NBP248469
TIMP-3 Antibody - IHC-Prediluted, Novus Biologicals™
Manufacturer: Novus Biologicals
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | NBP248469-Each-of-1 | In Stock | ₹ 44,833.44 |
NBP248469 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,833.44
GST (18%): ₹ 8,070.019
Total Price: ₹ 52,903.459
Antigen
TIMP-3
Classification
Polyclonal
Dilution
Immunohistochemistry-Paraffin
Gene Alias
HSMRK222, K222, K222TA2, metalloproteinase inhibitor 3, MIG-5 protein, Protein MIG-5, pseudoinflammatory), SFD, TIMP metallopeptidase inhibitor 3, TIMP-3, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, Tissue inhibitor of metalloproteinases 3
Host Species
Rabbit
Molecular Weight of Antigen
30 kDa
Quantity
7 mL
Research Discipline
Angiogenesis, Apoptosis, Cancer, Hypoxia, Metastasis, Vision
Gene ID (Entrez)
7078
Target Species
Human, Bovine, Canine, Equine, Sheep
Form
Purified
Applications
Immunohistochemistry (Paraffin)
Conjugate
Unconjugated
Formulation
PBS with 0.05% BSA. with 0.05% Sodium Azide
Gene Symbols
TIMP3
Immunogen
TIMP-3 (aa175-211) (Uniprot: P35625)
Purification Method
Protein A purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.
Content And Storage
Store at 4C.
Isotype
IgG
Related Products
Description
- TIMP-3 Polyclonal specifically detects TIMP-3 in Human, Mouse, Rat, Bovine, Canine, Equine samples
- It is validated for Immunohistochemistry, Immunohistochemistry-Paraffin.
Compare Similar Items
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Antigen: TIMP-3
Classification: Polyclonal
Dilution: Immunohistochemistry-Paraffin
Gene Alias: HSMRK222, K222, K222TA2, metalloproteinase inhibitor 3, MIG-5 protein, Protein MIG-5, pseudoinflammatory), SFD, TIMP metallopeptidase inhibitor 3, TIMP-3, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, Tissue inhibitor of metalloproteinases 3
Host Species: Rabbit
Molecular Weight of Antigen: 30 kDa
Quantity: 7 mL
Research Discipline: Angiogenesis, Apoptosis, Cancer, Hypoxia, Metastasis, Vision
Gene ID (Entrez): 7078
Target Species: Human, Bovine, Canine, Equine, Sheep
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
Gene Symbols: TIMP3
Immunogen: TIMP-3 (aa175-211) (Uniprot: P35625)
Purification Method: Protein A purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.
Content And Storage: Store at 4C.
Isotype: IgG
Antigen:
TIMP-3
Classification:
Polyclonal
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
HSMRK222, K222, K222TA2, metalloproteinase inhibitor 3, MIG-5 protein, Protein MIG-5, pseudoinflammatory), SFD, TIMP metallopeptidase inhibitor 3, TIMP-3, tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy, Tissue inhibitor of metalloproteinases 3
Host Species:
Rabbit
Molecular Weight of Antigen:
30 kDa
Quantity:
7 mL
Research Discipline:
Angiogenesis, Apoptosis, Cancer, Hypoxia, Metastasis, Vision
Gene ID (Entrez):
7078
Target Species:
Human, Bovine, Canine, Equine, Sheep
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Formulation:
PBS with 0.05% BSA. with 0.05% Sodium Azide
Gene Symbols:
TIMP3
Immunogen:
TIMP-3 (aa175-211) (Uniprot: P35625)
Purification Method:
Protein A purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
TIMP3 (tissue inhibitor of metalloproteinases 3), along with family members TIMP1, TIMP2, and TIMP4, are inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix (ECM). An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. TIMP s inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes.
Content And Storage:
Store at 4C.
Isotype:
IgG
Antigen: TNF-alpha
Classification: Monoclonal
Dilution: Immunohistochemistry-Paraffin
Gene Alias: APC1 protein, Cachectin, DIF, TNF, monocyte-derived, TNF-a, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
Host Species: Mouse
Molecular Weight of Antigen: 17 kDa
Quantity: 7 mL
Research Discipline: Adaptive Immunity, Asthma, Autoimmune Diseases, Autophagy, Cancer, Cytokine Research, Diabetes Research, Immune System Diseases, Immunology, Innate Immunity
Gene ID (Entrez): 7124
Target Species: Human, Rat
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: TNF
Immunogen: Recombinant full-length human TNF-alpha protein (Uniprot: P01375)
Purification Method: Protein L or PEG purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This MAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17kDa free molecule, or as a 26kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Content And Storage: Store at 4C.
Isotype: IgM κ
Antigen:
TNF-alpha
Classification:
Monoclonal
Dilution:
Immunohistochemistry-Paraffin
Gene Alias:
APC1 protein, Cachectin, DIF, TNF, monocyte-derived, TNF-a, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
Host Species:
Mouse
Molecular Weight of Antigen:
17 kDa
Quantity:
7 mL
Research Discipline:
Adaptive Immunity, Asthma, Autoimmune Diseases, Autophagy, Cancer, Cytokine Research, Diabetes Research, Immune System Diseases, Immunology, Innate Immunity
Gene ID (Entrez):
7124
Target Species:
Human, Rat
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
TNF
Immunogen:
Recombinant full-length human TNF-alpha protein (Uniprot: P01375)
Purification Method:
Protein L or PEG purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This MAb recognizes human 17-26kDa protein, which is identified as cytokine TNF-alpha (Tumor Necrosis Factor-alpha). TNF-alpha can be expressed as a 17kDa free molecule, or as a 26kDa membrane protein. TNF-alpha is a protein secreted by lipopolysaccharide-stimulated macrophages, and causes tumor necrosis when injected into tumor bearing mice. TNF alpha causes cytolysis of certain transformed cells, being synergistic with interferon gamma in its cytotoxicity. Although it has little effect on many cultured normal human cells, TNF alpha appears to be directly toxic to vascular endothelial cells. Other actions of TNF alpha include stimulating growth of human fibroblasts and other cell lines, activating polymorphonuclear neutrophils and osteoclasts, and induction of interleukin 1, prostaglandin E2 and collagenase production. TNF alpha is currently being evaluated in treatment of certain cancers and AIDS Related Complex.
Content And Storage:
Store at 4C.
Isotype:
IgM κ
Antigen: TOP1MT
Classification: Monoclonal
Dilution: Immunohistochemistry, Immunohistochemistry-Paraffin
Gene Alias: mitochondrial, mitochondrial DNA topoisomerase I, topoisomerase (DNA) I, mitochondrial
Host Species: Mouse
Molecular Weight of Antigen: 70 kDa
Quantity: 7 mL
Research Discipline: __
Gene ID (Entrez): 116447
Target Species: Human
Form: Purified
Applications: Immunohistochemistry, Immunohistochemistry (Paraffin)
Conjugate: Unconjugated
Formulation: 10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols: TOP1MT
Immunogen: Recombinant full-length human TOP1MT protein (Uniprot: Q969P6 )
Purification Method: Protein A or G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
Content And Storage: Store at 4C.
Isotype: IgG2b κ
Antigen:
TOP1MT
Classification:
Monoclonal
Dilution:
Immunohistochemistry, Immunohistochemistry-Paraffin
Gene Alias:
mitochondrial, mitochondrial DNA topoisomerase I, topoisomerase (DNA) I, mitochondrial
Host Species:
Mouse
Molecular Weight of Antigen:
70 kDa
Quantity:
7 mL
Research Discipline:
__
Gene ID (Entrez):
116447
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry, Immunohistochemistry (Paraffin)
Conjugate:
Unconjugated
Formulation:
10mM PBS and 0.05% BSA with 0.05% Sodium Azide
Gene Symbols:
TOP1MT
Immunogen:
Recombinant full-length human TOP1MT protein (Uniprot: Q969P6 )
Purification Method:
Protein A or G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.
Content And Storage:
Store at 4C.
Isotype:
IgG2b κ
Antigen: 5'-Nucleotidase/CD73
Classification: Monoclonal
Dilution: Flow Cytometry 1:500, Immunohistochemistry, Immunohistochemistry-Paraffin reported by customer review, Immunohistochemistry-Frozen reported in scientific literature (PMID 1989648), Flow (Cell Surface)
Gene Alias: 5' nucleotidase (CD73), 5'-NT, 5'-nucleotidase, ecto (CD73), ad2 anti cd73, ad2 cd73, CD73, CD73 antigen, E5NT, EC 3.1.3.5, Ecto-5'-nucleotidase, eN, eNT, NT, NT55'-nucleotidase, NTE, Purine 5-Prime-Nucleotidase
Host Species: Mouse
Molecular Weight of Antigen: __
Quantity: 0.1 mL
Research Discipline: Lipid and Metabolism, Myeloid derived Suppressor Cell
Gene ID (Entrez): 4907
Target Species: Human
Form: Purified
Applications: Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Conjugate: Unconjugated
Formulation: PBS with 0.02% Sodium Azide
Gene Symbols: NT5E
Immunogen: Human CD73 [UniProt# P21589]
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype: IgG1 κ
Antigen:
5'-Nucleotidase/CD73
Classification:
Monoclonal
Dilution:
Flow Cytometry 1:500, Immunohistochemistry, Immunohistochemistry-Paraffin reported by customer review, Immunohistochemistry-Frozen reported in scientific literature (PMID 1989648), Flow (Cell Surface)
Gene Alias:
5' nucleotidase (CD73), 5'-NT, 5'-nucleotidase, ecto (CD73), ad2 anti cd73, ad2 cd73, CD73, CD73 antigen, E5NT, EC 3.1.3.5, Ecto-5'-nucleotidase, eN, eNT, NT, NT55'-nucleotidase, NTE, Purine 5-Prime-Nucleotidase
Host Species:
Mouse
Molecular Weight of Antigen:
__
Quantity:
0.1 mL
Research Discipline:
Lipid and Metabolism, Myeloid derived Suppressor Cell
Gene ID (Entrez):
4907
Target Species:
Human
Form:
Purified
Applications:
Flow Cytometry, Immunohistochemistry, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen)
Conjugate:
Unconjugated
Formulation:
PBS with 0.02% Sodium Azide
Gene Symbols:
NT5E
Immunogen:
Human CD73 [UniProt# P21589]
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Isotype:
IgG1 κ