PIMA532507
TPA Recombinant Rabbit Monoclonal Antibody (JF0958), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532507-Each-of-1 | In Stock | ₹ 45,646.26 |
PIMA532507 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,646.26
GST (18%): ₹ 8,216.327
Total Price: ₹ 53,862.587
Antigen
TPA
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P00750, P11214, P19637
Gene Symbols
PLAT
Immunogen
Synthetic peptide within Human Tissue-type plasminogen activator aa 523-562
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry, Western Blot
Clone
JF0958
Conjugate
Unconjugated
Gene
PLAT
Gene Alias
3.4.21.68, Alteplase, AU020998, AW212668, D8Ertd2e, PATISS, plasminogen activator, tissue, plasminogen activator, tissue type, plasminogen/activator kringle, PLAT, Reteplase, serine protease, t plasminogen activator, tissue plasminogen activator, tissue-type plasminogen activator, Tissue-type plasminogen activator chain A, Tissue-type plasminogen activator chain B, TPA, t-PA, t-plasminogen activator
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
18791, 25692, 5327
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- TPA converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen
- By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physio pathological events
- It specifically cleaves the Arg- -Val bond in plasminogen to form plasmin, and is comprised of a heterodimer of chain A and chain B held by a disulfide bond
- TPA binds to fibrin with high affinity
- This interaction leads to an increase in the catalytic efficiency of the enzyme between 100-and 1000-fold, due to an increase in affinity for plasminogen
- Similarly, binding to heparin increases the activation of plasminogen
- Binding to laminin and fibronectin has also been demonstrated
- TPA also binds to mannose receptor and the low-density lipoprotein receptor-related protein (LRP1)
- These proteins are involved in TPA clearance
- TPA binds to annexin II and to cytokeratin 8
- As yet unidentified interactions on endothelial cells and vascular smooth muscle cells (VSMC) lead to a 100-fold stimulation of plasminogen activation
- In addition, binding to VSMC reduces TPA inhibition by PAI-1 by 30-fold.
Compare Similar Items
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Antigen: TPA
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P00750, P11214, P19637
Gene Symbols: PLAT
Immunogen: Synthetic peptide within Human Tissue-type plasminogen activator aa 523-562
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry, Western Blot
Clone: JF0958
Conjugate: Unconjugated
Gene: PLAT
Gene Alias: 3.4.21.68, Alteplase, AU020998, AW212668, D8Ertd2e, PATISS, plasminogen activator, tissue, plasminogen activator, tissue type, plasminogen/activator kringle, PLAT, Reteplase, serine protease, t plasminogen activator, tissue plasminogen activator, tissue-type plasminogen activator, Tissue-type plasminogen activator chain A, Tissue-type plasminogen activator chain B, TPA, t-PA, t-plasminogen activator
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 18791, 25692, 5327
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
TPA
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P00750, P11214, P19637
Gene Symbols:
PLAT
Immunogen:
Synthetic peptide within Human Tissue-type plasminogen activator aa 523-562
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry, Western Blot
Clone:
JF0958
Conjugate:
Unconjugated
Gene:
PLAT
Gene Alias:
3.4.21.68, Alteplase, AU020998, AW212668, D8Ertd2e, PATISS, plasminogen activator, tissue, plasminogen activator, tissue type, plasminogen/activator kringle, PLAT, Reteplase, serine protease, t plasminogen activator, tissue plasminogen activator, tissue-type plasminogen activator, Tissue-type plasminogen activator chain A, Tissue-type plasminogen activator chain B, TPA, t-PA, t-plasminogen activator
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
18791, 25692, 5327
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: TK1
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P04183
Gene Symbols: TK1
Immunogen: Synthetic peptide within Human Thymidine Kinase 1 aa 2-49
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: JF0970
Conjugate: Unconjugated
Gene: TK1
Gene Alias: D530002A18Rik, EC 2.7.1.21, KITH, thymidine kinase 1, thymidine kinase 1 soluble isoform, thymidine kinase 1, soluble, thymidine kinase, cytosolic, thymidine kinase-1, Tk, Tk1, Tk-1, Tk1a, Tk1b, TK2
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 7083
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
TK1
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P04183
