NBP248258

Melanoma Marker (MART-1 + Tyrosinase + gp100) Antibody (A103 + T311 + HMB45) - IHC-Prediluted, Novus Biologicals™

Manufacturer: Novus Biologicals

Select a Size

Pack Size SKU Availability Price
Each of 1 NBP248258-Each-of-1 In Stock ₹ 44,833.44

NBP248258 - Each of 1

₹ 44,833.44

In Stock

Quantity

1

Base Price: ₹ 44,833.44

GST (18%): ₹ 8,070.019

Total Price: ₹ 52,903.459

Antigen

Melanoma Marker (MART-1 + Tyrosinase + gp100)

Classification

Monoclonal

Conjugate

Unconjugated

Formulation

PBS with 0.05% BSA. with 0.05% Sodium Azide

Host Species

Mouse

Purification Method

Protein A or G purified

Regulatory Status

RUO

Gene ID (Entrez)

2315

Target Species

Human

Form

Purified

Applications

Immunohistochemistry (Paraffin)

Clone

A103 + T311 + HMB45

Dilution

Immunohistochemistry, Immunohistochemistry-Paraffin

Gene Alias

MART1, MART-1, melan-A, MLANA

Immunogen

Recombinant hMART-1 protein (A103); Recombinant tyrosinase protein (T311); Extract of pigmented melanoma metastases from lymph nodes (HMB45)

Quantity

7 mL

Primary or Secondary

Primary

Test Specificity

This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. The function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.

Content And Storage

Store at 4C.

Isotype

IgG1, IgG2a κ

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Description

  • Melanoma Marker (MART-1 + Tyrosinase + gp100) Monoclonal specifically detects Melanoma Marker (MART-1 + Tyrosinase + gp100) in Human samples
  • It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.

Compare Similar Items

Show Difference

Img

Novus Biologicals

NBP248258

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Antigen:
Melanoma Marker (MART-1 + Tyrosinase + gp100)

Classification:
Monoclonal

Conjugate:
Unconjugated

Formulation:
PBS with 0.05% BSA. with 0.05% Sodium Azide

Host Species:
Mouse

Purification Method:
Protein A or G purified

Regulatory Status:
RUO

Gene ID (Entrez):
2315

Target Species:
Human

Form:
Purified

Applications:
Immunohistochemistry (Paraffin)

Clone:
A103 + T311 + HMB45

Dilution:
Immunohistochemistry, Immunohistochemistry-Paraffin

Gene Alias:
MART1, MART-1, melan-A, MLANA

Immunogen:
Recombinant hMART-1 protein (A103); Recombinant tyrosinase protein (T311); Extract of pigmented melanoma metastases from lymph nodes (HMB45)

Quantity:
7 mL

Primary or Secondary:
Primary

Test Specificity:
This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. The function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.

Content And Storage:
Store at 4C.

Isotype:
IgG1, IgG2a κ

Img

Novus Biologicals

NBP248260

--


Antigen:
MFG-E8

Classification:
Monoclonal

Conjugate:
Unconjugated

Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide

Host Species:
Mouse

Purification Method:
Protein A or G purified

Regulatory Status:
RUO

Gene ID (Entrez):
4240

Target Species:
Human

Form:
Purified

Applications:
Immunohistochemistry (Paraffin)

Clone:
SPM291

Dilution:
Immunohistochemistry-Paraffin

Gene Alias:
BA46, Breast epithelial antigen BA46, EDIL1, hP47, HsT19888, lactadherin, medin, MFG1, MFG-E8, MFGM, Milk fat globule-EGF factor 8, milk fat globule-EGF factor 8 protein, O-acetyl disialoganglioside synthase, OAcGD3S, SED1, SPAG10, sperm associated antigen 10, sperm surface protein hP47

Immunogen:
Human milk fat globule membrane preparation (Uniprot: Q08431)

Quantity:
7 mL

Primary or Secondary:
Primary

Test Specificity:
Recognizes a protein of 40-45kDa, identified as human milk fat globule membrane protein (HMFG). HMFG is present on normal human breast epithelial cells and cell lines derived from breast carcinomas, as well as to the outer surface of the human milk fat globule. HMFG is considered as a differentiation marker. It is useful as specific breast epithelial marker and can also provide a tool to study the role of the cell surface in normal and neoplastic mammary development.

Content And Storage:
Store at 4C.

Isotype:
IgG1 κ

Img

Novus Biologicals

NBP248263

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Antigen:
MITF

Classification:
Monoclonal

Conjugate:
Unconjugated

Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide

Host Species:
Mouse

Purification Method:
Protein A or G purified

Regulatory Status:
RUO

Gene ID (Entrez):
4286

Target Species:
Human, Mouse (Negative), Rat (Negative)

Form:
Purified

Applications:
Immunohistochemistry (Paraffin)

Clone:
C5/D5

Dilution:
Immunohistochemistry-Paraffin

Gene Alias:
BHLHE32, bHLHe32MI, Class E basic helix-loop-helix protein 32, microphthalmia-associated transcription factor, Waardenburg syndrome, type 2A, WS2A

Immunogen:
NH2 terminus fragment of human MITF (Uniprot: O75030 )

Quantity:
7 mL

Primary or Secondary:
Primary

Test Specificity:
MITF (microphthalmia transcription factor) is a basic helix-loop-helix-leucine-zipper (bHLH-Zip) transcription factor that regulates the development and survival of melanocytes and retinal pigment epithelium, and also is involved in transcription of pigmentation enzyme genes such as tyrosinase TRP1 and TRP2. MITF has been shown to be phosphorylated by MAP kinase in response to c-kit activation, resulting in upregulation of MITF transcriptional activity. Mutations of the MITF gene are associated with the autosomal dominant hereditary deafness and pigmentation condition, Waardenburg Syndrome type 2A. Multiple isoforms of MITF exist, including MITF-A, MITF-B, MITF-C, MITF-H, and MITF-M, which differ in the amino-terminal domain and in their expression patterns. The MITF-M isoform is restricted to the melanocyte cell lineage. Anti-MITF, D5, recognizes a nuclear protein, which is expressed in the majority of primary and metastatic epithelioid malignant melanomas as well as in normal melanocytes, benign nevi and dysplastic nevi.

Content And Storage:
Store at 4C.

Isotype:
IgG1 κ

Img

Novus Biologicals

NBP248264

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Antigen:
EpCAM/TROP1

Classification:
Monoclonal

Conjugate:
Unconjugated

Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide

Host Species:
Mouse

Purification Method:
Protein A or G purified

Regulatory Status:
RUO

Gene ID (Entrez):
4072

Target Species:
Human, Mouse, Rat

Form:
Purified

Applications:
Immunohistochemistry, Immunohistochemistry (Paraffin), Peptide Array

Clone:
EGP40/1110

Dilution:
Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array

Gene Alias:
17-1A, 323/A3, ACSTD1, antigen identified by monoclonal AUA1, CD326 antigen, Cell surface glycoprotein Trop-1, chromosome 4, surface marker (35kD glycoprotein), DIAR5, EGP, EGP-2, EGP314, EGP40, EpCAM, epithelial cell adhesion molecule, Epithelial cell surface antigen, Epithelial glycoprotein, Epithelial glycoprotein 314, ESA, GA733-2EGP34, hEGP314, HNPCC8, KS 1/4 antigen, KS1/4, KSAHEA125, M1S2, M4S1Ly74, Major gastrointestinal tumor-associated protein GA733-2, MIC18MH99, MOC31, TACST-1, TACSTD1, TROP1CD326, Tumor-associated calcium signal transducer 1CO-17A

Immunogen:
Recombinant fragment from cytoplasmic domain (around aa 289-314) of human EpCAM/TROP1 (exact sequence is proprietary) (Uniprot: P16422 )

Quantity:
7 mL

Primary or Secondary:
Primary

Test Specificity:
EGP40 is a 40-43kDa transmembrane epithelial glycoprotein, also identified as epithelial specific antigen (ESA), or epithelial cellular adhesion molecule (Ep-CAM). It is expressed on baso-lateral cell surface in most simple epithelia and a vast majority of carcinomas. This antibody has been used to distinguish adenocarcinoma from pleural mesothelioma and hepatocellular carcinoma. This antibody is also useful in distinguishing serous carcinomas of the ovary from mesothelioma.

Content And Storage:
Store at 4C.

Isotype:
IgG2b κ