PA129159
Caspase 8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PA129159-Each-of-1 | In Stock | ₹ 50,480.40 |
PA129159 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,480.40
GST (18%): ₹ 9,086.472
Total Price: ₹ 59,566.872
Antigen
Caspase 8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Casp8
Gene Alias
ALPS2B; apoptosis-related cysteine peptidase; apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; CASP8; CASP-8; caspase 8; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis-related cysteine protease; Caspase8; caspase-8; Caspase-8 precursor; Caspase-8 subunit p10; Caspase-8 subunit p18; EC 3.4.22.61; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; Fas-linked ICE-like protease; FLICE; FLJ17672; ICE8; ICE-like apoptotic protease 5; MACH; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MCH5; MGC78473; MORT1-associated ced-3 homolog; OTTHUMP00000163720; OTTHUMP00000165063; OTTHUMP00000206557; OTTHUMP00000206581
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
12370, 64044, 841
Content And Storage
4° C, do not freeze
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
10mM PBS with 0.2% BSA and 0.1% sodium azide
Gene Accession No.
O89110, Q14790, Q9JHX4
Gene Symbols
Casp8
Immunogen
The epitope corresponding to amino acids 217-350 mapping within the caspase-8 p18 subunit of human origin
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: Jurkat Cells, Stomach
- Caspase 8 (CASP8) is a member of the cysteine-aspartic acid protease (caspase) family
- Sequential activation of caspases play a central role in the execution-phase of cell apoptosis
- Caspases exist as inactive proenzymes composed of a pro-domain, a large protease subunit, and a small protease subunit
- Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits
- Caspase 8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli
- The N-terminal FADD-like death effector domain of Caspase 8 suggests that it may interact with Fas-interacting protein FADD
- Caspase 8 was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases
- Caspase 8 binds to the death effector domain (DED) of FADD through an analogous DED domain present in tandem in the pro-form of the Caspase 8 protein
- Activated Caspase 8 then activates other downstream caspases including Caspase 9, thereby committing the cell to undergo apoptosis
- In addition, Caspase 8 also reacts with Jurkat cells and Tonsil
- Overexpression of Caspase 8 induces apoptosis, which can be blocked by inhibitors specific for the ICE family
- Many alternatively spliced transcript variants encoding different isoforms have been described for Caspase 8, however, not all variants have had their full-length sequences determined.
Compare Similar Items
Show Difference
Antigen: Caspase 8
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Casp8
Gene Alias: ALPS2B; apoptosis-related cysteine peptidase; apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; CASP8; CASP-8; caspase 8; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis-related cysteine protease; Caspase8; caspase-8; Caspase-8 precursor; Caspase-8 subunit p10; Caspase-8 subunit p18; EC 3.4.22.61; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; Fas-linked ICE-like protease; FLICE; FLJ17672; ICE8; ICE-like apoptotic protease 5; MACH; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MCH5; MGC78473; MORT1-associated ced-3 homolog; OTTHUMP00000163720; OTTHUMP00000165063; OTTHUMP00000206557; OTTHUMP00000206581
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 12370, 64044, 841
Content And Storage: 4° C, do not freeze
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: 10mM PBS with 0.2% BSA and 0.1% sodium azide
Gene Accession No.: O89110, Q14790, Q9JHX4
Gene Symbols: Casp8
Immunogen: The epitope corresponding to amino acids 217-350 mapping within the caspase-8 p18 subunit of human origin
Quantity: 500 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
Caspase 8
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Casp8
Gene Alias:
ALPS2B; apoptosis-related cysteine peptidase; apoptotic cysteine protease; Apoptotic protease Mch-5; CAP4; CASP8; CASP-8; caspase 8; caspase 8, apoptosis-related cysteine peptidase; caspase 8, apoptosis-related cysteine protease; Caspase8; caspase-8; Caspase-8 precursor; Caspase-8 subunit p10; Caspase-8 subunit p18; EC 3.4.22.61; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; Fas-linked ICE-like protease; FLICE; FLJ17672; ICE8; ICE-like apoptotic protease 5; MACH; MACH-alpha-1/2/3 protein; MACH-beta-1/2/3/4 protein; MCH5; MGC78473; MORT1-associated ced-3 homolog; OTTHUMP00000163720; OTTHUMP00000165063; OTTHUMP00000206557; OTTHUMP00000206581
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
12370, 64044, 841
Content And Storage:
4° C, do not freeze
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
10mM PBS with 0.2% BSA and 0.1% sodium azide
Gene Accession No.:
O89110, Q14790, Q9JHX4
Gene Symbols:
Casp8
Immunogen:
The epitope corresponding to amino acids 217-350 mapping within the caspase-8 p18 subunit of human origin
Quantity:
500 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: CX3CL1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Cx3cl1
Gene Alias: A-152E5.2; AB030188; ABCD-3; Acc1; AI848747; C3Xkine; chemokine (C-X3-C motif) ligand 1; CX3C; CX3C membrane-anchored chemokine; C-X3-C motif chemokine 1; C-X3-C motif chemokine ligand 1; Cx3cl1; CXC3; CXC3C; D8Bwg0439e; Fkn; Fractalkine; neurotactin; NTN; NTT; Processed fractalkine; SCYD1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D, 1; small-inducible cytokine D1
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 20312, 6376, 89808
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.1% sodium azide; pH 7.2
Gene Accession No.: O35188, O55145, P78423
Gene Symbols: Cx3cl1
Immunogen: Recombinant fragment - human CX3CL1 (fractalkine)
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
CX3CL1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Cx3cl1
Gene Alias:
A-152E5.2; AB030188; ABCD-3; Acc1; AI848747; C3Xkine; chemokine (C-X3-C motif) ligand 1; CX3C; CX3C membrane-anchored chemokine; C-X3-C motif chemokine 1; C-X3-C motif chemokine ligand 1; Cx3cl1; CXC3; CXC3C; D8Bwg0439e; Fkn; Fractalkine; neurotactin; NTN; NTT; Processed fractalkine; SCYD1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D, 1; small-inducible cytokine D1
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
20312, 6376, 89808
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.1% sodium azide; pH 7.2
Gene Accession No.:
O35188, O55145, P78423
Gene Symbols:
Cx3cl1
Immunogen:
Recombinant fragment - human CX3CL1 (fractalkine)
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Antigen: Bovine Serum Albumin
Classification: Polyclonal
Conjugate: FITC
Gene: ALB
Gene Alias: ALB; ALB protein; Alb1; Alb-1; albumin; albumin (32 AA); albumin (AA 34); albumin 1; Albza; ANALBA; Bos d 6; bovine albumin; bovine serum albumin; BSA; cell growth inhibiting protein 42; FDAH; GIG20; GIG42; growth-inhibiting protein 20; MGC179277; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619; PRO2675; Serum albumin; UNQ696/PRO1341
Host Species: Sheep
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 280717
Content And Storage: 4° C, store in dark
Form: Liquid
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: 1 mg/mL
Formulation: PBS with 0.2% ovalbumin and 0.1% sodium azide
Gene Accession No.: P02769
Gene Symbols: ALB
Immunogen: Sheep were immunized with highly purified Bovine Serum Albumin in Freund's adjuvant. After multiple immunizations, serum was collected, antibodies were isolated by immunoaffinity chromatography.
Quantity: 1 mg
Primary or Secondary: Primary
Target Species: Bovine
Product Type: Antibody
Isotype: IgG
Antigen:
Bovine Serum Albumin
Classification:
Polyclonal
Conjugate:
FITC
Gene:
ALB
Gene Alias:
ALB; ALB protein; Alb1; Alb-1; albumin; albumin (32 AA); albumin (AA 34); albumin 1; Albza; ANALBA; Bos d 6; bovine albumin; bovine serum albumin; BSA; cell growth inhibiting protein 42; FDAH; GIG20; GIG42; growth-inhibiting protein 20; MGC179277; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619; PRO2675; Serum albumin; UNQ696/PRO1341
Host Species:
Sheep
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
280717
Content And Storage:
4° C, store in dark
Form:
Liquid
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
1 mg/mL
Formulation:
PBS with 0.2% ovalbumin and 0.1% sodium azide
Gene Accession No.:
P02769
Gene Symbols:
ALB
Immunogen:
Sheep were immunized with highly purified Bovine Serum Albumin in Freund's adjuvant. After multiple immunizations, serum was collected, antibodies were isolated by immunoaffinity chromatography.
Quantity:
1 mg
Primary or Secondary:
Primary
Target Species:
Bovine
Product Type:
Antibody
Isotype:
IgG
Antigen: Bovine Serum Albumin
Classification: Polyclonal
Conjugate: Unconjugated
Gene: ALB
Gene Alias: ALB; ALB protein; Alb1; Alb-1; albumin; albumin (32 AA); albumin (AA 34); albumin 1; Albza; ANALBA; Bos d 6; bovine albumin; bovine serum albumin; BSA; cell growth inhibiting protein 42; FDAH; GIG20; GIG42; growth-inhibiting protein 20; MGC179277; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619; PRO2675; Serum albumin; UNQ696/PRO1341
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 280717
Content And Storage: 4° C, do not freeze
Form: Liquid
Applications: ELISA, Immunoprecipitation, Western Blot
Concentration: 1.0 mg/mL
Formulation: PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.: P02769
Gene Symbols: ALB
Immunogen: Highly purified Bovine Serum Albumin in Freund's adjuvant
Quantity: 1 mL
Primary or Secondary: Primary
Target Species: Bovine
Product Type: Antibody
Isotype: IgG
Antigen:
Bovine Serum Albumin
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
ALB
Gene Alias:
ALB; ALB protein; Alb1; Alb-1; albumin; albumin (32 AA); albumin (AA 34); albumin 1; Albza; ANALBA; Bos d 6; bovine albumin; bovine serum albumin; BSA; cell growth inhibiting protein 42; FDAH; GIG20; GIG42; growth-inhibiting protein 20; MGC179277; PRO0883; PRO0903; PRO1341; PRO1708; PRO2044; PRO2619; PRO2675; Serum albumin; UNQ696/PRO1341
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
280717
Content And Storage:
4° C, do not freeze
Form:
Liquid
Applications:
ELISA, Immunoprecipitation, Western Blot
Concentration:
1.0 mg/mL
Formulation:
PBS with 0.09% sodium azide; pH 7.2
Gene Accession No.:
P02769
Gene Symbols:
ALB
Immunogen:
Highly purified Bovine Serum Albumin in Freund's adjuvant
Quantity:
1 mL
Primary or Secondary:
Primary
Target Species:
Bovine
Product Type:
Antibody
Isotype:
IgG