MS107B1
Epredia™ Lab Vision™ Retinoblastoma (Rb) Ab-1 Mouse Monoclonal Antibody, 200μg/mL, biotinylated, BSA and azide
Manufacturer: Fischer Scientific
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Antigen
Retinoblastoma (Rb) Ab-1
Classification
Monoclonal
Concentration
200μg/mL
Host Species
Mouse
Quantity
500 μL
Research Discipline
Cancer and Tumor Biology
Target Species
Human
Isotype
IgG1
Applications
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
1F8; same as Rb1
Conjugate
Biotin
Immunogen
Recombinant human Rb protein
Regulatory Status
RUO
Primary or Secondary
Primary
Form
Concentrated
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Description
- Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA
- It is phosphorylated on serine and threonine, but not on tyrosine residues
- It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus-16 E
- Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth
- Aberrations in the RB gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia
- Host Species: Mouse Clone: 1F8; same as Rb1 Isotype: IgG1 Species Reactivity: Human
- Does not react with mouse and rat
- Others not known
- Epitope: aa 703-722 Immunogen: Recombinant human Rb protein Molecular Weight: 105kDa Positive Control: Ls174T, HT29, HUVEC cells; Normal colon, Breast CA and colon CA Cellular Localization: Nuclear Ab-1 specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells
- It reacts with hyperphosphorylated and un (under) phosphorylated form of Rb protein
- It shows no cross reaction with p107 and p130
- Recommended for: Immunohistochemistry (Formalin/paraffin) Western Blotting Immunofluorescence Immunoprecipitation (Native and denatured) Flow Cytometry Note: USA: RUO; Int'l: RUO
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Antigen: Retinoblastoma (Rb) Ab-1
Classification: Monoclonal
Concentration: 200μg/mL
Host Species: Mouse
Quantity: 500 μL
Research Discipline: Cancer and Tumor Biology
Target Species: Human
Isotype: IgG1
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 1F8; same as Rb1
Conjugate: Biotin
Immunogen: Recombinant human Rb protein
Regulatory Status: RUO
Primary or Secondary: Primary
Form: Concentrated
Antigen:
Retinoblastoma (Rb) Ab-1
Classification:
Monoclonal
Concentration:
200μg/mL
Host Species:
Mouse
Quantity:
500 μL
Research Discipline:
Cancer and Tumor Biology
Target Species:
Human
Isotype:
IgG1
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
1F8; same as Rb1
Conjugate:
Biotin
Immunogen:
Recombinant human Rb protein
Regulatory Status:
RUO
Primary or Secondary:
Primary
Form:
Concentrated
Antigen: Retinoblastoma (Rb) Ab-1
Classification: Monoclonal
Concentration: 200μg/mL
Host Species: Mouse
Quantity: 100 μL
Research Discipline: Cancer and Tumor Biology
Target Species: Human
Isotype: IgG1
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 1F8; same as Rb1
Conjugate: Unconjugated
Immunogen: Recombinant human Rb protein
Regulatory Status: RUO
Primary or Secondary: Primary
Form: Concentrated
Antigen:
Retinoblastoma (Rb) Ab-1
Classification:
Monoclonal
Concentration:
200μg/mL
Host Species:
Mouse
Quantity:
100 μL
Research Discipline:
Cancer and Tumor Biology
Target Species:
Human
Isotype:
IgG1
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
1F8; same as Rb1
Conjugate:
Unconjugated
Immunogen:
Recombinant human Rb protein
Regulatory Status:
RUO
Primary or Secondary:
Primary
Form:
Concentrated
Antigen: Retinoblastoma (Rb) Ab-1
Classification: Monoclonal
Concentration: 200μg/mL
Host Species: Mouse
Quantity: 500 μL
Research Discipline: Cancer and Tumor Biology
Target Species: Human
Isotype: IgG1
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 1F8; same as Rb1
Conjugate: Unconjugated
Immunogen: Recombinant human Rb protein
Regulatory Status: RUO
Primary or Secondary: Primary
Form: Concentrated
Antigen:
Retinoblastoma (Rb) Ab-1
Classification:
Monoclonal
Concentration:
200μg/mL
Host Species:
Mouse
Quantity:
500 μL
Research Discipline:
Cancer and Tumor Biology
Target Species:
Human
Isotype:
IgG1
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
1F8; same as Rb1
Conjugate:
Unconjugated
Immunogen:
Recombinant human Rb protein
Regulatory Status:
RUO
Primary or Secondary:
Primary
Form:
Concentrated
Antigen: Retinoblastoma (Rb) Ab-1
Classification: Monoclonal
Concentration: 1mg/mL
Host Species: Mouse
Quantity: 100 μL
Research Discipline: Cancer and Tumor Biology
Target Species: Human
Isotype: IgG1
Applications: Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 1F8; same as Rb1
Conjugate: Unconjugated
Immunogen: Recombinant human Rb protein
Regulatory Status: RUO
Primary or Secondary: Primary
Form: Concentrated
Antigen:
Retinoblastoma (Rb) Ab-1
Classification:
Monoclonal
Concentration:
1mg/mL
Host Species:
Mouse
Quantity:
100 μL
Research Discipline:
Cancer and Tumor Biology
Target Species:
Human
Isotype:
IgG1
Applications:
Flow Cytometry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
1F8; same as Rb1
Conjugate:
Unconjugated
Immunogen:
Recombinant human Rb protein
Regulatory Status:
RUO
Primary or Secondary:
Primary
Form:
Concentrated