TBK1 Recombinant Rabbit Monoclonal Antibody (10H15L13), Invitrogen™

Description

• This antibody is predicted to react with Monkey, Rat, Bovine and Dog Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling
• TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses
• NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli
• NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity
• Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB
• The IKK complex contains IKKa, IKK beta, and IKKK
• A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K
• NAK/TBK1 activates IKK beta through direct phosphorylation
• NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors
• NAK/TBK1 functions upstream of NIK and the IKK complex
• NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.