PD-L1 Recombinant Rabbit Monoclonal Antibody (015), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Human PD-L1/B7-H1/CD274
• Programmed death receptor ligand 1 (PD-L1, also called B7-H1) is a recently described B7 family member
• To date, one specific receptor has been identified that can be ligated by PD-L1
• This receptor, programmed death receptor 1 (PD-1), has been shown to negatively regulate T-cell receptor (TCR) signaling
• Upon ligating its receptor, PD-L1 has been reported to decrease TCR-mediated proliferation and cytokine production
• PD-L1 expression was found to be abundant on many murine and human cancers and could be further up-regulated upon IFN-gamma stimulation
• Thus, PD-L1 might play an important role in tumor immune evasion.