Gene Symbols:
TK1
Immunogen:
Synthetic peptide within Human Thymidine Kinase 1 aa 2-49
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
JF0970
Conjugate:
Unconjugated
Gene:
TK1
Gene Alias:
D530002A18Rik, EC 2.7.1.21, KITH, thymidine kinase 1, thymidine kinase 1 soluble isoform, thymidine kinase 1, soluble, thymidine kinase, cytosolic, thymidine kinase-1, Tk, Tk1, Tk-1, Tk1a, Tk1b, TK2
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
7083
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: gamma Tubulin
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P23258, P83887, P83888, Q0VCD2, Q32KM1, Q8VCK3, Q9GKK5, Q9NRH3
Gene Symbols: TUBG1, tubg1.L, Tubg2
Immunogen: Recombinant protein within Human Tubulin gamma-2 chain aa 227-407
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bovine, Canine, Chicken, Fish, Hamster, Human, Mouse, Non-human Primate, Rat, X. laevis
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: JF0972
Conjugate: Unconjugated
Gene: TUBG1
Gene Alias: 1500010O08Rik, AI451582, AI503389, AI504772, CDCBM4, centrosome marker, gamma tubulin, gamma-1-tubulin, Gamma-2-tubulin, gamma-tubulin, gamma-tubulin complex component 1, GCP-1, similar to tubulin, gamma 1, Tubg, TUBG1, tubg1.L, TUBG2, TUBGCP1, Tubgl, tubulin gamma 1, tubulin gamma 1 L homeolog, tubulin gamma 2, Tubulin gamma-1 chain, Tubulin gamma-2 chain, tubulin, gamma 1, tubulin, gamma 2, tubulin, gamma polypeptide, Unknown (protein for MGC:133882), XELAEV_18002398mg, xgam, zgc:55894
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 100759432, 103733, 103768, 252921, 27175, 399272, 403695, 420025, 490962, 540216, 541101, 680991, 7283
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
gamma Tubulin
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P23258, P83887, P83888, Q0VCD2, Q32KM1, Q8VCK3, Q9GKK5, Q9NRH3
Gene Symbols:
TUBG1, tubg1.L, Tubg2
Immunogen:
Recombinant protein within Human Tubulin gamma-2 chain aa 227-407
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Canine, Chicken, Fish, Hamster, Human, Mouse, Non-human Primate, Rat, X. laevis
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
JF0972
Conjugate:
Unconjugated
Gene:
TUBG1
Gene Alias:
1500010O08Rik, AI451582, AI503389, AI504772, CDCBM4, centrosome marker, gamma tubulin, gamma-1-tubulin, Gamma-2-tubulin, gamma-tubulin, gamma-tubulin complex component 1, GCP-1, similar to tubulin, gamma 1, Tubg, TUBG1, tubg1.L, TUBG2, TUBGCP1, Tubgl, tubulin gamma 1, tubulin gamma 1 L homeolog, tubulin gamma 2, Tubulin gamma-1 chain, Tubulin gamma-2 chain, tubulin, gamma 1, tubulin, gamma 2, tubulin, gamma polypeptide, Unknown (protein for MGC:133882), XELAEV_18002398mg, xgam, zgc:55894
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
100759432, 103733, 103768, 252921, 27175, 399272, 403695, 420025, 490962, 540216, 541101, 680991, 7283
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: CD99
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.: P14209
Gene Symbols: CD99
Immunogen: Recombinant protein within Human CD99 aa 1-130
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone: JF0991
Conjugate: Unconjugated
Gene: CD99
Gene Alias: 1110061M03Rik, 12E7, 2410026K10Rik, antigen identified by monoclonal 12E7, Y homolog, antigen identified by monoclonal antibodies 12E7, F21 and O13, Cd99, CD99 antigen, CD99 molecule, cell surface antigen 12E7, cell surface antigen HBA-71, cell surface antigen O13, D4, E2 antigen, HBA71, MIC2, MIC2 (monoclonal antibody 12E7), MIC2X, MIC2Y, MSK5X, paired immunoglobin-like type 2 receptor-ligand, pilr-1, Pilrl, PILR-L, Protein MIC2, surface antigen MIC2, T-cell surface glycoprotein E2
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 4267
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
CD99
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.:
P14209
Gene Symbols:
CD99
Immunogen:
Recombinant protein within Human CD99 aa 1-130
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone:
JF0991
Conjugate:
Unconjugated
Gene:
CD99
Gene Alias:
1110061M03Rik, 12E7, 2410026K10Rik, antigen identified by monoclonal 12E7, Y homolog, antigen identified by monoclonal antibodies 12E7, F21 and O13, Cd99, CD99 antigen, CD99 molecule, cell surface antigen 12E7, cell surface antigen HBA-71, cell surface antigen O13, D4, E2 antigen, HBA71, MIC2, MIC2 (monoclonal antibody 12E7), MIC2X, MIC2Y, MSK5X, paired immunoglobin-like type 2 receptor-ligand, pilr-1, Pilrl, PILR-L, Protein MIC2, surface antigen MIC2, T-cell surface glycoprotein E2
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
4267
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid