CRP Recombinant Rabbit Monoclonal Antibody (069), Invitrogen™

Description

• This product is preservative free
• It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%)
• Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
• The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
• Then, individual clones are screened to select the best candidates for production
• The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
• This antibody has specificity for Human CRP/C-Reactive Protein
• CRP (C-reactive protein) is a major cyclic, pentameric acute phase protein compound consisting of five identical, noncovalently bound, nonglycosylated subunits
• Eeach subunit is made up of 206 amino acids, and has a molecular weight of 24 kDa
• CRP is produced by the liver, and its plasma levels rise dramatically during inflammatory processes occurring in the body
• CRP is an initiator of classical complement cascade, binds to several nuclear components (chromatin, histones, etc.), plays an important role in innate immunity, and mediates activities associated with pre-immune nonspecific host resistance
• Specifically, there is a 100-1000 fold increase of CRP in response to injury, infection or inflammation
• CRP is opsonic, an initiator of the classical complement cascade, and an activator of monocytes/macrophages
• CRP also binds to several nuclear components including chromatin, histones and snRNP, suggesting that it may play a role as a scavenger during cell necrosis
• CRP is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host, and initiates pathogen elimination by interacting with humoral and cellular effector systems in the blood
• Patients with elevated basal levels of CRP have been shown to be an increased risk for hypertension and cardiovascular disease.