Epredia™ Lab Vision™ NY-BR-1 Mouse Monoclonal Antibody

Description

• NY-BR-1 is a novel differentiation marker predominantly expressed in normal breast and breast cancer
• It has been shown by Immunohistochemistry (IHC) that NY-BR-1 was present solely in ductal epithelium of normal breast tissue
• Invasive carcinoma of the breast and carcinoma in situ were positive for NY-BR-1, whereas most other tumors and normal tissues are negative, with the exceptions of one-third of sweat gland carcinomas and around two percent of prostate carcinoma
• NY-BR-1 is reported to express more frequently in estrogen-positive and lymph node-negative primary carcinomas, and more commonly in grade 1 than in grade 2 or grade 3
• In a study by Varga et al (2006) forty-nine percent of lymph node metastasis were shown to be positive
• Host Species: Mouse Clone: NY-BR-1No
• 2 Isotype: IgG1/κ Species Reactivity: Human
• Others not tested
• Epitope: Not determined Immunogen: a 77 aa peptide from human NYBR-1 protein Molecular Weight: 150-160kDa Positive Control: Breast carcinoma Cellular Localization: Predominantly cytoplasmic and occasional nuclear Recommended for: Immunohistochemistry (Formalin/paraffin)