SARS/SARS-CoV-2 Nucleocapsid Recombinant Rabbit Monoclonal Antibody (001), Invitrogen™

Description

• MA5-29982 cross reacts with SARS-CoV-2 (COVID-19) Nucleoprotein in ELISA and WB
• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Human SARS Coronavirus Nucleoprotein/NP
• SARS-CoV-2 Nucleocapsid Protein is associated with nucleic acid
• It is the most abundant protein for coronavirus
• Because of the strong immunogenicity of coronavirus Nucleocapsid, it is believed that SARS-CoV-2 Nucleocapsid Protein has potential value for the diagnosis of the virus
• The SARS-CoV-2 N protein is an abundant RNA-binding protein critical for viral genome packaging, yet the molecular details that involve this process are poorly understood
• N protein contains three dynamic disordered regions that house putative transiently-helical binding motifs
• The two folded domains interact minimally such that full-length N protein is a flexible and multivalent RNA-binding protein
• SARS-CoV-2 causes illnesses ranging from the common cold to severe diseases.