PIMA516009
HIF1A Monoclonal Antibody (H1alpha67), DyLight™ 488, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA516009-Each-of-1 | In Stock | ₹ 48,811.98 |
PIMA516009 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,811.98
GST (18%): ₹ 8,786.156
Total Price: ₹ 57,598.136
Antigen
HIF1A
Classification
Monoclonal
Concentration
0.86 mg/mL
Formulation
50mM sodium borate with 0.05% sodium azide
Gene Accession No.
O35800, Q16665, Q61221, Q9I8A9, Q9XTA5
Gene Symbols
hif-1a, HIF1A, hif1a.L
Immunogen
Fusion protein containing amino acids 432-528 of human HIF-1alpha.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Bovine, Canine, Feline, Ferret, Human, Mouse, Non-human Primate, Ovine, Porcine, Rabbit, Rat, X. laevis
Product Type
Antibody
Isotype
IgG2b
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Western Blot
Clone
H1alpha67
Conjugate
DyLight 488
Gene
HIF1A
Gene Alias
AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; bHLHe78; Class E basic helix-loop-helix protein 78; HIF; hif 1; hif 1a; HIF1; HIF1 alpha; HIF-1 alpha; HIF1a; hif-1a; hif1a.L; HIF1alpha; HIF-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia inducible factor-1 alpha; hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1 alpha subunit; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; hypoxia-inducible factor 1-alpha; hypoxia-inducible factor-1 alpha; hypoxia-inducible factor1alpha; member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8; XELAEV_18039792mg; XELAEV_18041137mg; xhif1a
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
100009579, 100337573, 101083686, 15251, 281814, 29560, 3091, 380141, 396696, 443519, 445838, 480348
Content And Storage
4° C, store in dark
Form
Liquid
Related Products
Description
- In Western blot, multiple bands may be seen at 100-120 kDa representing post-translational modification of HIF-1 alpha
- For WB, testing on nuclear extracts is recommended
- Suggested positive control: Cos-7 nuclear extracts
- HIF1-alpha (HIF1A) is a subunit of HIF1, which is a transcription factor found in mammalian cells cultured under reduced oxygen tension
- HIF-1 is a heterodimer consisting of an alpha and beta subunit, both belonging to the basic-helix-loop-helix Per-aryl hydrocarbon receptor nuclear translocator-Sim (PAS) family of transcription factors
- HIF1 functions as a transcriptional regulator of the adaptive response to hypoxia
- Under hypoxic conditions, HIF-1 activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia
- HIF1-alpha regulates hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis
- Hypoxia which induces p53 protein accumulation, directly interacts with HIF1-alpha and reduces hypoxia-induced expression of HIF1-alpha by promoting MDM2-mediated ubiquitination and proteasomal degradation under hypoxic conditions
- Recent studies suggest that induction of NOX4 by HIF1-alpha contributes to maintain ROS levels after hypoxia and hypoxia-induced proliferation
- In humans, it is located on the q arm of chromosome 14
- The C-terminal of HIF1A binds to p300
- p300/CBP-HIF complexes participate in the induction of hypoxia-responsive genes, including VEGF
- Hypoxia contributes significantly to the pathophysiology of major categories of human disease, including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease and chronic obstructive pulmonary disease.
