4
Host Species: Mouse
Purification Method: Protein L
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
MT-ND4
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG2a in buffer containing HEPES-Buffered Saline (150 mM NaCl, 15 mM HEPES, pH 7.2) with 0.02% sodium azide.
Gene Symbols:
MT-ND4;MTND4;NADH4;ND4
Immunogen:
KLH-conjugated linear peptide from the C-terminal region.
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
Clone 9E4-2D8 detects NADH-ubiquinone oxidoreductase chain 4 in mitochodria isolated from human cells.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2a
Applications:
Western Blot
Clone:
9E4-2D8
Dilution:
Western Blotting Analysis: 4μg/mL from a representative lot detected MT-ND4 in mitochondria from Human Neonatal Dermal Fibroblasts and mitochondria from Human neonatal dermal fibroblasts depleted of mtDNA. (Courtesy of Michael F. Marusich, Ph.D., mAbDx, Inc., Eugene, OR, USA ).
Gene Alias:
NADH-ubiquinone oxidoreductase chain 4;EC: 1.6.5.3;NADH dehydrogenase subunit 4
Host Species:
Mouse
Purification Method:
Protein L
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: MT-ATP6
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: Purified mouse monoclonal antibody IgG2b in HEPES-Buffered Saline (15 mM HEPES, 150 mM NaCl, pH 7.2) with 0.02% sodium azide.
Gene Symbols: MT-ATP6;ATP6;ATPASE6;MTATP6
Immunogen: A synthetic peptide corresponding to the N-terminus of human MT-ATP6.
Quantity: 25 μg
Research Discipline: Signaling
Test Specificity: Clone 1G7-1G2 detects ATP synthase subunit a (MT-ATP6) in mitochondria isolated from human cells.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG2b κ
Applications: Western Blot
Clone: 1G7-1G2
Dilution: Western Blotting Analysis: 0.5μg/mL from a representative lot detected MT-ATP6 in mitochondria from human neonatal dermal fibroblasts and mitochondria from human neonatal dermal fibroblasts depleted of mtDNA (Courtesy of Michael F. Marusich, Ph.D., mAbDx, Inc., Eugene, OR USA).
Gene Alias: ATP synthase subunit a;F-ATPase protein 6
Host Species: Mouse
Purification Method: Protein L
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
MT-ATP6
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
Purified mouse monoclonal antibody IgG2b in HEPES-Buffered Saline (15 mM HEPES, 150 mM NaCl, pH 7.2) with 0.02% sodium azide.
Gene Symbols:
MT-ATP6;ATP6;ATPASE6;MTATP6
Immunogen:
A synthetic peptide corresponding to the N-terminus of human MT-ATP6.
Quantity:
25 μg
Research Discipline:
Signaling
Test Specificity:
Clone 1G7-1G2 detects ATP synthase subunit a (MT-ATP6) in mitochondria isolated from human cells.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG2b κ
Applications:
Western Blot
Clone:
1G7-1G2
Dilution:
Western Blotting Analysis: 0.5μg/mL from a representative lot detected MT-ATP6 in mitochondria from human neonatal dermal fibroblasts and mitochondria from human neonatal dermal fibroblasts depleted of mtDNA (Courtesy of Michael F. Marusich, Ph.D., mAbDx, Inc., Eugene, OR USA).
Gene Alias:
ATP synthase subunit a;F-ATPase protein 6
Host Species:
Mouse
Purification Method:
Protein L
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified