Cytokeratin, pan Antibody (AE-1/AE-3) - IHC-Prediluted, Novus Biologicals™
Manufacturer: Novus Biologicals
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP248225-Each-of-1 | In Stock | ₹ 45,860.16 |
NBP248225 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,860.16
GST (18%): ₹ 8,254.829
Total Price: ₹ 54,114.989
Antigen
pan Cytokeratin
Classification
Monoclonal
Conjugate
Unconjugated
Formulation
10 mM PBS with 0.05% BSA with 0.05% Sodium Azide
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.
Content And Storage
Store at 4C.
Isotype
IgG1 κ
Applications
Immunohistochemistry, Immunohistochemistry (Paraffin)
Clone
AE-1/AE-3
Dilution
Immunohistochemistry, Immunohistochemistry-Paraffin
Gene Symbols
KRT1
Immunogen
This Cytokeratin, pan Antibody (AE-1/AE-3) was developed against total keratin isolated from human epidermal callus was used as immunogen to generate the pan cytokeratin antibodies AE1 + AE3 (Woodcock-Mitchell, 1982).
Quantity
7 mL
Research Discipline
Apoptosis, Cancer, Cell Biology, Cellular Markers, Signal Transduction
Gene ID (Entrez)
3848
Target Species
Human, Mouse, Rat, Bovine, Canine, Chicken, Primate, Rabbit, Reptile, Zebrafish
Form
Purified
Related Products
Description
- Cytokeratin, pan Monoclonal specifically detects Cytokeratin, pan in Human, Mouse, Rat, Bovine, Canine, Chicken, Monkey, Rabbit, Reptile, Zebrafish samples
- It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.
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Antigen: pan Cytokeratin
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10 mM PBS with 0.05% BSA with 0.05% Sodium Azide
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8); 56.5kDa (CK10); 50kDa (CK14); 50kDa (CK15); 48kDa (CK16); 40kDa (CK19). Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.
Content And Storage: Store at 4C.
Isotype: IgG1 κ
Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
Clone: AE-1/AE-3
Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
Gene Symbols: KRT1
Immunogen: This Cytokeratin, pan Antibody (AE-1/AE-3) was developed against total keratin isolated from human epidermal callus was used as immunogen to generate the pan cytokeratin antibodies AE1 + AE3 (Woodcock-Mitchell, 1982).
Quantity: 7 mL
Research Discipline: Apoptosis, Cancer, Cell Biology, Cellular Markers, Signal Transduction
Gene ID (Entrez): 3848
Target Species: Human, Mouse, Rat, Bovine, Canine, Chicken, Primate, Rabbit, Reptile, Zebrafish
Form: Purified
Antigen: ICAM-3/CD50
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Recognizes an N-glycosylated glycoprotein of 120kDa with intra-chain disulfide bonds, identified as CD50 or ICAM-3. CD50 is the major ligand for LFA-1 (CD11a/CD18) and may have signaling role to increase adhesion. It is expressed on thymocytes and T lymphocytes and is resistant to treatment with phosphatidylinositol (PI) phospholipase C. This monoclonal antibody is excellent for staining of formalin/paraffin tissues.
Content And Storage: Store at 4C.
Isotype: IgG2b κ
Applications: Immunohistochemistry (Paraffin)
Clone: ICAM3/1019
Dilution: Immunohistochemistry-Paraffin
Gene Symbols: ICAM3
Immunogen: Recombinant human ICAM-3/CD50 protein (Uniprot: P32942)
Quantity: 7 mL
Research Discipline: Cellular Markers, Immunology
Gene ID (Entrez): 3385
Target Species: Human
Form: Purified
Antigen: Arginase 1/ARG1/liver Arginase
Classification: Monoclonal
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Host Species: Mouse
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.
Content And Storage: Store at 4C.
Isotype: IgG3 κ
Applications: Immunohistochemistry (Paraffin)
Clone: ARG1/1125
Dilution: Immunohistochemistry-Paraffin
Gene Symbols: ARG1
Immunogen: Recombinant human Arginase 1/ARG1/liver Arginase protein fragment (around aa11-97) (exact sequence is proprietary) (Uniprot: P05089)
Quantity: 7 mL
Research Discipline: Cancer, Cellular Markers, Chromatin Research, Lipid and Metabolism, Myeloid derived Suppressor Cell
Gene ID (Entrez): 383
Target Species: Human
Form: Purified