NBP248118
TTF-1/ NKX2-1 Antibody (8G7G3/1 + NX2.1/690) - IHC-Prediluted, Novus Biologicals™
Manufacturer: Novus Biologicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP248118-Each-of-1 | In Stock | ₹ 44,833.44 |
NBP248118 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,833.44
GST (18%): ₹ 8,070.019
Total Price: ₹ 52,903.459
Antigen
TTF-1 / NKX2-1
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols
NKX2-1
Immunogen
Rat full length TTF-1/ NKX2-1 recombinant protein (8G7G3/1); Recombinant TTF-1/ NKX2-1 protein (NX2.1/690) (Uniprot: P43699)
Purification Method
Protein A or G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
Content And Storage
Store at 4C.
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin)
Clone
8G7G3/1 + NX2.1/690
Dilution
Immunohistochemistry-Paraffin
Gene Alias
benign chorea, Homeobox protein NK-2 homolog A, homeobox protein Nkx-2.1, NK2 homeobox 1, NK-2 homolog A, NKX2ANKX2.1, Thyroid nuclear factor 1, Thyroid transcription factor 1BHC, TITF1TEBP, TTF1, TTF1BCH, TTF-1NK-2
Host Species
Mouse
Molecular Weight of Antigen
40 kDa
Quantity
7 mL
Research Discipline
Membrane Trafficking and Chaperones, Tumor Biomarkers
Gene ID (Entrez)
7080
Target Species
Human, Mouse, Rat
Form
Purified
Related Products
Description
- TTF-1 / NKX2-1 Monoclonal specifically detects TTF-1 / NKX2-1 in Human, Mouse, Rat samples
- It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
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Antigen: TTF-1 / NKX2-1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: NKX2-1
Immunogen: Rat full length TTF-1/ NKX2-1 recombinant protein (8G7G3/1); Recombinant TTF-1/ NKX2-1 protein (NX2.1/690) (Uniprot: P43699)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin)
Clone: 8G7G3/1 + NX2.1/690
Dilution: Immunohistochemistry-Paraffin
Gene Alias: benign chorea, Homeobox protein NK-2 homolog A, homeobox protein Nkx-2.1, NK2 homeobox 1, NK-2 homolog A, NKX2ANKX2.1, Thyroid nuclear factor 1, Thyroid transcription factor 1BHC, TITF1TEBP, TTF1, TTF1BCH, TTF-1NK-2
Host Species: Mouse
Molecular Weight of Antigen: 40 kDa
Quantity: 7 mL
Research Discipline: Membrane Trafficking and Chaperones, Tumor Biomarkers
Gene ID (Entrez): 7080
Target Species: Human, Mouse, Rat
Form: Purified
Antigen:
TTF-1 / NKX2-1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
NKX2-1
Immunogen:
Rat full length TTF-1/ NKX2-1 recombinant protein (8G7G3/1); Recombinant TTF-1/ NKX2-1 protein (NX2.1/690) (Uniprot: P43699)
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Recognizes a protein of 40kDa, identified as Thyroid transcription factor-1 (TTF-1). TTF-1 is a member of the NKx2 family of homeodomain transcription factors. It is expressed in epithelial cells of the thyroid gland and the lung. Nuclei from liver, stomach, pancreas, small intestine, colon, kidney, breast, skin, testes, pituitary, prostate, and adrenal glands are unreactive. Anti-TTF-1 is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the breast, mediastinal germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates.Loss of TTF-1 expression in non-small cell lung carcinoma has been associated with aggressive behavior of such neoplasms. TTF-1 reactivity is also seen in thyroid malignancies.
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ
Applications:
Immunohistochemistry (Paraffin)
Clone:
8G7G3/1 + NX2.1/690
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
benign chorea, Homeobox protein NK-2 homolog A, homeobox protein Nkx-2.1, NK2 homeobox 1, NK-2 homolog A, NKX2ANKX2.1, Thyroid nuclear factor 1, Thyroid transcription factor 1BHC, TITF1TEBP, TTF1, TTF1BCH, TTF-1NK-2
Host Species:
Mouse
Molecular Weight of Antigen:
40 kDa
Quantity:
7 mL
Research Discipline:
Membrane Trafficking and Chaperones, Tumor Biomarkers
Gene ID (Entrez):
7080
Target Species:
Human, Mouse, Rat
Form:
Purified
Antigen: Tyrosinase
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: TYR
Immunogen: Recombinant tyrosinase protein (Uniprot: P14679 )
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This monoclonal antibody shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this monoclonal antibody shows tyrosinase in melanotic as well as amelanotic variants. This monoclonal antibody is a useful marker for melanocytes and melanomas.
Content And Storage: Store at 4C.
Isotype: IgG2a κ
Applications: Immunohistochemistry (Paraffin)
Clone: T311 + OCA1/812
Dilution: Immunohistochemistry-Paraffin
Gene Alias: CMM8, EC 1.14.18.1, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA)
Host Species: Mouse
Molecular Weight of Antigen: 75 kDa
Quantity: 7 mL
Research Discipline: Lipid and Metabolism
Gene ID (Entrez): 7299
Target Species: Human
Form: Purified
Antigen:
Tyrosinase
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
TYR
Immunogen:
Recombinant tyrosinase protein (Uniprot: P14679 )
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Recognizes a cluster of proteins between 70-80kDa, identified as tyrosinase. Occasionally a minor band at 55kDa is also detected. This monoclonal antibody shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this monoclonal antibody shows tyrosinase in melanotic as well as amelanotic variants. This monoclonal antibody is a useful marker for melanocytes and melanomas.
Content And Storage:
Store at 4C.
Isotype:
IgG2a κ
Applications:
Immunohistochemistry (Paraffin)
Clone:
T311 + OCA1/812
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
CMM8, EC 1.14.18.1, LB24-AB, Monophenol monooxygenase, OCA1A, OCAIA, SHEP3, SK29-AB, Tumor rejection antigen AB, tyrosinase, tyrosinase (oculocutaneous albinism IA)
Host Species:
Mouse
Molecular Weight of Antigen:
75 kDa
Quantity:
7 mL
Research Discipline:
Lipid and Metabolism
Gene ID (Entrez):
7299
Target Species:
Human
Form:
Purified
Antigen: alpha-Fetoprotein/AFP
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: AFP
Immunogen: Alpha feto protein (AFP) Purified from serum of a hepatoma patient (Uniprot: P02771)
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: It recognizes an oncofetal glycoprotein with a single chain of 70kDa, which is identified as alpha fetoprotein (AFP) (ISOBM TD-2 workshop). This monoclonal antibody is highly specific to AFP and shows no cross-reaction with other oncofetal antigens or serum albumin. AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin)
Clone: C2
Dilution: Immunohistochemistry-Paraffin
Gene Alias: Alpha-1-fetoprotein, Alpha-fetoglobulin, alpha-fetoprotein, FETA, HP, HPAFP
Host Species: Mouse
Molecular Weight of Antigen: 70 kDa
Quantity: 7 mL
Research Discipline: Cancer, Cancer Stem Cells, GPCR, Stem Cell Markers, Tumor Biomarkers
Gene ID (Entrez): 174
Target Species: Human, Mouse, Bovine (Negative), Canine (Negative), Rat (Negative)
Form: Purified
Antigen:
alpha-Fetoprotein/AFP
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
AFP
Immunogen:
Alpha feto protein (AFP) Purified from serum of a hepatoma patient (Uniprot: P02771)
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
It recognizes an oncofetal glycoprotein with a single chain of 70kDa, which is identified as alpha fetoprotein (AFP) (ISOBM TD-2 workshop). This monoclonal antibody is highly specific to AFP and shows no cross-reaction with other oncofetal antigens or serum albumin. AFP is normally synthesized in the liver, intestinal tract, and yolk sac of the fetus. Antibody to AFP has been shown to be useful in detecting hepatocellular carcinomas (HCC) and germ cell neoplasms, especially yolk sac tumors.
Content And Storage:
Store at 4C.
Isotype:
IgG1 κ
Applications:
Immunohistochemistry (Paraffin)
Clone:
C2
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
Alpha-1-fetoprotein, Alpha-fetoglobulin, alpha-fetoprotein, FETA, HP, HPAFP
Host Species:
Mouse
Molecular Weight of Antigen:
70 kDa
Quantity:
7 mL
Research Discipline:
Cancer, Cancer Stem Cells, GPCR, Stem Cell Markers, Tumor Biomarkers
Gene ID (Entrez):
174
Target Species:
Human, Mouse, Bovine (Negative), Canine (Negative), Rat (Negative)
Form:
Purified
Antigen: HLA DRB1
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: HLA-DRB1
Immunogen: Activated human peripheral blood mononuclear cells
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This monoclonal antibody reacts with a 28kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each others respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
Content And Storage: Store at 4C.
