PIMA517278
HMGB1 Monoclonal Antibody (GT348), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA517278-Each-of-1 | In Stock | ₹ 51,421.56 |
PIMA517278 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 51,421.56
GST (18%): ₹ 9,255.881
Total Price: ₹ 60,677.441
Antigen
HMGB1
Classification
Monoclonal
Concentration
0.88 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
P09429, P63158, P63159
Gene Symbols
Hmgb1
Immunogen
Recombinant fragment contains a sequence corresponding to a region within amino acids 2 and 159 of HMGB1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG2a
Applications
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone
GT348
Conjugate
Unconjugated
Gene
Hmgb1
Gene Alias
Ac2-008; amphoterin; Amphoterin antibody; DEF; DKFZp686A04236; Heparin-binding protein p30; high mobility group 1; high mobility group 1 protein; high mobility group box 1; high mobility group protein 1; High mobility group protein B1; high mobility group protein HMG1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; high-mobility-group protein; Hmg1; HMG-1; HMG3; HMG3 antibody; hmgb 1; HMGB1; hmgb-1; HMGB1 protein; hypothetical protein; non-histone protein HMG1; p30; RCJMB04_15a21; RP11-550P23.1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; unnamed protein product
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
15289, 25459, 3146
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recommended positive controls: 293T, A431, HepG2, Neuro2A, C8D30, NIH-3T3, BCL-1, Raw264.7, C2C12, PC-12, Rat2, mouse brain, rat brain
- Predicted reactivity: Mouse (100%), Rat (100%), Xenopus laevis (93%), Dog (100%), Pig (100%), Rabbit (100%), Chicken (94%), Rhesus Monkey (100%), Bovine (100%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- HMGB1 (High-mobility group box-1) protein was originally described as a nuclear non-histone DNA binding chromosomal protein
- However, recent studies indicate that damaged, necrotic cells liberate HMGB1 into the extracellular milieu where it functions as a proinflammatory cytokine
- Mouse HMGB1 is expressed as a 215 amino acid single chain polypeptide containing three domains: two tandem-linked positively charged DNA-binding domains (HMG box A, aa 9-79; and box B, aa 89-162), and a negatively charged 30 aa C-terminal acidic tail region
- Residues 28 - 44 and 180 - 185 contain a nuclear localization signal (NLS)
- The cytokine activity of HMGB1 is contained in the B box, while the A box is associated with the helix-loop-helix domain of transcription factors
- HMGB1 acts both as an inflammatory mediator that promotes monocyte migration and cytokine secretion, as well as a mediator of T cell-dendritic cell interaction
- HMGB1 is secreted and acts to transduce cellular signals through its high affinity receptor, RAGE and possibly, TLR2 and TLR4
- HMGB1 is highly conserved and ubiquitous in the nuclei and cytoplasm of nearly all cell types, is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses
- HMGB1 also act as DNA nuclear binding protein that has recently been shown to be an early trigger of sterile inflammation in animal models of trauma-hemorrhage via the activation of the Toll-like receptor 4 (TLR4) and the receptor for the advanced glycation endproducts (RAGE)
- Moreover, HMGB1 is reported that the level of HMGB1 is elevated during sterile tissue injury, infection, lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury.
Compare Similar Items
Show Difference
Antigen: HMGB1
Classification: Monoclonal
Concentration: 0.88 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P09429, P63158, P63159
Gene Symbols: Hmgb1
Immunogen: Recombinant fragment contains a sequence corresponding to a region within amino acids 2 and 159 of HMGB1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG2a
Applications: Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone: GT348
Conjugate: Unconjugated
Gene: Hmgb1
Gene Alias: Ac2-008; amphoterin; Amphoterin antibody; DEF; DKFZp686A04236; Heparin-binding protein p30; high mobility group 1; high mobility group 1 protein; high mobility group box 1; high mobility group protein 1; High mobility group protein B1; high mobility group protein HMG1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; high-mobility-group protein; Hmg1; HMG-1; HMG3; HMG3 antibody; hmgb 1; HMGB1; hmgb-1; HMGB1 protein; hypothetical protein; non-histone protein HMG1; p30; RCJMB04_15a21; RP11-550P23.1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; unnamed protein product
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 15289, 25459, 3146
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
HMGB1
Classification:
Monoclonal
Concentration:
0.88 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P09429, P63158, P63159
Gene Symbols:
Hmgb1
Immunogen:
Recombinant fragment contains a sequence corresponding to a region within amino acids 2 and 159 of HMGB1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG2a
Applications:
Immunocytochemistry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Clone:
GT348
Conjugate:
Unconjugated
Gene:
Hmgb1
Gene Alias:
Ac2-008; amphoterin; Amphoterin antibody; DEF; DKFZp686A04236; Heparin-binding protein p30; high mobility group 1; high mobility group 1 protein; high mobility group box 1; high mobility group protein 1; High mobility group protein B1; high mobility group protein HMG1; high-mobility group (nonhistone chromosomal) protein 1; high-mobility group box 1; high-mobility-group protein; Hmg1; HMG-1; HMG3; HMG3 antibody; hmgb 1; HMGB1; hmgb-1; HMGB1 protein; hypothetical protein; non-histone protein HMG1; p30; RCJMB04_15a21; RP11-550P23.1; SBP-1; Sulfoglucuronyl carbohydrate binding protein; unnamed protein product
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
15289, 25459, 3146
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: PEX19
Classification: Monoclonal
Concentration: 1.17 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P40855, Q9QYU1
Gene Symbols: PEX19
Immunogen: Recombinant fragment contains a sequence corresponding to a region within amino acids 15 and 299 of PEX19
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Rat
Product Type: Antibody
Isotype: IgG2b
Applications: Flow Cytometry, Immunocytochemistry, Western Blot
Clone: GT533
Conjugate: Unconjugated
Gene: PEX19
Gene Alias: 33 kDa housekeeping protein; D1S2223E; HK33; housekeeping gene, 33kD; OK/SW-cl.22; PBD12A; peroxin-19; Peroxisomal biogenesis factor 19; peroxisomal farnesylated protein; peroxisome biogenesis factor 19; Pex19; PMP1; PMPI; PxF; PXMP1
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 289233, 5824
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
PEX19
Classification:
Monoclonal
Concentration:
1.17 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P40855, Q9QYU1
Gene Symbols:
PEX19
Immunogen:
Recombinant fragment contains a sequence corresponding to a region within amino acids 15 and 299 of PEX19
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Rat
Product Type:
Antibody
Isotype:
IgG2b
Applications:
Flow Cytometry, Immunocytochemistry, Western Blot
Clone:
GT533
Conjugate:
Unconjugated
Gene:
PEX19
Gene Alias:
33 kDa housekeeping protein; D1S2223E; HK33; housekeeping gene, 33kD; OK/SW-cl.22; PBD12A; peroxin-19; Peroxisomal biogenesis factor 19; peroxisomal farnesylated protein; peroxisome biogenesis factor 19; Pex19; PMP1; PMPI; PxF; PXMP1
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
289233, 5824
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: ADAR
Classification: Monoclonal
Concentration: 1.0 mg/mL
Formulation: PBS with 20% glycerol and no preservative; pH 7
Gene Accession No.: P55265
Gene Symbols: Adar
Immunogen: Recombinant fragment contains a sequence corresponding to a region within amino acids 472 and 757 of ADAR1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: GT1066
Conjugate: Unconjugated
Gene: Adar
Gene Alias: 136 kDa double-stranded RNA-binding protein; ADA; Adar; ADAR1; Adar1p110; Adar1p150; Adenosine Deaminase; adenosine deaminase acting on RNA 1-A; adenosine deaminase RNA specific; adenosine deaminase, RNA specific; adenosine deaminase, RNA-specific; AGS6; AV242451; double-stranded RNA-specific adenosine deaminase; DRADA; DSH; DSRAD; dsRNA adenosine deaminase; dsRNA adeonosine deaminase; G1P1; IFI4; IFI-4; interferon-induced protein 4; interferon-inducible protein 4; K88DSRBP; LOW QUALITY PROTEIN: double-stranded RNA-specific adenosine deaminase; mZaADAR; P136; RNA adenosine deaminase 1; RNA-specific adenosine deaminase p110 form; RNA-specific adenosine deaminase p150 form
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 103
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
ADAR
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Formulation:
PBS with 20% glycerol and no preservative; pH 7
Gene Accession No.:
P55265
Gene Symbols:
Adar
Immunogen:
Recombinant fragment contains a sequence corresponding to a region within amino acids 472 and 757 of ADAR1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
GT1066
Conjugate:
Unconjugated
Gene:
Adar
Gene Alias:
136 kDa double-stranded RNA-binding protein; ADA; Adar; ADAR1; Adar1p110; Adar1p150; Adenosine Deaminase; adenosine deaminase acting on RNA 1-A; adenosine deaminase RNA specific; adenosine deaminase, RNA specific; adenosine deaminase, RNA-specific; AGS6; AV242451; double-stranded RNA-specific adenosine deaminase; DRADA; DSH; DSRAD; dsRNA adenosine deaminase; dsRNA adeonosine deaminase; G1P1; IFI4; IFI-4; interferon-induced protein 4; interferon-inducible protein 4; K88DSRBP; LOW QUALITY PROTEIN: double-stranded RNA-specific adenosine deaminase; mZaADAR; P136; RNA adenosine deaminase 1; RNA-specific adenosine deaminase p110 form; RNA-specific adenosine deaminase p150 form
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
103
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: TAGLN
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P31232, P37804, Q01995
Gene Symbols: TAGLN
Immunogen: Recombinant fragment contains a sequence corresponding to a region within amino acids 1 and 201 of Transgelin
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: GT4511
Conjugate: Unconjugated
Gene: TAGLN
Gene Alias: 22 kDa actin-binding protein; 25 kDa F-actin-binding protein; actin-associated protein p27; DKFZp686B01212; DKFZp686P11128; Protein WS3-10; similar to transgelin; Sm22; sm22 alpha; SM22A; Sm22alpha; SM22-alpha; SMCC; smooth muscle 22 protein; smooth muscle protein 22-alpha; TAGLN; TAGLN1; Transgelin; transgelin variant 2; Ws310; WS3-10
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 21345, 25123, 6876
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
TAGLN
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P31232, P37804, Q01995
Gene Symbols:
TAGLN
Immunogen:
Recombinant fragment contains a sequence corresponding to a region within amino acids 1 and 201 of Transgelin
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
GT4511
Conjugate:
Unconjugated
Gene:
TAGLN
Gene Alias:
22 kDa actin-binding protein; 25 kDa F-actin-binding protein; actin-associated protein p27; DKFZp686B01212; DKFZp686P11128; Protein WS3-10; similar to transgelin; Sm22; sm22 alpha; SM22A; Sm22alpha; SM22-alpha; SMCC; smooth muscle 22 protein; smooth muscle protein 22-alpha; TAGLN; TAGLN1; Transgelin; transgelin variant 2; Ws310; WS3-10
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
21345, 25123, 6876
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid