PIMA527121
FXR Monoclonal Antibody (OTI4F12), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA527121-Each-of-1 | In Stock | ₹ 50,180.94 |
PIMA527121 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,180.94
GST (18%): ₹ 9,032.569
Total Price: ₹ 59,213.509
Antigen
FXR
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q96RI1
Gene Symbols
NR1H4
Immunogen
Human recombinant protein fragment corresponding to amino acids 21-297 of NR1H4 produced in E.coli
Quantity
100μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
OTI4F12
Conjugate
Unconjugated
Gene
NR1H4
Gene Alias
AI957360; BAR; bile acid receptor; farnesoid X activated receptor; farnesoid X nuclear receptor; farnesoid X-activated receptor; Farnesol receptor HRR-1; FXR; HRR1; HRR-1; hypothetical protein LOC540528; MGC163445; NR1H4; Nuclear receptor subfamily 1 group H member 4; nuclear receptor subfamily 1, group H, member 4; retinoid X receptor-interacting protein 14; RIP14; RXR-interacting protein 14; Rxrip14
Host Species
Mouse
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
9971
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- FXR (farnesoid X receptor; NR1H4) belongs to nuclear receptor superfamily of ligand-activated transcription factors (NR1 subfamily) and acts as a receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid
- FXR plays an essential role in bile acid homeostasis through the regulation of genes involved in bile acid synthesis, conjugation and enterohepatic circulation
- FXR also regulates lipid and glucose homeostasis and is involved innate immune response
- The FXR-RXR heterodimer binds predominantly to farnesoid X receptor response elements (FXREs) containing two inverted repeats of the consensus sequence 5'-AGGTCA-3' in which the monomers are spaced by 1 nucleotide (IR-1) but also to tandem repeat DR1 sites with lower affinity, and can be activated by either FXR or RXR-specific ligands
- In the liver FXR activates transcription of the corepressor NR0B2 thereby indirectly inhibiting CYP7A1 and CYP8B1 (involved in BA synthesis) implicating at least in part histone demethylase KDM1A resulting in epigenomic repression, and SLC10A1/NTCP (involved in hepatic uptake of conjugated BAs)
- FXR activates transcription of SLC27A5/BACS and BAAT (involved in BA conjugation), ABCB11/BSEP (involved in bile salt export) by directly recruiting histone methyltransferase CARM1, and ABCC2/MRP2 (involved in secretion of conjugated BAs) and ABCB4 (involved in secretion of phosphatidylcholine in the small intestine)
- (From Uniprot)
Compare Similar Items
Show Difference
Antigen: FXR
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q96RI1
Gene Symbols: NR1H4
Immunogen: Human recombinant protein fragment corresponding to amino acids 21-297 of NR1H4 produced in E.coli
Quantity: 100μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: OTI4F12
Conjugate: Unconjugated
Gene: NR1H4
Gene Alias: AI957360; BAR; bile acid receptor; farnesoid X activated receptor; farnesoid X nuclear receptor; farnesoid X-activated receptor; Farnesol receptor HRR-1; FXR; HRR1; HRR-1; hypothetical protein LOC540528; MGC163445; NR1H4; Nuclear receptor subfamily 1 group H member 4; nuclear receptor subfamily 1, group H, member 4; retinoid X receptor-interacting protein 14; RIP14; RXR-interacting protein 14; Rxrip14
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 9971
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
FXR
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q96RI1
Gene Symbols:
NR1H4
Immunogen:
Human recombinant protein fragment corresponding to amino acids 21-297 of NR1H4 produced in E.coli
Quantity:
100μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
OTI4F12
Conjugate:
Unconjugated
Gene:
NR1H4
Gene Alias:
AI957360; BAR; bile acid receptor; farnesoid X activated receptor; farnesoid X nuclear receptor; farnesoid X-activated receptor; Farnesol receptor HRR-1; FXR; HRR1; HRR-1; hypothetical protein LOC540528; MGC163445; NR1H4; Nuclear receptor subfamily 1 group H member 4; nuclear receptor subfamily 1, group H, member 4; retinoid X receptor-interacting protein 14; RIP14; RXR-interacting protein 14; Rxrip14
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9971
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: GEF-H1
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q92974
Gene Symbols: ARHGEF2
Immunogen: Full length human recombinant protein of ARHGEF2 produced in HEK293T cell
Quantity: 100μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Western Blot
Clone: OTI5F2
Conjugate: Unconjugated
Gene: ARHGEF2
Gene Alias: AA408978; ARHGEF2; CG10188; CG10188-PA; CG10188-PB; CG10188-PC; cyst; cyst-PA; cyst-PB; cyst-PC; cysts; DKFZp547L106; DKFZp547P1516; Dmel\CG10188; Dmel_CG10188; FLJ45440; GEF; GEFH1; GEF-H1; Guanine nucleotide exchange factor H1; Kiaa0651; Lbcl1; LBC'S first cousin; Lfc; LFP40; Lymphoid blast crisis-like 1; microtubule-regulated Rho-GEF; mKIAA0651; oncogene LFC; OTTHUMP00000018855; P40; Proliferating cell nucleolar antigen p40; rho guanine nucleotide exchange factor 2; rho guanine nucleotide exchange factor 2-like protein; Rho/Rac guanine nucleotide exchange factor (GEF) 2; Rho/Rac guanine nucleotide exchange factor 2; rhobin
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 9181
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
GEF-H1
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q92974
Gene Symbols:
ARHGEF2
Immunogen:
Full length human recombinant protein of ARHGEF2 produced in HEK293T cell
Quantity:
100μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Western Blot
Clone:
OTI5F2
Conjugate:
Unconjugated
Gene:
ARHGEF2
Gene Alias:
AA408978; ARHGEF2; CG10188; CG10188-PA; CG10188-PB; CG10188-PC; cyst; cyst-PA; cyst-PB; cyst-PC; cysts; DKFZp547L106; DKFZp547P1516; Dmel\CG10188; Dmel_CG10188; FLJ45440; GEF; GEFH1; GEF-H1; Guanine nucleotide exchange factor H1; Kiaa0651; Lbcl1; LBC'S first cousin; Lfc; LFP40; Lymphoid blast crisis-like 1; microtubule-regulated Rho-GEF; mKIAA0651; oncogene LFC; OTTHUMP00000018855; P40; Proliferating cell nucleolar antigen p40; rho guanine nucleotide exchange factor 2; rho guanine nucleotide exchange factor 2-like protein; Rho/Rac guanine nucleotide exchange factor (GEF) 2; Rho/Rac guanine nucleotide exchange factor 2; rhobin
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9181
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: TCEANC2
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q96MN5
Gene Symbols: Tceanc2
Immunogen: Full length human recombinant protein of TCEANC2 produced in E.coli
Quantity: 100μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Western Blot
Clone: OTI2D2
Conjugate: Unconjugated
Gene: Tceanc2
Gene Alias: 2210010B22Rik; 2210012G02Rik; 6330404A07Rik; AU015593; C1orf83; TCEANC2; Tdeanc2; transcription elongation factor A (SII) N-terminal and central domain containing 2; transcription elongation factor A N-terminal and central domain containing 2; transcription elongation factor A N-terminal and central domain-containing protein 2
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 127428
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
TCEANC2
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q96MN5
Gene Symbols:
Tceanc2
Immunogen:
Full length human recombinant protein of TCEANC2 produced in E.coli
Quantity:
100μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Western Blot
Clone:
OTI2D2
Conjugate:
Unconjugated
Gene:
Tceanc2
Gene Alias:
2210010B22Rik; 2210012G02Rik; 6330404A07Rik; AU015593; C1orf83; TCEANC2; Tdeanc2; transcription elongation factor A (SII) N-terminal and central domain containing 2; transcription elongation factor A N-terminal and central domain containing 2; transcription elongation factor A N-terminal and central domain-containing protein 2
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
127428
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: MED27
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.: Q6P2C8
Gene Symbols: MED27
Immunogen: Human recombinant protein fragment corresponding to amino acids 24-247 of MED27 produced in E.coli
Quantity: 100μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Western Blot
Clone: OTI2A4
Conjugate: Unconjugated
Gene: MED27
Gene Alias: 1500015J03Rik; 2310042P07Rik; AA682045; cofactor required for Sp1 transcriptional activation subunit 8; cofactor required for Sp1 transcriptional activation, subunit 8; cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa; CRAP34; CRSP complex subunit 8; CRSP34; CRSP8; D2Ertd434e; LOC525389 protein; MED27; MED3; mediator complex subunit 27; Mediator of RNA polymerase II transcription subunit 27; MGC11274; p37 TRAP/SMCC/PC2 subunit; RGD1564993; transcriptional coactivator CRSP34; transcriptional co-activator CRSP8 homolog; TRAP37
Host Species: Mouse
Purification Method: Affinity Chromatography
Regulatory Status: RUO
Gene ID (Entrez): 9442
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
MED27
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.:
Q6P2C8
Gene Symbols:
MED27
Immunogen:
Human recombinant protein fragment corresponding to amino acids 24-247 of MED27 produced in E.coli
Quantity:
100μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1
Applications:
Western Blot
Clone:
OTI2A4
Conjugate:
Unconjugated
Gene:
MED27
Gene Alias:
1500015J03Rik; 2310042P07Rik; AA682045; cofactor required for Sp1 transcriptional activation subunit 8; cofactor required for Sp1 transcriptional activation, subunit 8; cofactor required for Sp1 transcriptional activation, subunit 8, 34kDa; CRAP34; CRSP complex subunit 8; CRSP34; CRSP8; D2Ertd434e; LOC525389 protein; MED27; MED3; mediator complex subunit 27; Mediator of RNA polymerase II transcription subunit 27; MGC11274; p37 TRAP/SMCC/PC2 subunit; RGD1564993; transcriptional coactivator CRSP34; transcriptional co-activator CRSP8 homolog; TRAP37
Host Species:
Mouse
Purification Method:
Affinity Chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
9442
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid