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MABT82125UL

Integrin beta1 (CD29), Rat anti-Human, Clone: mAb13, Millipore Sigma™

Manufacturer: MilliporeSigma

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Pack Size	SKU	Availability	Price
Each of 1	MABT82125UL-Each-of-1	In Stock	₹ 16,456.61

MABT82125UL - Each of 1

₹ 16,456.61

In Stock

Quantity

Base Price: ₹ 16,456.61

GST (18%): ₹ 2,962.19

Total Price: ₹ 19,418.80

Antigen

Integrin beta1 (CD29)

Classification

Monoclonal

Conjugate

Unconjugated

Formulation

Purified rat monoclonal antibody IgG2a in PBS without preservatives.

Gene Symbols

ITGB1;FNRB;MDF2;MSK12

Immunogen

Fibronectin receptor (alpha V beta 1) purified from human placenta.

Quantity

25 μL

Research Discipline

Cell Structure

Test Specificity

Clone mAb13 specifically detects beta 1 subunit of human integrin. It targets an epitope within 12 amino acids from the N-terminal region.

Content And Storage

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Isotype

IgG2a κ

Applications

Immunocytochemistry, Immunoprecipitation, Inhibition Assays

Clone

mAb13

Dilution

Inhibition Analysis: A representative lot blocked cell attachment in Inhibition studies (Akiyama, S.K., et. al. (1989). J Cell Biol. 109(2):863-75; Humphries, J.D., et. al. (2005). J Biol Chem. 280(11):10234-43). Immunocytochemistry Analysis: A representative lot detected Integrin beta1 (CD29) in Immunocytochemistry applications (Akiyama, S.K., et. al. (1989). J Cell Biol. 109(2):863-75; Humphries, J.D., et. al. (2005). J Biol Chem. 280(11):10234-43). Immunoprecipitation Analysis: A representative lot detected Integrin beta1 (CD29) in Immunoprecipitation applications (Akiyama, S.K., et. al. (1989). J Cell Biol. 109(2):863-75). Inhibition Analysis: A representative lot blocked HT-1080 cells adhesion to fibronectin coated plates (Courtesy of Dr. Kenneth M. Yamada, M.D., Ph.D., NIDCR, National Institutes of Health, Bethesda, MD USA).

Gene Alias

Fibronectin receptor subunit beta;Glycoprotein IIa;GPIIA;VLA-4 subunit beta;CD29

Host Species

Rat

Purification Method

Protein G purified

Regulatory Status

RUO

Primary or Secondary

Primary

Target Species

Human

Form

Purified

Description

Anti-Integrin beta1 (CD29), clone mAb13, Cat
No
MABT821, is a rat monoclonal antibody that detects integrin beta-1 and has been tested for use in Immunocytochemistry, Immunoprecipitation, and Inhibition studies
Integrin beta-1 (UniProt: P05556; also known as Fibronectin receptor subunit beta, Glycoprotein IIa, GPIIA, VLA-4 subunit beta, CD29) is encoded by the ITGB1 (also known as FNRB, MDF2, MSK12) gene (Gene ID: 3688) in human
Integrin beta-1 is a single-pass type I membrane protein that associates with one of the alpha subunits to form receptor for fibronectin
Integrin beta-1 integrin recognizes the sequence R-G-D in a wide array of ligands
Five isoforms of integrin beta-1 have been reported that are produced by alternative splicing
Integrin beta-1 is synthesized with a signal peptide (aa 1-20) that is subsequently cleaved off
The mature form has an extracellular domain (aa 21-728), a helical domain (aa 729-751) and a cytoplasmic region (aa 752-798)
Isoform 1 of integrin beta-1 is widely expressed and other isoforms are generally co-expressed with a more restricted distribution
Isoform 2 is expressed in skin, liver, skeletal muscle, cardiac muscle, placenta, umbilical vein endothelial cells, neuroblastoma cells, lymphoma cells, hepatoma cells and astrocytoma cells
Isoform 3 and isoform 4 are expressed in muscle, kidney, liver, placenta, cervical epithelium, umbilical vein endothelial cells, fibroblast cells, embryonal kidney cells, platelets and several blood cell lines
Isoform 4 is selectively expressed in peripheral T-cells and isoform 5 is expressed specifically in striated muscle (skeletal and cardiac muscle)
Isoform 2 is reported to interfere with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro).

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MilliporeSigma

MABT82125UL

Antigen:

Integrin beta1 (CD29)

Classification:

Monoclonal

Conjugate:

Unconjugated

Formulation:

Purified rat monoclonal antibody IgG2a in PBS without preservatives.

Gene Symbols:

ITGB1;FNRB;MDF2;MSK12

Immunogen:

Fibronectin receptor (alpha V beta 1) purified from human placenta.

