PA186558

Phospho-NMDAR2B (Tyr1472) Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PA186558-Each-of-1 In Stock ₹ 50,223.72

PA186558 - Each of 1

₹ 50,223.72

In Stock

Quantity

1

Base Price: ₹ 50,223.72

GST (18%): ₹ 9,040.27

Total Price: ₹ 59,263.99

Antigen

Phospho-NMDAR2B (Tyr1472)

Classification

Polyclonal

Formulation

0.01M HEPES with 0.01% BSA, 50% glycerol and 0.09% sodium azide; pH 7.5

Gene Accession No.

Q00960

Gene Symbols

GRIN2B

Immunogen

Synthetic phosphopeptide corresponding to an amino acid sequence within the NR2B subunit of the NMDA receptor, which includes phosphorylated Tyr1472.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Rat

Product Type

Antibody

Isotype

IgG

Applications

Western Blot

Conjugate

Unconjugated

Gene

GRIN2B

Gene Alias

AW490526; EIEE27; GluN2B; GluRepsilon2; glutamate [NMDA] receptor subunit epsilon-2; glutamate ionotropic receptor NMDA type subunit 2B; glutamate receptor; glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B; glutamate receptor, ionotropic, NMDA2B (epsilon 2); glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN 2B; GRIN2B; HGNC:4586; hNR 3; hNR3; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B; MGC142178; MGC142180; MRD6; Nmdar2b; NMDE2; NME2; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 2B; N-methyl-D-aspartate receptor subunit 3; NR2B; NR3

Host Species

Rabbit

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

24410

Content And Storage

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form

Liquid

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Description

  • PA1-86558 specifically recognizes the 180 kDa NR2B subunit of the NMDA (N-methyl-D-aspartate) receptor when phosphorylated at Tyr1472
  • Predicted to react with bovine, chicken, dog, human, monkey, mouse and zebrafish based on sequence homology
  • For the detection of phosphoproteins, tyrosine phosphatase inhibitors such as 1mM sodium orthovanadate should be added to the sample buffer
  • Milk or other casein-based blocking solutions are not recommended as casein is a phosphoprotein and its use can result in high background
  • In Western blot, this antibody detects a band at ∽180 kDa in rat brain hippocampal lysate
  • In Western blot, this antibody also labels proteins of 65kDa and 115kDa
  • NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors
  • NMDA receptors (NMDAR) have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning
  • NMDAR play a role in neuronal development and has been implicated in several disorders of the central nervous system including Alzheimer’s Disease, epilepsy and ischemic neuronal cell death
  • Overexpression of the NR2B subunit of the receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression
  • Tyr1472 on NR2B is phosphorylated and this may lead to the increased expression of the NMDAR at the synapse that plays a role in synaptic plasticity
  • NMDR2B is a heterotrimer comprised of seven enetically encoded and differentially expressed subunits that include NR1, NR2 and NR3
  • Diseases associated with the dysfunction of NMDAR2B include epileptic encephalopathy, autosomal dominant 6-related mental retardation.

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Show Difference

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Thermo Scientific

PA186558

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Antigen:
Phospho-NMDAR2B (Tyr1472)

Classification:
Polyclonal

Formulation:
0.01M HEPES with 0.01% BSA, 50% glycerol and 0.09% sodium azide; pH 7.5

Gene Accession No.:
Q00960

Gene Symbols:
GRIN2B

Immunogen:
Synthetic phosphopeptide corresponding to an amino acid sequence within the NR2B subunit of the NMDA receptor, which includes phosphorylated Tyr1472.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Rat

Product Type:
Antibody

Isotype:
IgG

Applications:
Western Blot

Conjugate:
Unconjugated

Gene:
GRIN2B

Gene Alias:
AW490526; EIEE27; GluN2B; GluRepsilon2; glutamate [NMDA] receptor subunit epsilon-2; glutamate ionotropic receptor NMDA type subunit 2B; glutamate receptor; glutamate receptor ionotropic, NMDA 2B; glutamate receptor subunit epsilon-2; glutamate receptor, ionotropic, NMDA2B; glutamate receptor, ionotropic, NMDA2B (epsilon 2); glutamate receptor, ionotropic, N-methyl D-aspartate 2B; GRIN 2B; GRIN2B; HGNC:4586; hNR 3; hNR3; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B; MGC142178; MGC142180; MRD6; Nmdar2b; NMDE2; NME2; N-methyl D-aspartate receptor 2B; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 2B; N-methyl-D-aspartate receptor subunit 3; NR2B; NR3

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
24410

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Img

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PA186602

--


Antigen:
alpha/beta Tubulin

Classification:
Polyclonal

Formulation:
PBS with 0.09% sodium azide; pH 7.2

Gene Accession No.:
A2AQ07, P02550, P07437, P68369, P68370, Q71U36, Q767L7, Q9H4B7

Gene Symbols:
TUBA1A, TUBB, TUBB1

Immunogen:
Purified porcine brain tubulin.

Quantity:
500 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Porcine, Rat

Product Type:
Antibody

Isotype:
IgG

Applications:
ELISA, Western Blot

Conjugate:
Unconjugated

Gene:
TUBB1

Gene Alias:
2810484G07Rik; Alpha-tubulin 1; Alpha-tubulin 3; Alpha-tubulin isotype M-alpha-1; B-ALPHA-1; beta 5-tubulin; beta Ib tubulin; CDCBM6; CSCSC1; Detyrosinated tubulin alpha-1A chain; FLJ30169; H2 ALPHA; hum-a-tub1; hum-a-tub2; LIS3; M(beta)1; M40; OK/SW-cl.56; Talpha1 alpha-tubulin; Tuba1; Tuba-1; TUBA1A; TUBA3; TUBB; TUBB1; TUBB2A; TUBB5; Tubulin alpha; tubulin alpha 1a; tubulin alpha 3; tubulin alpha-1 chain; Tubulin alpha-1A chain; tubulin alpha-3 chain; Tubulin B-alpha-1; tubulin beta; tubulin beta 1 class VI; tubulin beta chain; tubulin beta class I; tubulin beta-1 chain; Tubulin beta-5 chain; tubulin, alpha 1; tubulin, alpha 1A; tubulin, alpha, brain-specific; tubulin, beta 1 class VI; tubulin, beta 2A class IIa; tubulin, beta class I; tubulin, beta family 1; tubulin, beta polypeptide; a/β-tubulin

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
100134983, 100135051, 203068, 22142, 545486, 64158, 679312, 733686, 7846, 81027

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Form:
Liquid

Img

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PA186695

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Antigen:
Rat Albumin

Classification:
Polyclonal

Formulation:
PBS with 0.09% sodium azide

Gene Accession No.:
P02769, P02770

Gene Symbols:
Alb

Immunogen:
Native protein.

Quantity:
1 mg

Primary or Secondary:
Primary

Target Species:
Bovine, Rat

Product Type:
Antibody

Isotype:
IgG

Applications:
ELISA, Immunocytochemistry

Conjugate:
FITC

Gene:
Alb

Gene Alias:
Alb; ALB protein; Alb1; albumin; Albza; Bos d 6; bovine serum albumin; BSA; Serum albumin

Host Species:
Sheep

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
24186, 280717

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

Form:
Liquid

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PA186736

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Antigen:
Transferrin

Classification:
Polyclonal

Formulation:
PBS with 0.09% sodium azide; pH 7.4

Gene Accession No.:
P02787

Gene Symbols:
Tf

Immunogen:
Pure human transferrin prepared from pooled normal human serum

Quantity:
1 mL

Primary or Secondary:
Primary

Target Species:
Human

Product Type:
Antibody

Isotype:
IgG

Applications:
Immunocytochemistry

Conjugate:
FITC

Gene:
Tf

Gene Alias:
AI266983; beta-1 metal-binding globulin; Cd176; DKFZp781D0156; epididymis secretory sperm binding protein Li 71p; HEL-S-71p; HP; hpx; hypotransferrinemia with hemochromatosis; ICA; Inhibitor of carbonic anhydrase; lactoferrin; liver regeneration-related protein LRRG03; liver transferrin; LOC100146633; PICA; porcine inhibitor of carbonic anhydrase; porcine inhibitor of carbonic anhydrase precursor; PRO1400; PRO1557; PRO2086; Serotransferrin; siderophilin; TF; Tfn; TFQTL1; transferin; Transferrin; transferrin precursor; Trf

Host Species:
Sheep

Purification Method:
Protein G

Regulatory Status:
RUO

Gene ID (Entrez):
7018

Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark.

Form:
Liquid