PIMA514780

Phospho-PDPK1 (Ser241) Monoclonal Antibody (K.424.2), Invitrogen™

Manufacturer: Thermo Scientific

Select a Size

Pack Size SKU Availability Price
Each of 1 PIMA514780-Each-of-1 In Stock ₹ 46,159.62

PIMA514780 - Each of 1

₹ 46,159.62

In Stock

Quantity

1

Base Price: ₹ 46,159.62

GST (18%): ₹ 8,308.732

Total Price: ₹ 54,468.352

Antigen

Phospho-PDPK1 (Ser241)

Classification

Monoclonal

Concentration

62 μg/mL

Formulation

0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5

Gene Accession No.

O15530, O55173, Q9Z2A0

Gene Symbols

Pdpk1

Immunogen

Synthetic phosphopeptide corresponding to residues around pSer241 of human PDK1

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Mouse, Rat

Product Type

Antibody

Isotype

IgG

Applications

Immunoprecipitation, Western Blot

Clone

K.424.2

Conjugate

Unconjugated

Gene

Pdpk1

Gene Alias

3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase

Host Species

Rabbit

Purification Method

Affinity chromatography

Regulatory Status

RUO

Gene ID (Entrez)

18607, 5170, 81745

Content And Storage

-20°C

Form

Liquid

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Description

  • It is not recommended to aliquot this antibody
  • PDPK1 (3 Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases
  • PDPK1 activates conventional PKC and PKC zeta through phosphorylation of critical threonine residues in the activation loop
  • PDPK1 also phosphorylates Protein Kinase B (PKB) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate
  • Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), eventually leading to the dephosphorylation and activation of glycogen synthase, and the stimulation of glycogen synthesis
  • Because of the role that PDPK1 plays in insulin-induced glycogen synthesis and PKC activation, it is a potentially important target for metabolic drug research.

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Img

Thermo Scientific

PIMA514780

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Antigen:
Phospho-PDPK1 (Ser241)

Classification:
Monoclonal

Concentration:
62 μg/mL

Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5

Gene Accession No.:
O15530, O55173, Q9Z2A0

Gene Symbols:
Pdpk1

Immunogen:
Synthetic phosphopeptide corresponding to residues around pSer241 of human PDK1

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Applications:
Immunoprecipitation, Western Blot

Clone:
K.424.2

Conjugate:
Unconjugated

Gene:
Pdpk1

Gene Alias:
3-phosphoinositide dependent protein kinase 1; 3-phosphoinositide dependent protein kinase-1; 3-phosphoinositide-dependent protein kinase 1; 3-phosphoinositide-dependent protein kinase 2 pseudogene; HGNC:8809; hPDK1; isoenzyme 1; kinase isoenzyme 1; lipoamide; mPDK1; OTTHUMP00000174525; OTTHUMP00000205076; PDK1; PDPK1; PDPK2; PDPK2P; Pkb kinase; PkB kinase like gene 1; PkB-like 1; PRO0461; Protein kinase B kinase

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
18607, 5170, 81745

Content And Storage:
-20°C

Form:
Liquid

Img

Thermo Scientific

PIMA514781

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Antigen:
RECK

Classification:
Monoclonal

Concentration:
513 μg/mL

Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5

Gene Accession No.:
O95980, Q9Z0J1

Gene Symbols:
RECK

Immunogen:
Synthetic peptide corresponding to residues surrounding Ile913 of human RECK protein

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Non-human Primate, Rat

Product Type:
Antibody

Isotype:
IgG

Applications:
Western Blot

Clone:
F.286.6

Conjugate:
Unconjugated

Gene:
RECK

Gene Alias:
hRECK; membrane-anchored glycoprotein (metastasis and invasion); membrane-anchored glycoprotein RECK; mRECK; RECK; reversion inducing cysteine rich protein with kazal motifs; reversion-inducing cysteine-rich protein with Kazal motifs; Reversion-inducing cysteine-rich protein with Kazal motifs precursor (mRECK); reversion-inducing-cysteine-rich protein with kazal motifs; ST15; suppression of tumorigenicity 15; suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs); suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs); suppressor of tumorigenicity 15 protein

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
313488, 53614, 8434

Content And Storage:
-20°C

Form:
Liquid

Img

Thermo Scientific

PIMA514782

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Antigen:
JMJD2A

Classification:
Monoclonal

Concentration:
__

Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5

Gene Accession No.:
O75164, Q8BW72

Gene Symbols:
KDM4A

Immunogen:
Synthetic peptide corresponding to the human JMJD2A protein

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Non-human Primate, Rat

Product Type:
Antibody

Isotype:
IgG

Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot

Clone:
C.37.0

Conjugate:
Unconjugated

Gene:
KDM4A

Gene Alias:
D4Ertd222e; JHDM3A; jmjC domain-containing histone demethylation protein 3A; JMJD2; JMJD2A; jumonji C domain-containing histone demethylase 3A; jumonji domain containing 2; jumonji domain containing 2A; jumonji domain-containing protein 2A; KDM4A; KIAA0677; lysine (K)-specific demethylase 4A; lysine demethylase 4A; lysine-specific demethylase 4A; mKIAA0677; TDRD14A; tudor domain containing 14A

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
230674, 313539, 9682

Content And Storage:
-20°C

Form:
Liquid

Img

Thermo Scientific

PIMA514783

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Antigen:
Drosha

Classification:
Monoclonal

Concentration:
1559 μg/mL

Formulation:
0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5

Gene Accession No.:
Q5HZJ0, Q9NRR4

Gene Symbols:
DROSHA

Immunogen:
Synthetic peptide corresponding to residues surrounding Gly953 of human Drosha

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Product Type:
Antibody

Isotype:
IgG

Applications:
Immunoprecipitation, Western Blot

Clone:
K.417.2

Conjugate:
Unconjugated

Gene:
DROSHA

Gene Alias:
1110013A17Rik; AI874853; Drosha; drosha ribonuclease III; drosha, double-stranded RNA-specific endoribonuclease; drosha, ribonuclease type III; ethanol induced 2; ETOHI2; HSA242976; MGC115770; nuclear RNase III Drosha; OTTHUMP00000220910; OTTHUMP00000220911; OTTHUMP00000220912; OTTHUMP00000220913; p241; Protein Drosha; putative protein p241 which interacts with transcription factor Sp1; putative ribonuclease III; RANSE3L; RGD1307626; ribonuclease 3; Ribonuclease III; ribonuclease III, nuclear; ribonuclease type III, nuclear; RN3; RNase III; RNASE3L; RNASEN

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
14000, 29102

Content And Storage:
-20°C

Form:
Liquid