PIMA517285
ADAR Monoclonal Antibody (GT1066), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA517285-Each-of-1 | In Stock | ₹ 45,132.90 |
PIMA517285 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,132.90
GST (18%): ₹ 8,123.922
Total Price: ₹ 53,256.822
Antigen
ADAR
Classification
Monoclonal
Concentration
1.0 mg/mL
Formulation
PBS with 20% glycerol and no preservative; pH 7
Gene Accession No.
P55265
Gene Symbols
Adar
Immunogen
Recombinant fragment contains a sequence corresponding to a region within amino acids 472 and 757 of ADAR1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone
GT1066
Conjugate
Unconjugated
Gene
Adar
Gene Alias
136 kDa double-stranded RNA-binding protein; ADA; Adar; ADAR1; Adar1p110; Adar1p150; Adenosine Deaminase; adenosine deaminase acting on RNA 1-A; adenosine deaminase RNA specific; adenosine deaminase, RNA specific; adenosine deaminase, RNA-specific; AGS6; AV242451; double-stranded RNA-specific adenosine deaminase; DRADA; DSH; DSRAD; dsRNA adenosine deaminase; dsRNA adeonosine deaminase; G1P1; IFI4; IFI-4; interferon-induced protein 4; interferon-inducible protein 4; K88DSRBP; LOW QUALITY PROTEIN: double-stranded RNA-specific adenosine deaminase; mZaADAR; P136; RNA adenosine deaminase 1; RNA-specific adenosine deaminase p110 form; RNA-specific adenosine deaminase p150 form
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
103
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recommended positive controls: 293T, A431, HeLa, HepG2, A375
- Predicted reactivity: Mouse (80%), Rat (80%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Adenosine Deaminase RNA Specific (ADAR) catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing.This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions
- ADAR can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing)
- Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3)
- Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities
- Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1
- Its viral RNA substrates include: hepatitis C virus (HCV), vesicular stomatitis virus (VSV), measles virus (MV), hepatitis delta virus (HDV), and human immunodeficiency virus type 1 (HIV-1)
- Exhibits either a proviral (HDV, MV, VSV and HIV-1) or an antiviral effect (HCV) and this can be editing-dependent (HDV and HCV), editing-independent (VSV and MV) or both (HIV-1)
- Impairs HCV replication via RNA editing at multiple sites
- Enhances the replication of MV, VSV and HIV-1 through an editing-independent mechanism via suppression of EIF2AK2/PKR activation and function
- Stimulates both the release and infectivity of HIV-1 viral particles by an editing-dependent mechanism where it associates with viral RNAs and edits adenosines in the 5'UTR and the Rev and Tat coding sequence
- Can enhance viral replication of HDV via A-to-I editing at a site designated as amber/W, thereby changing an UAG amber stop codon to an UIG tryptophan (W) codon that permits synthesis of the large delta antigen (L-HDAg) which has a key role in the assembly of viral particles
- However, high levels of ADAR1 inhibit HDV replication
- (Uniprot)
Compare Similar Items
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Antigen: ADAR
Classification: Monoclonal
Concentration: 1.0 mg/mL
Formulation: PBS with 20% glycerol and no preservative; pH 7
Gene Accession No.: P55265
Gene Symbols: Adar
Immunogen: Recombinant fragment contains a sequence corresponding to a region within amino acids 472 and 757 of ADAR1
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: GT1066
Conjugate: Unconjugated
Gene: Adar
Gene Alias: 136 kDa double-stranded RNA-binding protein; ADA; Adar; ADAR1; Adar1p110; Adar1p150; Adenosine Deaminase; adenosine deaminase acting on RNA 1-A; adenosine deaminase RNA specific; adenosine deaminase, RNA specific; adenosine deaminase, RNA-specific; AGS6; AV242451; double-stranded RNA-specific adenosine deaminase; DRADA; DSH; DSRAD; dsRNA adenosine deaminase; dsRNA adeonosine deaminase; G1P1; IFI4; IFI-4; interferon-induced protein 4; interferon-inducible protein 4; K88DSRBP; LOW QUALITY PROTEIN: double-stranded RNA-specific adenosine deaminase; mZaADAR; P136; RNA adenosine deaminase 1; RNA-specific adenosine deaminase p110 form; RNA-specific adenosine deaminase p150 form
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 103
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
ADAR
Classification:
Monoclonal
Concentration:
1.0 mg/mL
Formulation:
PBS with 20% glycerol and no preservative; pH 7
Gene Accession No.:
P55265
Gene Symbols:
Adar
Immunogen:
Recombinant fragment contains a sequence corresponding to a region within amino acids 472 and 757 of ADAR1
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
GT1066
Conjugate:
Unconjugated
Gene:
Adar
Gene Alias:
136 kDa double-stranded RNA-binding protein; ADA; Adar; ADAR1; Adar1p110; Adar1p150; Adenosine Deaminase; adenosine deaminase acting on RNA 1-A; adenosine deaminase RNA specific; adenosine deaminase, RNA specific; adenosine deaminase, RNA-specific; AGS6; AV242451; double-stranded RNA-specific adenosine deaminase; DRADA; DSH; DSRAD; dsRNA adenosine deaminase; dsRNA adeonosine deaminase; G1P1; IFI4; IFI-4; interferon-induced protein 4; interferon-inducible protein 4; K88DSRBP; LOW QUALITY PROTEIN: double-stranded RNA-specific adenosine deaminase; mZaADAR; P136; RNA adenosine deaminase 1; RNA-specific adenosine deaminase p110 form; RNA-specific adenosine deaminase p150 form
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
103
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: TAGLN
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P31232, P37804, Q01995
Gene Symbols: TAGLN
Immunogen: Recombinant fragment contains a sequence corresponding to a region within amino acids 1 and 201 of Transgelin
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: GT4511
Conjugate: Unconjugated
Gene: TAGLN
Gene Alias: 22 kDa actin-binding protein; 25 kDa F-actin-binding protein; actin-associated protein p27; DKFZp686B01212; DKFZp686P11128; Protein WS3-10; similar to transgelin; Sm22; sm22 alpha; SM22A; Sm22alpha; SM22-alpha; SMCC; smooth muscle 22 protein; smooth muscle protein 22-alpha; TAGLN; TAGLN1; Transgelin; transgelin variant 2; Ws310; WS3-10
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 21345, 25123, 6876
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
TAGLN
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P31232, P37804, Q01995
Gene Symbols:
TAGLN
Immunogen:
Recombinant fragment contains a sequence corresponding to a region within amino acids 1 and 201 of Transgelin
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
GT4511
Conjugate:
Unconjugated
Gene:
TAGLN
Gene Alias:
22 kDa actin-binding protein; 25 kDa F-actin-binding protein; actin-associated protein p27; DKFZp686B01212; DKFZp686P11128; Protein WS3-10; similar to transgelin; Sm22; sm22 alpha; SM22A; Sm22alpha; SM22-alpha; SMCC; smooth muscle 22 protein; smooth muscle protein 22-alpha; TAGLN; TAGLN1; Transgelin; transgelin variant 2; Ws310; WS3-10
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
21345, 25123, 6876
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: PAF49
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: O15446
Gene Symbols: Cd3eap
Immunogen: Synthetic peptide contains a sequence corresponding to a region within amino acids 1 and 95 of PAF49
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2b
Applications: Immunocytochemistry, Western Blot
Clone: GT1964
Conjugate: Unconjugated
Gene: Cd3eap
Gene Alias: 1190028F09; 2610103M17Rik; A34.5; antis; Anti-sense to ERCC-1 protein; antisense to ERCC-1 protein; Ase1; ASE-1; CAST; CD3 epsilon associated protein; antisense to Ercc1; CD3E antigen, epsilon polypeptide associated protein; CD3E antigen, epsilon polypeptide-associated protein; CD3e molecule associated protein; CD3e molecule, epsilon associated protein; Cd3eap; CD3E-associated protein; CD3-epsilon-associated protein; DNA-directed RNA polymerase I subunit RPA34; PAF49; RGD1305916; RNA polymerase I-associated factor PAF49
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 10849
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
PAF49
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
O15446
Gene Symbols:
Cd3eap
Immunogen:
Synthetic peptide contains a sequence corresponding to a region within amino acids 1 and 95 of PAF49
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2b
Applications:
Immunocytochemistry, Western Blot
Clone:
GT1964
Conjugate:
Unconjugated
Gene:
Cd3eap
Gene Alias:
1190028F09; 2610103M17Rik; A34.5; antis; Anti-sense to ERCC-1 protein; antisense to ERCC-1 protein; Ase1; ASE-1; CAST; CD3 epsilon associated protein; antisense to Ercc1; CD3E antigen, epsilon polypeptide associated protein; CD3E antigen, epsilon polypeptide-associated protein; CD3e molecule associated protein; CD3e molecule, epsilon associated protein; Cd3eap; CD3E-associated protein; CD3-epsilon-associated protein; DNA-directed RNA polymerase I subunit RPA34; PAF49; RGD1305916; RNA polymerase I-associated factor PAF49
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
10849
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: Dengue Virus Type 2 Envelope
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: __
Gene Symbols: __
Immunogen: Recombinant fragment contains a sequence corresponding to a region within amino acids 1 and 276 of Envelope protein (Dengue virus 2)
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Virus
Product Type: Antibody
Isotype: IgG2a
Applications: Immunocytochemistry, Western Blot
Clone: GT214
Conjugate: Unconjugated
Gene: __
Gene Alias: Dengue 2 envelope; Dengue envelope; envelope protein
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Dengue Virus Type 2 Envelope
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
__
Gene Symbols:
__
Immunogen:
Recombinant fragment contains a sequence corresponding to a region within amino acids 1 and 276 of Envelope protein (Dengue virus 2)
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Virus
Product Type:
Antibody
Isotype:
IgG2a
Applications:
Immunocytochemistry, Western Blot
Clone:
GT214
Conjugate:
Unconjugated
Gene:
__
Gene Alias:
Dengue 2 envelope; Dengue envelope; envelope protein
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
__
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid