SMAD1 Recombinant Polyclonal Antibody (12HCLC), Invitrogen™

Description

• This antibody is predicted to react with equine, mouse, rabbit and rat based on sequence homology
• Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific
• They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody
• While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains
• The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production
• The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C
• elegans gene Sma
• SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways
• This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses
• In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase
• The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation
• This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation
• Alternatively spliced transcript variants encoding the same protein have been observed.