NBP248074
Transgelin/TAGLN/SM22 alpha Antibody (SPM606) - IHC-Prediluted, Novus Biologicals™
Manufacturer: Novus Biologicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP248074-Each-of-1 | In Stock | ₹ 44,833.44 |
NBP248074 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,833.44
GST (18%): ₹ 8,070.019
Total Price: ₹ 52,903.459
Antigen
Transgelin/TAGLN/SM22 alpha
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols
TAGLN
Immunogen
Recombinant full-length human Transgelin/TAGLN/SM22 alpha protein. (Uniprot: Q01995)
Purification Method
Protein A or G purified
Regulatory Status
RUO
Gene ID (Entrez)
6876
Target Species
Human, Mouse, Porcine, Primate, Rabbit
Form
Purified
Applications
Immunohistochemistry (Paraffin)
Clone
SPM606
Dilution
Immunohistochemistry-Paraffin
Gene Alias
DKFZp686P11128, Protein WS3-10, SM2222 kDa actin-binding protein, SMCCDKFZp686B01212, Smooth muscle protein 22-alpha, TAGLN1, transgelin, transgelin variant 2, WS3-10SM22-alpha
Host Species
Mouse
Molecular Weight of Antigen
22 kDa
Quantity
7 mL
Primary or Secondary
Primary
Test Specificity
This monoclonal antibody recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
Content And Storage
Store at 4C.
Isotype
IgG1 κ
Related Products
Description
- Transgelin/TAGLN/SM22 alpha Monoclonal specifically detects Transgelin/TAGLN/SM22 alpha in Human, Mouse, Porcine, Bovine, Rabbit samples
- It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
Compare Similar Items
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Antigen: Transgelin/TAGLN/SM22 alpha
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: TAGLN
Immunogen: Recombinant full-length human Transgelin/TAGLN/SM22 alpha protein. (Uniprot: Q01995)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Gene ID (Entrez): 6876
Target Species: Human, Mouse, Porcine, Primate, Rabbit
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: SPM606
Dilution: Immunohistochemistry-Paraffin
Gene Alias: DKFZp686P11128, Protein WS3-10, SM2222 kDa actin-binding protein, SMCCDKFZp686B01212, Smooth muscle protein 22-alpha, TAGLN1, transgelin, transgelin variant 2, WS3-10SM22-alpha
Host Species: Mouse
Molecular Weight of Antigen: 22 kDa
Quantity: 7 mL
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Antigen:
Transgelin/TAGLN/SM22 alpha
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
TAGLN
Immunogen:
Recombinant full-length human Transgelin/TAGLN/SM22 alpha protein. (Uniprot: Q01995)
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Gene ID (Entrez):
6876
Target Species:
Human, Mouse, Porcine, Primate, Rabbit
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
SPM606
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
DKFZp686P11128, Protein WS3-10, SM2222 kDa actin-binding protein, SMCCDKFZp686B01212, Smooth muscle protein 22-alpha, TAGLN1, transgelin, transgelin variant 2, WS3-10SM22-alpha
Host Species:
Mouse
Molecular Weight of Antigen:
22 kDa
Quantity:
7 mL
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ
Antigen: Cytokeratin 18
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: KRT18
Immunogen: Cytoskeletal preparation extracted from the human vulvar squamous carcinoma cell line A431.
Purification Method: Protein A or G purified
Regulatory Status: RUO
Gene ID (Entrez): 3875
Target Species: Human, Mouse, Rat, Porcine, Canine, Equine, Feline, Goat, Hamster, Ferret, Monkey, Primate, Sheep, Chicken (Negative), Xenopus (Negative)
Form: Purified
Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
Clone: C-04 (same as Ks18.04)
Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
Gene Alias: Cell proliferation-inducing gene 46 protein, cell proliferation-inducing protein 46, CK-18, CYK18, cytokeratin 18, cytokeratin-18, K18, keratin 18, keratin, type I cytoskeletal 18, keratin-18
Host Species: Mouse
Molecular Weight of Antigen: 45 kDa
Quantity: 7 mL
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Antigen:
Cytokeratin 18
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
KRT18
Immunogen:
Cytoskeletal preparation extracted from the human vulvar squamous carcinoma cell line A431.
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Gene ID (Entrez):
3875
Target Species:
Human, Mouse, Rat, Porcine, Canine, Equine, Feline, Goat, Hamster, Ferret, Monkey, Primate, Sheep, Chicken (Negative), Xenopus (Negative)
Form:
Purified
Applications:
Immunohistochemistry, Immunohistochemistry (Paraffin)
Clone:
C-04 (same as Ks18.04)
Dilution:
Immunohistochemistry, Immunohistochemistry-Paraffin
Gene Alias:
Cell proliferation-inducing gene 46 protein, cell proliferation-inducing protein 46, CK-18, CYK18, cytokeratin 18, cytokeratin-18, K18, keratin 18, keratin, type I cytoskeletal 18, keratin-18
Host Species:
Mouse
Molecular Weight of Antigen:
45 kDa
Quantity:
7 mL
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It was reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ
Antigen: Cytokeratin 18
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: KRT18
Immunogen: Recombinant full-length human Cytokeratin 18 protein (Uniprot: P05783)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Gene ID (Entrez): 3875
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: Cocktail
Dilution: Immunohistochemistry-Paraffin
Gene Alias: Cell proliferation-inducing gene 46 protein, cell proliferation-inducing protein 46, CK-18, CYK18, cytokeratin 18, cytokeratin-18, K18, keratin 18, keratin, type I cytoskeletal 18, keratin-18
Host Species: Mouse
Molecular Weight of Antigen: 45 kDa
Quantity: 7 mL
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It is reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Antigen:
Cytokeratin 18
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
KRT18
Immunogen:
Recombinant full-length human Cytokeratin 18 protein (Uniprot: P05783)
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Gene ID (Entrez):
3875
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
Cocktail
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
Cell proliferation-inducing gene 46 protein, cell proliferation-inducing protein 46, CK-18, CYK18, cytokeratin 18, cytokeratin-18, K18, keratin 18, keratin, type I cytoskeletal 18, keratin-18
Host Species:
Mouse
Molecular Weight of Antigen:
45 kDa
Quantity:
7 mL
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody reacts with a wide variety of simple epithelia. It does not react with stratified squamous epithelia. It reacts with epithelial tumors of the gastrointestinal tract, lung, breast, pancreas, ovary, and thyroid. Cytokeratin 18, which belongs to the type A (acidic) subfamily of low molecular weight keratins, exists in combination with cytokeratin 8. It is reported that tissues from gastrointestinal tract are positive for both cytokeratin 8 and 18 but do not contain cytokeratin 14. Tissues from gastrointestinal tract, respiratory tract and urogenital tract, as well as endocrine and exocrine tissues and mesothelial cells are positive for cytokeratin 18.
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ
Antigen: H1F0
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: H1-0
Immunogen: Nuclei of human leukemia biopsy cells
Purification Method: Protein A or G purified
Regulatory Status: RUO
Gene ID (Entrez): 3005
Target Species: Human, Mouse, Rat
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: 1415-1
Dilution: Immunohistochemistry-Paraffin
Gene Alias: H1 histone family, member 0, H1.0, H1(0), H1-0, H10, H1FVMGC5241, Histone H1', Histone H1(0), histone H1.0
Host Species: Mouse
Molecular Weight of Antigen: __
Quantity: 7 mL
Primary or Secondary: Primary
Test Specificity: Eukaryotic histones are basic and water-soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.
Content And Storage: Store at 4C.
Isotype: IgG2a κ
Antigen:
H1F0
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
1.0mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
H1-0
Immunogen:
Nuclei of human leukemia biopsy cells
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Gene ID (Entrez):
3005
Target Species:
Human, Mouse, Rat
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
1415-1
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
H1 histone family, member 0, H1.0, H1(0), H1-0, H10, H1FVMGC5241, Histone H1', Histone H1(0), histone H1.0
Host Species:
Mouse
Molecular Weight of Antigen:
__
Quantity:
7 mL
Primary or Secondary:
Primary
Test Specificity:
Eukaryotic histones are basic and water-soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.
Content And Storage:
Store at 4C.
Isotype:
IgG2a κ