PIMA524888
ICAD Monoclonal Antibody (OTI1B10), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA524888-Each-of-1 | In Stock | ₹ 50,180.94 |
PIMA524888 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,180.94
GST (18%): ₹ 9,032.569
Total Price: ₹ 59,213.509
Antigen
ICAD
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
O00273
Gene Symbols
DFFA
Immunogen
Recombinant protein expressed in E.coli corresponding to amino acids 1-331 of DFF45.
Quantity
100μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Western Blot
Clone
OTI1B10
Conjugate
Unconjugated
Gene
DFFA
Gene Alias
A330085O09Rik; DFF; DFF1; DFF35; Dff45; DFF-45; Dffa; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; H13; ICAD; ICAD-L; ICAD-S; Inhibitor of CAD; RP23-121D17.3
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
1676
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- ICAD is the inhibitor of caspase-3-activated DNase which is a substrate that controls nuclear apoptosis
- ICAD has two isoforms: a functional isoform of 45kDa, ICAD-L/DNA fragmentation factor (DFF) 45; and a 35kDa isoform, ICAD-S/DFF35
- Although both ICAD-L and ICAD-S can bind and inhibit CAD, only ICAD-L was reported to be functional
- ICAD is cleaved to be inactivated and allow caspase-activated DNase (CAD) to execute nuclear internucleosomal apoptotic DNA fragmentation
- In non-apoptotic cells, CAD is complexed with its inhibitor, ICAD
- The activation of the CAD/ICAD complex occurs through the caspase 3-mediated cleavage of ICAD at residues 117 and 224, which results in three ICAD fragments that are then released from CAD
- In addition to its DNase inhibitory activity, ICAD acts as a CAD specific folding chaperone
- There are recent reports that ICAD is a potential target for restoring a normal apoptotic signal transduction pathway in colon and brain cancer cells
- Two alternatively spliced transcript variants encoding distinct isoforms have been found for the ICAD gene.
Compare Similar Items
Show Difference
Antigen: ICAD
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: O00273
Gene Symbols: DFFA
Immunogen: Recombinant protein expressed in E.coli corresponding to amino acids 1-331 of DFF45.
Quantity: 100μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Western Blot
Clone: OTI1B10
Conjugate: Unconjugated
Gene: DFFA
Gene Alias: A330085O09Rik; DFF; DFF1; DFF35; Dff45; DFF-45; Dffa; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; H13; ICAD; ICAD-L; ICAD-S; Inhibitor of CAD; RP23-121D17.3
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 1676
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
ICAD
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
O00273
Gene Symbols:
DFFA
Immunogen:
Recombinant protein expressed in E.coli corresponding to amino acids 1-331 of DFF45.
Quantity:
100μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Western Blot
Clone:
OTI1B10
Conjugate:
Unconjugated
Gene:
DFFA
Gene Alias:
A330085O09Rik; DFF; DFF1; DFF35; Dff45; DFF-45; Dffa; DNA fragmentation factor 45 kDa subunit; DNA fragmentation factor subunit alpha; DNA fragmentation factor, 45kDa, alpha polypeptide; DNA fragmentation factor, alpha subunit; H13; ICAD; ICAD-L; ICAD-S; Inhibitor of CAD; RP23-121D17.3
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
1676
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: GSC
Classification: Monoclonal
Concentration: 0.19 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: P56915
Gene Symbols: GSC
Immunogen: Recombinant fragment expressed in E.coli corresponding to amino acids 107-257 of goosecoid.
Quantity: 100μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2a
Applications: Immunocytochemistry
Clone: OTI4F11
Conjugate: Unconjugated
Gene: GSC
Gene Alias: GCS; goosecoid; goosecoid homeobox; goosecoid protein; GSC; Homeobox protein goosecoid; SAMS
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 145258
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
GSC
Classification:
Monoclonal
Concentration:
0.19 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
P56915
Gene Symbols:
GSC
Immunogen:
Recombinant fragment expressed in E.coli corresponding to amino acids 107-257 of goosecoid.
Quantity:
100μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2a
Applications:
Immunocytochemistry
Clone:
OTI4F11
Conjugate:
Unconjugated
Gene:
GSC
Gene Alias:
GCS; goosecoid; goosecoid homeobox; goosecoid protein; GSC; Homeobox protein goosecoid; SAMS
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
145258
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: NeuroG3
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q9Y4Z2
Gene Symbols: NEUROG3
Immunogen: Recombinant fragment expressed in E.coli corresponding to amino acids 1-214 of Ngn3.
Quantity: 100μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2b
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: OTI5A8
Conjugate: Unconjugated
Gene: NEUROG3
Gene Alias: ATH4B; Atoh5; atonal homolog 5; BHLHA7; Class A basic helix-loop-helix protein 7; helix-loop-helix protein mATH-4B; LOW QUALITY PROTEIN: neurogenin-3; Math4B; Neurog3; neurogenin 3; Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B); neurogenin3; neurogenin-3; ngn3; NGN-3; Protein atonal homolog 5; Relax; transcriptional regulator, Relax
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 50674
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
NeuroG3
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q9Y4Z2
Gene Symbols:
NEUROG3
Immunogen:
Recombinant fragment expressed in E.coli corresponding to amino acids 1-214 of Ngn3.
Quantity:
100μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG2b
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI5A8
Conjugate:
Unconjugated
Gene:
NEUROG3
Gene Alias:
ATH4B; Atoh5; atonal homolog 5; BHLHA7; Class A basic helix-loop-helix protein 7; helix-loop-helix protein mATH-4B; LOW QUALITY PROTEIN: neurogenin-3; Math4B; Neurog3; neurogenin 3; Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B); neurogenin3; neurogenin-3; ngn3; NGN-3; Protein atonal homolog 5; Relax; transcriptional regulator, Relax
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
50674
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: SOX17
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q9H6I2
Gene Symbols: SOX17
Immunogen: Human recombinant protein fragment corresponding to amino acids 177-414 of SOX17 produced in E.coli
Quantity: 100μL
Primary or Secondary: Primary
Target Species: Canine, Human
Product Type: Antibody
Isotype: IgG2b
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: OTI2G8
Conjugate: Unconjugated
Gene: SOX17
Gene Alias: HMG transcription factor SOX17; HMG-box transcription factor Sox17; Sox17; Sox-17; SRY (sex determining region Y)-box 17; SRY box 17; SRY-box 17; SRY-box containing gene 17; SRY-box transcription factor 17; SRY-related HMG-box transcription factor SOX17; transcription factor SOX-17; transcription factor SOX-17; LOW QUALITY PROTEIN: transcription factor SOX-17; VUR3
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 486955, 64321
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
SOX17
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q9H6I2
Gene Symbols:
SOX17
Immunogen:
Human recombinant protein fragment corresponding to amino acids 177-414 of SOX17 produced in E.coli
Quantity:
100μL
Primary or Secondary:
Primary
Target Species:
Canine, Human
Product Type:
Antibody
Isotype:
IgG2b
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI2G8
Conjugate:
Unconjugated
Gene:
SOX17
Gene Alias:
HMG transcription factor SOX17; HMG-box transcription factor Sox17; Sox17; Sox-17; SRY (sex determining region Y)-box 17; SRY box 17; SRY-box 17; SRY-box containing gene 17; SRY-box transcription factor 17; SRY-related HMG-box transcription factor SOX17; transcription factor SOX-17; transcription factor SOX-17; LOW QUALITY PROTEIN: transcription factor SOX-17; VUR3
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
486955, 64321
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid