PIMA528581
CD206 (MMR) Monoclonal Antibody (15-2), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA528581-Each-of-1 | In Stock | ₹ 17,368.68 |
PIMA528581 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 17,368.68
GST (18%): ₹ 3,126.362
Total Price: ₹ 20,495.042
Antigen
CD206 (MMR)
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative; pH 7.4
Gene Accession No.
P22897
Gene Symbols
Mrc1
Immunogen
Purified human mannose receptor
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1 κ
Applications
Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Clone
15-2
Conjugate
Unconjugated
Gene
Mrc1
Gene Alias
AW259686; bA541I19.1; CD206; CELE_Y39A3CR.4; CLEC13D; CLEC13DL; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; ddp-1; hMR; Human mannose receptor; macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; Mitochondrial import inner membrane translocase subunit Tim8; MMR; MR; MRC1; MRC1L1; tim-8; Y39A3CR.4
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
4360
Content And Storage
4° C, do not freeze
Form
Liquid
Related Products
Description
- The mouse monoclonal antibody 15-2 (also known as MR15-2) recognizes CD206 (macrophage mannose receptor, MMR), a 162-175 kDa type I transmembrane protein expressed mainly on macrophages, dendritic cells and hepatic or lymphatic endothelial cells, but not on monocytes
- Low endotoxin azide free phosphate buffered saline (PBS) solution, 0.2 μm filter sterilized
- Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test
- Functional Application: Blocking
- CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors
- CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells
- CD206 is thought to play a role in the innate and adaptive immune response
- CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons
- CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta)
- While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD)
- CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing
- The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs)
- The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms
- CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis
- The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages
- Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.
Compare Similar Items
Show Difference
Antigen: CD206 (MMR)
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative; pH 7.4
Gene Accession No.: P22897
Gene Symbols: Mrc1
Immunogen: Purified human mannose receptor
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1 κ
Applications: Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Clone: 15-2
Conjugate: Unconjugated
Gene: Mrc1
Gene Alias: AW259686; bA541I19.1; CD206; CELE_Y39A3CR.4; CLEC13D; CLEC13DL; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; ddp-1; hMR; Human mannose receptor; macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; Mitochondrial import inner membrane translocase subunit Tim8; MMR; MR; MRC1; MRC1L1; tim-8; Y39A3CR.4
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 4360
Content And Storage: 4° C, do not freeze
Form: Liquid
Antigen:
CD206 (MMR)
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative; pH 7.4
Gene Accession No.:
P22897
Gene Symbols:
Mrc1
Immunogen:
Purified human mannose receptor
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry (Frozen), Immunoprecipitation, Western Blot
Clone:
15-2
Conjugate:
Unconjugated
Gene:
Mrc1
Gene Alias:
AW259686; bA541I19.1; CD206; CELE_Y39A3CR.4; CLEC13D; CLEC13DL; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; ddp-1; hMR; Human mannose receptor; macrophage mannose receptor 1; Macrophage mannose receptor 1-like protein 1; mannose receptor, C type 1; mannose receptor, C type 1-like 1; Mitochondrial import inner membrane translocase subunit Tim8; MMR; MR; MRC1; MRC1L1; tim-8; Y39A3CR.4
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
4360
Content And Storage:
4° C, do not freeze
Form:
Liquid
Antigen: CD279 (PD-1)
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative; pH 7.4
Gene Accession No.: Q15116
Gene Symbols: Pdcd1
Immunogen: Recombinant human CD279
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Chimpanzee, Cynomolgus Monkey, Human, Non-human Primate, Rhesus Monkey
Product Type: Antibody
Isotype: IgG1 κ
Applications: Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Clone: EH12.2H7
Conjugate: Unconjugated
Gene: Pdcd1
Gene Alias: CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 100135775, 100400173, 101044440, 102123659, 5133, 748796
Content And Storage: 4° C, do not freeze
Form: Liquid
Antigen:
CD279 (PD-1)
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative; pH 7.4
Gene Accession No.:
Q15116
Gene Symbols:
Pdcd1
Immunogen:
Recombinant human CD279
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Chimpanzee, Cynomolgus Monkey, Human, Non-human Primate, Rhesus Monkey
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Flow Cytometry, Functional Assay, Immunohistochemistry (Frozen)
Clone:
EH12.2H7
Conjugate:
Unconjugated
Gene:
Pdcd1
Gene Alias:
CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
100135775, 100400173, 101044440, 102123659, 5133, 748796
Content And Storage:
4° C, do not freeze
Form:
Liquid
Antigen: CD279 (PD-1)
Classification: Monoclonal
Concentration: __
Formulation: PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene Accession No.: Q15116
Gene Symbols: Pdcd1
Immunogen: The exact immunogen is proprietary
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Chimpanzee, Cynomolgus Monkey, Human, Non-human Primate, Rhesus Monkey
Product Type: Antibody
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: EH12.2H7
Conjugate: PE
Gene: Pdcd1
Gene Alias: CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Host Species: Mouse
Purification Method: Size-exclusion chromatography
Regulatory Status: RUO
Gene ID (Entrez): 100135775, 100400173, 101044440, 102123659, 5133, 748796
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Antigen:
CD279 (PD-1)
Classification:
Monoclonal
Concentration:
__
Formulation:
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene Accession No.:
Q15116
Gene Symbols:
Pdcd1
Immunogen:
The exact immunogen is proprietary
Quantity:
100 Tests
Primary or Secondary:
Primary
Target Species:
Chimpanzee, Cynomolgus Monkey, Human, Non-human Primate, Rhesus Monkey
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
EH12.2H7
Conjugate:
PE
Gene:
Pdcd1
Gene Alias:
CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Host Species:
Mouse
Purification Method:
Size-exclusion chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
100135775, 100400173, 101044440, 102123659, 5133, 748796
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Antigen: CD279 (PD-1)
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 15mM sodium azide; pH 7.4
Gene Accession No.: Q15116
Gene Symbols: Pdcd1
Immunogen: The exact immunogen is proprietary
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Chimpanzee, Cynomolgus Monkey, Human, Non-human Primate, Rhesus Monkey
Product Type: Antibody
Isotype: IgG1 κ
Applications: Flow Cytometry, Immunohistochemistry (Frozen)
Clone: EH12.2H7
Conjugate: Unconjugated
Gene: Pdcd1
Gene Alias: CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 100135775, 100400173, 101044440, 102123659, 5133, 748796
Content And Storage: 4° C, do not freeze
Form: Liquid
Antigen:
CD279 (PD-1)
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 15mM sodium azide; pH 7.4
Gene Accession No.:
Q15116
Gene Symbols:
Pdcd1
Immunogen:
The exact immunogen is proprietary
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Chimpanzee, Cynomolgus Monkey, Human, Non-human Primate, Rhesus Monkey
Product Type:
Antibody
Isotype:
IgG1 κ
Applications:
Flow Cytometry, Immunohistochemistry (Frozen)
Clone:
EH12.2H7
Conjugate:
Unconjugated
Gene:
Pdcd1
Gene Alias:
CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
100135775, 100400173, 101044440, 102123659, 5133, 748796
Content And Storage:
4° C, do not freeze
Form:
Liquid