Quantity:

25 μL

Research Discipline:

Cell Structure

Test Specificity:

Clone mAb13 specifically detects beta 1 subunit of human integrin. It targets an epitope within 12 amino acids from the N-terminal region.

Content And Storage:

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Isotype:

IgG2a κ

Applications:

Immunocytochemistry, Immunoprecipitation, Inhibition Assays

Clone:

mAb13

Dilution:

Inhibition Analysis: A representative lot blocked cell attachment in Inhibition studies (Akiyama, S.K., et. al. (1989). J Cell Biol. 109(2):863-75; Humphries, J.D., et. al. (2005). J Biol Chem. 280(11):10234-43). Immunocytochemistry Analysis: A representative lot detected Integrin beta1 (CD29) in Immunocytochemistry applications (Akiyama, S.K., et. al. (1989). J Cell Biol. 109(2):863-75; Humphries, J.D., et. al. (2005). J Biol Chem. 280(11):10234-43). Immunoprecipitation Analysis: A representative lot detected Integrin beta1 (CD29) in Immunoprecipitation applications (Akiyama, S.K., et. al. (1989). J Cell Biol. 109(2):863-75). Inhibition Analysis: A representative lot blocked HT-1080 cells adhesion to fibronectin coated plates (Courtesy of Dr. Kenneth M. Yamada, M.D., Ph.D., NIDCR, National Institutes of Health, Bethesda, MD USA).

Gene Alias:

Fibronectin receptor subunit beta;Glycoprotein IIa;GPIIA;VLA-4 subunit beta;CD29

Host Species:

Rat

Purification Method:

Protein G purified

Regulatory Status:

RUO

Primary or Secondary:

Primary

Target Species:

Human

Form:

Purified

Sigma Aldrich

MABT823

clone 22D3, from mouse...

Antigen:

Classification:

Conjugate:

Formulation:

Gene Symbols:

Immunogen:

Quantity:

Research Discipline:

Test Specificity:

Content And Storage:

Isotype:

Applications:

Clone:

Dilution:

Gene Alias:

Host Species:

Purification Method:

Regulatory Status:

Primary or Secondary:

Target Species:

Form:

__

MilliporeSigma™

MABT823MI

Antigen:

alpha-Actin, Cardiac Muscle

Classification:

Monoclonal

Conjugate:

Unconjugated

Formulation:

Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Symbols:

Immunogen:

KLH-conjugated linear peptide corresponding to human mature alpha-cardiac actin N-terminal end sequence with an acetylated N-terminus.

Quantity:

100 μL

Research Discipline:

Cell Structure

Test Specificity:

Clone 22D3 specifically detected alpha-cardiac actin in rat myocardium homogenates with no cross-reactivity toward - or -smooth muscle actin in rat aorta and chicken gizzard homogenates, cytoplasmic - or -actin in human platelet lysate, nor -skeletal actin in rat skeletal muscle homogenate (Driesen, R.B., et al. (2009). J. Cell. Mol. Med. 13(5):896-908).

Content And Storage:

Stable for 1 year at 2°-8°C from date of receipt.

Isotype:

IgG1 κ

Applications:

Immunocytochemistry, Immunofluorescence, Western Blot

Clone:

22D3

Dilution:

Gene Alias:

__

Host Species:

Mouse

Purification Method:

Protein G Purified

Regulatory Status:

RUO

Primary or Secondary:

Primary

Target Species:

Goat

Form:

Purified

MilliporeSigma™

MABT825

Antigen:

beta-Actin

Classification:

Monoclonal

Conjugate:

Formulation:

Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Symbols:

ACTB

Immunogen:

KLH-conjugated linear peptide corresponding to the the N-terminal sequence of human beta-Actin.

Quantity:

100 μg

Research Discipline:

Cell Structure

Test Specificity:

Content And Storage:

Stable for one year at 2°C to 8°C from date of receipt.

Isotype:

IgG1 κ

Applications:

Immunocytochemistry, Western Blot

Clone:

4C2

Dilution:

Gene Alias:

Host Species:

Mouse

Purification Method:

Protein G Purified

Regulatory Status:

RUO

Primary or Secondary:

Primary

Target Species:

Chicken, Human, Mouse, Rat

Form:

Purified

Integrin beta1 (CD29), Rat anti-Human, Clone: mAb13, Millipore Sigma™

Select a Size

Select a Size

Properties

Antigen

Classification

Conjugate

Formulation

Gene Symbols

Immunogen

Quantity

Research Discipline

Test Specificity

Content And Storage

Isotype

Applications

Clone

Dilution

Gene Alias

Host Species

Purification Method

Regulatory Status

Primary or Secondary

Target Species

Form

Description

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MilliporeSigma

Sigma Aldrich

MilliporeSigma™

MilliporeSigma™