SHANK3 Monoclonal Antibody (S367-51), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA527602-Each-of-1 | In Stock | ₹ 50,266.50 |
PIMA527602 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,266.50
GST (18%): ₹ 9,047.97
Total Price: ₹ 59,314.47
Antigen
SHANK3
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
Gene Accession No.
Q4ACU6, Q9BYB0, Q9JLU4
Gene Symbols
Shank3
Immunogen
Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3. Mouse: 100% identity (89/89 amino acids identical). Human: 97% identity (87/89 amino acids identical). ∽70% identity with SHANK1 and SHANK2.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG2a
Applications
Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
Clone
S367-51
Conjugate
Unconjugated
Gene
Shank3
Gene Alias
AI841104; DEL22q13.3; Kiaa1650; proline rich synapse associated protein 2; proline-rich synapse-associated protein 2; PROSAP2; PSAP2; SCZD15; SH3 and multiple ankyrin repeat domains 3; SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains protein 3 variant c-3; SH3 and multiple ankyrin repeat domains protein 3 variant c-4; SH3 and multiple ankyrin repeat domains-like protein 3 variant 1; SH3 and multiple ankyrin repeat domains-like protein 3 variant 2; SH3 and multiple ankyrin repeat domains-like protein 3 variant 3; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-3; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-2; SH3/ankyrin domain gene 3; shank postsynaptic density protein; Shank postsynaptic density protein 3a; SHANK3; shank3 splice variant II; shank3 splice variant III; shank3 splice variant IV; Shank3b; SHANK3c-3; SHANK3c-4; shank3e splice variant III; shank3e splice variant IV; SPANK 2; SPANK2; SPANK-2
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
58234, 59312, 85358
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- 1 μg/mL of MA5-27602 was sufficient for detection of SHANK1/SHANK3 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.∣Detects approximately 190kDa
- Cross-reacts with SHANK1
- Does not cross-react with SHANK2
- SHANK3 is a major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance
- It interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton
- SHANK3 plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters
- By way of this control of actin dynamics, SHANK3 participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling
- It also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity
- SHANK3 may be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation
- (Uniprot)
Compare Similar Items
Show Difference
Antigen: SHANK3
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
Gene Accession No.: Q4ACU6, Q9BYB0, Q9JLU4
Gene Symbols: Shank3
Immunogen: Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3. Mouse: 100% identity (89/89 amino acids identical). Human: 97% identity (87/89 amino acids identical). ∽70% identity with SHANK1 and SHANK2.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG2a
Applications: Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
Clone: S367-51
Conjugate: Unconjugated
Gene: Shank3
Gene Alias: AI841104; DEL22q13.3; Kiaa1650; proline rich synapse associated protein 2; proline-rich synapse-associated protein 2; PROSAP2; PSAP2; SCZD15; SH3 and multiple ankyrin repeat domains 3; SH3 and multiple ankyrin repeat domains protein 3; SH3 and multiple ankyrin repeat domains protein 3 variant c-3; SH3 and multiple ankyrin repeat domains protein 3 variant c-4; SH3 and multiple ankyrin repeat domains-like protein 3 variant 1; SH3 and multiple ankyrin repeat domains-like protein 3 variant 2; SH3 and multiple ankyrin repeat domains-like protein 3 variant 3; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant c-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-2; SH3 and multiple ankyrin repeat domains-like protein 3 variant d-3; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-1; SH3 and multiple ankyrin repeat domains-like protein 3 variant e-2; SH3/ankyrin domain gene 3; shank postsynaptic density protein; Shank postsynaptic density protein 3a; SHANK3; shank3 splice variant II; shank3 splice variant III; shank3 splice variant IV; Shank3b; SHANK3c-3; SHANK3c-4; shank3e splice variant III; shank3e splice variant IV; SPANK 2; SPANK2; SPANK-2
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 58234, 59312, 85358
Content And Storage: -20°C
Form: Liquid
Antigen: ATAD1
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.09% sodium azide; pH 7.4
Gene Accession No.: Q505J9, Q8NBU5, Q9D5T0
Gene Symbols: ATAD1
Immunogen: Fusion protein amino acids 1-361 (Full length) of mouse Thorase
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: S125-10
Conjugate: Unconjugated
Gene: ATAD1
Gene Alias: 4921525H23Rik; AAA+ ATPase Thorase; Ab2-088; AFDC1; Atad1; ATPase family AAA domain containing 1; ATPase family AAA domain-containing protein 1; ATPase family, AAA domain containing 1; ATPase Thorase; AW107648; FLJ14600; FNP001; neuroprotective protein 6; Npg6; Thorase
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 309532, 67979, 84896
Content And Storage: -20°C
Form: Liquid
Antigen: Spectrin beta-4
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.4
Gene Accession No.: Q9H254
Gene Symbols: SPTBN4
Immunogen: Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
Clone: S393-2
Conjugate: Unconjugated
Gene: SPTBN4
Gene Alias: 1700022P15Rik; 5830426A08Rik; beta-IV spectrin; beta-spectrin 4; dyn; EMBL BAB83243.1; KIAA1642; lnd; lumbosacral neuroaxonal dystrophy; neuroaxonal dystrophy; nmf261; nmf379; quivering; qv; ROSA62; SpbIV; spectrin beta 4; spectrin beta chain, brain 3; spectrin beta chain, non-erythrocytic 4; spectrin beta, non-erythrocytic 4; spectrin, beta, non-erythrocytic 4; spectrin, non-erythroid beta chain 3; SPNB4; SPTBN3; SPTBN4
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 308458, 57731, 80297
Content And Storage: -20°C
Form: Liquid
