PIMA1113
MDM2 Monoclonal Antibody (IF2), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA1113-Each-of-1 | In Stock | ₹ 63,956.10 |
PIMA1113 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 63,956.10
GST (18%): ₹ 11,512.098
Total Price: ₹ 75,468.198
Antigen
MDM2
Classification
Monoclonal
Concentration
1.0 mg/mL
Formulation
PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide; pH 7.2-7.4
Gene Accession No.
Q00987
Gene Symbols
MDM2
Immunogen
Human MDM2
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2b
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immunoprecipitation, Western Blot
Clone
IF2
Conjugate
Unconjugated
Gene
MDM2
Gene Alias
1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
4193
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- This antibody recognizes the ∽90 kDa (apparent MW) MDM2 protein
- Also recognizes isoforms at ∽57 and ∽74/76 kDa
- This antibody was originally validated as part of a Thermo Scientific Cellomics High Content Screening Kit
- The antibody sold separately may have slightly different performance and may need to be further optimized for the best results
- MDM2 is a ubiquitin ligase for p53 and plays a central role in regulation of the stability of p53
- MDM2 is located on chromosome 12 on the q arm
- Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53
- Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53
- MDM2 has also been shown to negatively regulate p53 function
- MDM2 binds and inhibits transactivation role played by p53 and overexpression of MDM2 can result in the inactivation of p53 and decrease its tumor suppressor function
- Another process by which MDM2 can inactivate p53 is by degrading p53 as the protein also possesses E3 ubiquitin ligase activity
- Further, MDM2 plays important roles in apoptosis and cell cycle
- MDM2 is over expressed in a wide range of human malignancies including soft tissue carcinomas and breast cancer
- In addition to p53, MDM2 is involved in processes of cell cycle, apoptosis, and tumorigenesis through interactions with proteins that include retinoblastoma 1 and ribosomal protein L5
- More than 40 different alternatively spliced transcript variants of MDM2 have been isolated from both tumor and normal tissues.
Compare Similar Items
Show Difference
Antigen: MDM2
Classification: Monoclonal
Concentration: 1.0 mg/mL
Formulation: PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide; pH 7.2-7.4
Gene Accession No.: Q00987
Gene Symbols: MDM2
Immunogen: Human MDM2
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2b
Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immunoprecipitation, Western Blot
Clone: IF2
Conjugate: Unconjugated
Gene: MDM2
Gene Alias: 1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 4193
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
MDM2
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Formulation:
PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide; pH 7.2-7.4
Gene Accession No.:
Q00987
Gene Symbols:
MDM2
Immunogen:
Human MDM2
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2b
Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Immunoprecipitation, Western Blot
Clone:
IF2
Conjugate:
Unconjugated
Gene:
MDM2
Gene Alias:
1700007J15Rik; AA415488; ACTFS; double minute 2; double minute 2 protein; double minute 2, human homolog of; p53-binding protein; E3 ubiquitin-protein ligase Mdm2; Hdm2; HDMX; HGNC:6973; human homolog of; MDM2; Mdm-2; MDM2 oncogene, E3 ubiquitin protein ligase; Mdm2 p53 binding protein homolog; MDM2 proto-oncogene; MDM2 proto-oncogene, E3 ubiquitin protein ligase; MDM2 variant FB28; Mdm2, p53 E3 ubiquitin protein ligase homolog; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; MGC5370; MGC71221; oncoprotein Mdm2; OTTHUMP00000183490; OTTHUMP00000183492; OTTHUMP00000183494; OTTHUMP00000183495; OTTHUMP00000183496; OTTHUMP00000183497; p53 E3 ubiquitin protein ligase; p53-binding protein Mdm2; RING-type E3 ubiquitin transferase Mdm2; transformed mouse 3T3 cell double minute 2
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
4193
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Huntingtin
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.: P42858, P42859
Gene Symbols: Htt
Immunogen: Synthetic peptide conjugated to KLH via cysteine corresponding to residues C-HTLQADSVD (505-513) of Human HTT.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: 3-19
Conjugate: Unconjugated
Gene: Htt
Gene Alias: AI256365; C430023I11Rik; Hd; HD protein; HD protein homolog; Hdh; HTT; Huntingtin; huntingtin (Huntington disease); Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; huntington disease protein; huntington disease protein homolog; IT15; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Host Species: Mouse
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 15194, 3064
Content And Storage: -20°C
Form: Liquid
Antigen:
Huntingtin
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.:
P42858, P42859
Gene Symbols:
Htt
Immunogen:
Synthetic peptide conjugated to KLH via cysteine corresponding to residues C-HTLQADSVD (505-513) of Human HTT.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
3-19
Conjugate:
Unconjugated
Gene:
Htt
Gene Alias:
AI256365; C430023I11Rik; Hd; HD protein; HD protein homolog; Hdh; HTT; Huntingtin; huntingtin (Huntington disease); Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; huntington disease protein; huntington disease protein homolog; IT15; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Host Species:
Mouse
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
15194, 3064
Content And Storage:
-20°C
Form:
Liquid
Antigen: TGF beta-1
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P01137
Gene Symbols: Tgfb1
Immunogen: Full length of human TGF beta-1 (Met1-Ser390) was fused with c-terminal polyhistidine tag
Quantity: 200 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: ELISA, Western Blot
Clone: E8-4D12
Conjugate: Unconjugated
Gene: Tgfb1
Gene Alias: CED; cytokine; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; tgf beta1; TGF beta-1; TGF beta-1 protein; TGF β; TGF β 1; TGF β1; Tgfb; TGFB1; TGF-B1; Tgfb-1; TGFbeta; TGF-beta 1; TGF-beta 1 protein; TGFbeta1; TGF-beta1; TGF-beta-1; TGFβ1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta-1 proprotein; transforming growth factor beta-1; transforming growth factor β1; transforming growth factor, beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; transforming growth factor-beta I; transforming growth factor-beta-1; transforming growth factor-beta-1 precursor; unnamed protein product
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 7040
Content And Storage: -20°C
Form: Liquid
Antigen:
TGF beta-1
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P01137
Gene Symbols:
Tgfb1
Immunogen:
Full length of human TGF beta-1 (Met1-Ser390) was fused with c-terminal polyhistidine tag
Quantity:
200 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
ELISA, Western Blot
Clone:
E8-4D12
Conjugate:
Unconjugated
Gene:
Tgfb1
Gene Alias:
CED; cytokine; DPD1; LAP; Latency-associated peptide; prepro-transforming growth factor beta-1; regulatory protein; TGF b; TGF b 1; TGF beta; tgf beta 1; tgf beta1; TGF beta-1; TGF beta-1 protein; TGF β; TGF β 1; TGF β1; Tgfb; TGFB1; TGF-B1; Tgfb-1; TGFbeta; TGF-beta 1; TGF-beta 1 protein; TGFbeta1; TGF-beta1; TGF-beta-1; TGFβ1; Transforming growth factor; transforming growth factor b1; transforming growth factor beta; transforming growth factor beta 1; transforming growth factor beta-1; Transforming growth factor beta-1 proprotein; transforming growth factor beta-1 proprotein; transforming growth factor beta-1; transforming growth factor β1; transforming growth factor, beta 1; transforming growth factor, beta 1 (Camurati-Engelmann disease); transforming growth factor, beta-1; transforming growth factor-beta 1; transforming growth factor-beta I; transforming growth factor-beta-1; transforming growth factor-beta-1 precursor; unnamed protein product
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
7040
Content And Storage:
-20°C
Form:
Liquid
Antigen: beta-3 Tubulin
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide
Gene Accession No.: Q13509, Q2T9S0, Q4QRB4, Q9ERD7
Gene Symbols: LOC100341581, TUBB3
Immunogen: A synthetic peptide corresponding to amino acids 436-450 from rat neuronal specific beta-3 tubulin.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Bovine, Guinea Pig, Hamster, Human, Mouse, Porcine, Rabbit, Rat
Product Type: Antibody
Isotype: IgG2a
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: 2G10
Conjugate: Unconjugated
Gene: TUBB3
Gene Alias: 3200002H15Rik; beta 3 tubulin; beta tubulin 3; beta-4; betaIII-tubulin; CDCBM; CDCBM1; CFEOM3; CFEOM3A; class III beta-tubulin; FEOM3; I79_000194; LOC100341581; M(beta)3; M(beta)6; mc1R; melanocortin receptor 1; Neuron specific beta III Tubulin; neuron-specific class III beta-tubulin; TUBB; Tubb3; TUBB4; tubulin beta; tubulin beta 3 class III; Tubulin beta-3; tubulin beta-3 chain; Tubulin beta-4; Tubulin beta-4 chain; tubulin beta-III; tubulin, beta 3 class III; tubulin, beta, 3; tubulin, beta, 4; Unknown (protein for MGC:134115)
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 100341581, 100732882, 100760055, 10381, 106509340, 22152, 246118, 768070
Content And Storage: -20°C
Form: Liquid
Antigen:
beta-3 Tubulin
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1mg/mL BSA, 30% glycerol and 0.05% sodium azide
Gene Accession No.:
Q13509, Q2T9S0, Q4QRB4, Q9ERD7
Gene Symbols:
LOC100341581, TUBB3
Immunogen:
A synthetic peptide corresponding to amino acids 436-450 from rat neuronal specific beta-3 tubulin.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Bovine, Guinea Pig, Hamster, Human, Mouse, Porcine, Rabbit, Rat
Product Type:
Antibody
Isotype:
IgG2a
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
2G10
Conjugate:
Unconjugated
Gene:
TUBB3
Gene Alias:
3200002H15Rik; beta 3 tubulin; beta tubulin 3; beta-4; betaIII-tubulin; CDCBM; CDCBM1; CFEOM3; CFEOM3A; class III beta-tubulin; FEOM3; I79_000194; LOC100341581; M(beta)3; M(beta)6; mc1R; melanocortin receptor 1; Neuron specific beta III Tubulin; neuron-specific class III beta-tubulin; TUBB; Tubb3; TUBB4; tubulin beta; tubulin beta 3 class III; Tubulin beta-3; tubulin beta-3 chain; Tubulin beta-4; Tubulin beta-4 chain; tubulin beta-III; tubulin, beta 3 class III; tubulin, beta, 3; tubulin, beta, 4; Unknown (protein for MGC:134115)
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
100341581, 100732882, 100760055, 10381, 106509340, 22152, 246118, 768070
Content And Storage:
-20°C
Form:
Liquid