PIMA532167
ROCK1 Recombinant Rabbit Monoclonal Antibody (ST05-19), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532167-Each-of-1 | In Stock | ₹ 44,619.54 |
PIMA532167 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,619.54
GST (18%): ₹ 8,031.517
Total Price: ₹ 52,651.057
Antigen
ROCK1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P70335, Q13464, Q63644
Gene Symbols
Rock1
Immunogen
Synthetic peptide within Human ROCK1 aa aa 1104-1149
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Immunohistochemistry, Western Blot
Clone
ST05-19
Conjugate
Unconjugated
Gene
Rock1
Gene Alias
1110055K06Rik, Ac2-154, Liver regeneration-related protein LRRG199, MGC131603, MGC43611, p150 RhoA-binding kinase ROK beta, p160 ROCK-1, p160ROCK, p160-ROCK, PRO0435, Renal carcinoma antigen NY-REN-35, Rho associated coiled-coil containing protein kinase 1, Rho kinase, Rho-associated coiled-coil containing protein kinase 1, Rho-associated coiled-coil forming kinase 1, Rho-associated kinase beta, rho-associated protein kinase 1, Rho-associated, coiled-coil containing protein kinase 1, rho-associated, coiled-coil-containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, ROCK1, ROCK-I
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
19877, 6093, 81762
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- ROCK1 is a serine/threonine kinase that regulates cell differentiation and migration
- The Rho/ROCK pathway is involved in the progression of various human cancers
- ROCK1 has been found to be a new Caspase-3 substrate
- ROCK, one of the effectors of the small GTPase Rho, has recently been shown to contribute significantly to myosin light chain (MLC) activation through two pathways: direct phosphorylation of MLC and phosphorylation of MLC phosphatase, leading to its inhibition
- The increase in cellular contractility that is necessary for apoptotic membrane blebbing implies sustained augmentation of MLC phosphorylation
- ROCK-1 consists of an amino-terminal kinase domain and an inhibitory cysteine/histidine-rich C-terminal domain that is located within a pleckstrin-homology region
- They are joined by a variable region that contains the Rho-binding domain
- During apoptosis, ROCK-I is cleaved by caspase-3 at a conserved DETD1113/G sequence and its carboxy-terminal inhibitory domain is removed, resulting in deregulated and constitutive kinase activity
- The caspase-3-mediated cleavage and activation of ROCK I induces phosphorylation of MLC and membrane blebbing, one of the first events in the execution phase of apoptosis.
Compare Similar Items
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Antigen: ROCK1
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P70335, Q13464, Q63644
Gene Symbols: Rock1
Immunogen: Synthetic peptide within Human ROCK1 aa aa 1104-1149
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot, Immunohistochemistry, Western Blot
Clone: ST05-19
Conjugate: Unconjugated
Gene: Rock1
Gene Alias: 1110055K06Rik, Ac2-154, Liver regeneration-related protein LRRG199, MGC131603, MGC43611, p150 RhoA-binding kinase ROK beta, p160 ROCK-1, p160ROCK, p160-ROCK, PRO0435, Renal carcinoma antigen NY-REN-35, Rho associated coiled-coil containing protein kinase 1, Rho kinase, Rho-associated coiled-coil containing protein kinase 1, Rho-associated coiled-coil forming kinase 1, Rho-associated kinase beta, rho-associated protein kinase 1, Rho-associated, coiled-coil containing protein kinase 1, rho-associated, coiled-coil-containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, ROCK1, ROCK-I
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 19877, 6093, 81762
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
ROCK1
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P70335, Q13464, Q63644
Gene Symbols:
Rock1
Immunogen:
Synthetic peptide within Human ROCK1 aa aa 1104-1149
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot, Immunohistochemistry, Western Blot
Clone:
ST05-19
Conjugate:
Unconjugated
Gene:
Rock1
Gene Alias:
1110055K06Rik, Ac2-154, Liver regeneration-related protein LRRG199, MGC131603, MGC43611, p150 RhoA-binding kinase ROK beta, p160 ROCK-1, p160ROCK, p160-ROCK, PRO0435, Renal carcinoma antigen NY-REN-35, Rho associated coiled-coil containing protein kinase 1, Rho kinase, Rho-associated coiled-coil containing protein kinase 1, Rho-associated coiled-coil forming kinase 1, Rho-associated kinase beta, rho-associated protein kinase 1, Rho-associated, coiled-coil containing protein kinase 1, rho-associated, coiled-coil-containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, ROCK1, ROCK-I