Isotype: IgG2b κ
Applications: Immunohistochemistry (Paraffin)
Clone: SPM288
Dilution: Immunohistochemistry-Paraffin
Gene Alias: Clone P2-beta-3, DR1, DR-1, DR12, DR-12, DR13, DR-13, DR14, DR-14, DR16, DR-16, DR4, DR-4, DR5, DR-5, DR7, DR-7, DR8, DR-8, DR9, DR-9, DRB1, DRw10, DRw11, DRw8, DW2.2/DR2.2, FLJ75017, FLJ76359, HLA class II antigen beta chain, HLA class II histocompatibility antigen, DR-1 beta chain, HLA-DR1B, HLA-DRB, HLA-DRB1*, HLA-DRB2, HLA-DR-beta 1, human leucocyte antigen DRB1, leucocyte antigen DR beta 1 chain, leucocyte antigen DRB1, lymphocyte antigen DRB1, major histocompatibility complex, class II, DR beta 1, MHC class II antigen DRB1*1, MHC class II antigen DRB1*10, MHC class II antigen DRB1*11, MHC class II antigen DRB1*12, MHC class II antigen DRB1*13, MHC class II antigen DRB1*14, MHC class II antigen DRB1*15, MHC class II antigen DRB1*16, MHC class II antigen DRB1*3, MHC class II antigen DRB1*4, MHC class II antigen DRB1*7, MHC class II antigen DRB1*8, MHC class II antigen DRB1*9, MHC class II antigen HLA-DR13, MHC class II HLA-DR beta 1 chain, MHC class II HLA-DR-beta cell surface gly
Host Species: Mouse
Molecular Weight of Antigen: __
Quantity: 7 mL
Research Discipline: Asthma, Immunology
Gene ID (Entrez): 3123
Target Species: Human, Monkey, Mouse (Negative)
Form: Purified
Antigen:
HLA DRB1
Classification:
Monoclonal
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
HLA-DRB1
Immunogen:
Activated human peripheral blood mononuclear cells
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This monoclonal antibody reacts with a 28kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each others respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36kDa alpha (heavy) chain and a 28kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4+ T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
Content And Storage:
Store at 4C.
Isotype:
IgG2b κ
Applications:
Immunohistochemistry (Paraffin)
Clone:
SPM288
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
Clone P2-beta-3, DR1, DR-1, DR12, DR-12, DR13, DR-13, DR14, DR-14, DR16, DR-16, DR4, DR-4, DR5, DR-5, DR7, DR-7, DR8, DR-8, DR9, DR-9, DRB1, DRw10, DRw11, DRw8, DW2.2/DR2.2, FLJ75017, FLJ76359, HLA class II antigen beta chain, HLA class II histocompatibility antigen, DR-1 beta chain, HLA-DR1B, HLA-DRB, HLA-DRB1*, HLA-DRB2, HLA-DR-beta 1, human leucocyte antigen DRB1, leucocyte antigen DR beta 1 chain, leucocyte antigen DRB1, lymphocyte antigen DRB1, major histocompatibility complex, class II, DR beta 1, MHC class II antigen DRB1*1, MHC class II antigen DRB1*10, MHC class II antigen DRB1*11, MHC class II antigen DRB1*12, MHC class II antigen DRB1*13, MHC class II antigen DRB1*14, MHC class II antigen DRB1*15, MHC class II antigen DRB1*16, MHC class II antigen DRB1*3, MHC class II antigen DRB1*4, MHC class II antigen DRB1*7, MHC class II antigen DRB1*8, MHC class II antigen DRB1*9, MHC class II antigen HLA-DR13, MHC class II HLA-DR beta 1 chain, MHC class II HLA-DR-beta cell surface gly
Host Species:
Mouse
Molecular Weight of Antigen:
__
Quantity:
7 mL
Research Discipline:
Asthma, Immunology
Gene ID (Entrez):
3123
Target Species:
Human, Monkey, Mouse (Negative)
Form:
Purified