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Antigen: HIF1A
Classification: Monoclonal
Concentration: 0.86 mg/mL
Formulation: 50mM sodium borate with 0.05% sodium azide
Gene Accession No.: O35800, Q16665, Q61221, Q9I8A9, Q9XTA5
Gene Symbols: hif-1a, HIF1A, hif1a.L
Immunogen: Fusion protein containing amino acids 432-528 of human HIF-1alpha.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bovine, Canine, Feline, Ferret, Human, Mouse, Non-human Primate, Ovine, Porcine, Rabbit, Rat, X. laevis
Product Type: Antibody
Isotype: IgG2b
Applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Western Blot
Clone: H1alpha67
Conjugate: DyLight 488
Gene: HIF1A
Gene Alias: AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; bHLHe78; Class E basic helix-loop-helix protein 78; HIF; hif 1; hif 1a; HIF1; HIF1 alpha; HIF-1 alpha; HIF1a; hif-1a; hif1a.L; HIF1alpha; HIF-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia inducible factor-1 alpha; hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1 alpha subunit; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; hypoxia-inducible factor 1-alpha; hypoxia-inducible factor-1 alpha; hypoxia-inducible factor1alpha; member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8; XELAEV_18039792mg; XELAEV_18041137mg; xhif1a
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 100009579, 100337573, 101083686, 15251, 281814, 29560, 3091, 380141, 396696, 443519, 445838, 480348
Content And Storage: 4° C, store in dark
Form: Liquid
Antigen:
HIF1A
Classification:
Monoclonal
Concentration:
0.86 mg/mL
Formulation:
50mM sodium borate with 0.05% sodium azide
Gene Accession No.:
O35800, Q16665, Q61221, Q9I8A9, Q9XTA5
Gene Symbols:
hif-1a, HIF1A, hif1a.L
Immunogen:
Fusion protein containing amino acids 432-528 of human HIF-1alpha.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Canine, Feline, Ferret, Human, Mouse, Non-human Primate, Ovine, Porcine, Rabbit, Rat, X. laevis
Product Type:
Antibody
Isotype:
IgG2b
Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Western Blot
Clone:
H1alpha67
Conjugate:
DyLight 488
Gene:
HIF1A
Gene Alias:
AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; bHLHe78; Class E basic helix-loop-helix protein 78; HIF; hif 1; hif 1a; HIF1; HIF1 alpha; HIF-1 alpha; HIF1a; hif-1a; hif1a.L; HIF1alpha; HIF-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia inducible factor-1 alpha; hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1 alpha subunit; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; hypoxia-inducible factor 1-alpha; hypoxia-inducible factor-1 alpha; hypoxia-inducible factor1alpha; member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8; XELAEV_18039792mg; XELAEV_18041137mg; xhif1a
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
100009579, 100337573, 101083686, 15251, 281814, 29560, 3091, 380141, 396696, 443519, 445838, 480348
Content And Storage:
4° C, store in dark
Form:
Liquid
Antigen: HIF1A
Classification: Monoclonal
Concentration: 0.90 mg/mL
Formulation: 50mM sodium borate with 0.05% sodium azide
Gene Accession No.: O35800, Q16665, Q61221, Q9I8A9, Q9XTA5
Gene Symbols: hif-1a, HIF1A, hif1a.L
Immunogen: Fusion protein containing amino acids 432-528 of human HIF-1alpha.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bovine, Canine, Feline, Ferret, Human, Mouse, Non-human Primate, Ovine, Porcine, Rabbit, Rat, X. laevis
Product Type: Antibody
Isotype: IgG2b
Applications: ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone: H1alpha67
Conjugate: DyLight 550
Gene: HIF1A
Gene Alias: AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; bHLHe78; Class E basic helix-loop-helix protein 78; HIF; hif 1; hif 1a; HIF1; HIF1 alpha; HIF-1 alpha; HIF1a; hif-1a; hif1a.L; HIF1alpha; HIF-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia inducible factor-1 alpha; hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1 alpha subunit; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; hypoxia-inducible factor 1-alpha; hypoxia-inducible factor-1 alpha; hypoxia-inducible factor1alpha; member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8; XELAEV_18039792mg; XELAEV_18041137mg; xhif1a
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 100009579, 100337573, 101083686, 15251, 281814, 29560, 3091, 380141, 396696, 443519, 445838, 480348
Content And Storage: 4° C, store in dark
Form: Liquid
Antigen:
HIF1A
Classification:
Monoclonal
Concentration:
0.90 mg/mL
Formulation:
50mM sodium borate with 0.05% sodium azide
Gene Accession No.:
O35800, Q16665, Q61221, Q9I8A9, Q9XTA5
Gene Symbols:
hif-1a, HIF1A, hif1a.L
Immunogen:
Fusion protein containing amino acids 432-528 of human HIF-1alpha.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Canine, Feline, Ferret, Human, Mouse, Non-human Primate, Ovine, Porcine, Rabbit, Rat, X. laevis
Product Type:
Antibody
Isotype:
IgG2b
Applications:
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone:
H1alpha67
Conjugate:
DyLight 550
Gene:
HIF1A
Gene Alias:
AA959795; ARNT interacting protein; ARNT2; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; bHLHe78; Class E basic helix-loop-helix protein 78; HIF; hif 1; hif 1a; HIF1; HIF1 alpha; HIF-1 alpha; HIF1a; hif-1a; hif1a.L; HIF1alpha; HIF-1alpha; HIF-1-alpha; HIF1-alpha; HIF1-alpha protein; hypoxia inducible factor 1 alpha; hypoxia inducible factor 1 alpha subunit; hypoxia inducible factor 1 alpha subunit L homeolog; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1 subunit alpha L homeolog; hypoxia inducible factor 1, alpha subunit; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia inducible factor-1 alpha; hypoxia-inducible factor 1 alpha; hypoxia-inducible factor 1 alpha isoform I.3; hypoxia-inducible factor 1 alpha subunit; hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) L homeolog; hypoxia-inducible factor 1-alpha; hypoxia-inducible factor-1 alpha; hypoxia-inducible factor1alpha; member of PAS protein 1; member of PAS superfamily 1; MOP1; PAS domain-containing protein 8; PASD8; XELAEV_18039792mg; XELAEV_18041137mg; xhif1a
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
100009579, 100337573, 101083686, 15251, 281814, 29560, 3091, 380141, 396696, 443519, 445838, 480348
Content And Storage:
4° C, store in dark
Form:
Liquid
Antigen: HIF-1 beta
Classification: Monoclonal
Concentration: 1.4 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P27540, P41739, P53762, Q9BE97
Gene Symbols: ARNT
Immunogen: Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type: Antibody
Isotype: IgG1 κ
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: H1beta234
Conjugate: Biotin
Gene: ARNT
Gene Alias: AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 11863, 25242, 281010, 405, 443285
Content And Storage: 4° C, store in dark
Form: Liquid
Antigen:
HIF-1 beta
Classification:
Monoclonal
Concentration:
1.4 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P27540, P41739, P53762, Q9BE97
Gene Symbols:
ARNT
Immunogen:
Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
H1beta234
Conjugate:
Biotin
Gene:
ARNT
Gene Alias:
AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
11863, 25242, 281010, 405, 443285
Content And Storage:
4° C, store in dark
Form:
Liquid
Antigen: HIF-1 beta
Classification: Monoclonal
Concentration: 1.4 mg/mL
Formulation: 50mM sodium borate with no preservative
Gene Accession No.: P27540, P41739, P53762, Q9BE97
Gene Symbols: ARNT
Immunogen: Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type: Antibody
Isotype: IgG1 κ
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: H1beta234
Conjugate: DyLight 650
Gene: ARNT
Gene Alias: AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 11863, 25242, 281010, 405, 443285
Content And Storage: 4° C, store in dark
Form: Liquid
Antigen:
HIF-1 beta
Classification:
Monoclonal
Concentration:
1.4 mg/mL
Formulation:
50mM sodium borate with no preservative
Gene Accession No.:
P27540, P41739, P53762, Q9BE97
Gene Symbols:
ARNT
Immunogen:
Fusion protein containing amino acids 496-789 of human HIF-1 beta.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Ferret, Human, Mouse, Non-human Primate, Ovine, Rat
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
H1beta234
Conjugate:
DyLight 650
Gene:
ARNT
Gene Alias:
AHA-1; ARNT; ARNT protein; Arnt1; ARNT1a; ARNT1b; aryl hydrocarbon receptor nuclear translocater; Aryl hydrocarbon receptor nuclear translocator; Aryl hydrocarbon receptor nuclear translocator 1; aryl hydrocarbon receptor nuclear translocator type 1a; aryl hydrocarbon receptor nuclear translocator type 1b; bHLHe2; Class E basic helix-loop-helix protein 2; D3Ertd557e; dioxin receptor, nuclear translocator; Drnt; ESTM42; hif 1; HIF1 beta; HIF-1 beta; Hif1b; HIF1BETA; HIF-1beta; HIF-1-beta; HIF1-beta; hypoxia-inducible factor 1 beta; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; mKIAA4051; TANGO; W08714; zgc:136664
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
11863, 25242, 281010, 405, 443285
Content And Storage:
4° C, store in dark
Form:
Liquid