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
19877, 6093, 81762
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: Cytokeratin 15
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P19012, Q61414
Gene Symbols: KRT15
Immunogen: Synthetic peptide within Human Cytokeratin 15 aa 410-455
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: ST04-85
Conjugate: Unconjugated
Gene: KRT15
Gene Alias: AI528832, C K1CO, CK15, CK-15, cytokeratin 15, cytokeratin-15, K15, K1CO, Ka15, keratin 15, keratin 15, type I, keratin complex 1, acidic, gene 15, keratin, type I cytoskeletal 15, Keratin-15, keratin-15, basic, keratin-15, beta, KRT1, Krt1-15, KRT15, krt15 {ECO:0000250, KRTB, type I cytoskeletal 15, type I keratin KA15, UniProtKB:P19012}
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 16665, 3866
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Cytokeratin 15
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P19012, Q61414
Gene Symbols:
KRT15
Immunogen:
Synthetic peptide within Human Cytokeratin 15 aa 410-455
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
ST04-85
Conjugate:
Unconjugated
Gene:
KRT15
Gene Alias:
AI528832, C K1CO, CK15, CK-15, cytokeratin 15, cytokeratin-15, K15, K1CO, Ka15, keratin 15, keratin 15, type I, keratin complex 1, acidic, gene 15, keratin, type I cytoskeletal 15, Keratin-15, keratin-15, basic, keratin-15, beta, KRT1, Krt1-15, KRT15, krt15 {ECO:0000250, KRTB, type I cytoskeletal 15, type I keratin KA15, UniProtKB:P19012}
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
16665, 3866
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: Human IgG4
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P01861
Gene Symbols: IGHG4
Immunogen: Synthetic peptide within Human IgG4 aa 85-129
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry, Western Blot
Clone: ST05-12
Conjugate: Unconjugated
Gene: IGHG4
Gene Alias: IGHG4, Immunoglobulin G, Immunoglobulin G4, immunoglobulin heavy constant gamma 4 (G4m marker), ImmunoglobulinG
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 3503
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Human IgG4
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P01861
Gene Symbols:
IGHG4
Immunogen:
Synthetic peptide within Human IgG4 aa 85-129
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry, Western Blot
Clone:
ST05-12
Conjugate:
Unconjugated
Gene:
IGHG4
Gene Alias:
IGHG4, Immunoglobulin G, Immunoglobulin G4, immunoglobulin heavy constant gamma 4 (G4m marker), ImmunoglobulinG
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
3503
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: Cyclophilin B
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P23284, P24368, P24369
Gene Symbols: PPIB
Immunogen: Synthetic peptide within Human Cyclophilin B aa 171-215
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Western Blot
Clone: ST05-22
Conjugate: Unconjugated
Gene: PPIB
Gene Alias: AA408962, AA553318, AI844835, Cphn2, Cphn-2, cyclophilin B, cyclophilin-like protein, Cyp B, CyP-20b, CYPB, CYP-S1, EC 5.2.1.8, epididymis secretory protein Li 39, HEL-S-39, OI9, Peptidyl-prolyl cis-trans isomerase B, peptidylprolyl isomerase B, peptidylprolyl isomerase B (cyclophilin B), PPIase, PPIase B, Ppib, Rotamase, Rotamase B, S-cyclophilin, S-cyclophylin, SCYLP
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 19035, 5479, 64367
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Cyclophilin B
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P23284, P24368, P24369
Gene Symbols:
PPIB
Immunogen:
Synthetic peptide within Human Cyclophilin B aa 171-215
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Western Blot
Clone:
ST05-22
Conjugate:
Unconjugated
Gene:
PPIB
Gene Alias:
AA408962, AA553318, AI844835, Cphn2, Cphn-2, cyclophilin B, cyclophilin-like protein, Cyp B, CyP-20b, CYPB, CYP-S1, EC 5.2.1.8, epididymis secretory protein Li 39, HEL-S-39, OI9, Peptidyl-prolyl cis-trans isomerase B, peptidylprolyl isomerase B, peptidylprolyl isomerase B (cyclophilin B), PPIase, PPIase B, Ppib, Rotamase, Rotamase B, S-cyclophilin, S-cyclophylin, SCYLP
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
19035, 5479, 64367
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid