PIMA533091
CD163 Recombinant Rabbit Monoclonal Antibody (RM371), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA533091-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA533091 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
CD163
Classification
Recombinant Monoclonal
Concentration
0.2 mg/mL
Formulation
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.
Q86VB7
Gene Symbols
CD163
Immunogen
A peptide corresponding to the N-terminus of human CD163.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
RM371
Conjugate
Unconjugated
Gene
CD163
Gene Alias
CD163, CD163 antigen, CD163 molecule, CD163v2, CD163v3, Hemoglobin scavenger receptor, M130, macrophage-associated antigen, MM130, putative CD163 antigen, SCARI1, Scavenger receptor cysteine-rich type 1 protein M130, sCD163, Soluble CD163, Soluble sCD163
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
9332
Content And Storage
-20°C
Form
Liquid
Related Products
Description
- Specificity: reacts to human CD163
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein, a member of the scavenger receptor cysteine-rich superfamily, and a receptor for the hemoglobin-haptoglobin complex
- CD163 protects tissues from free hemoglobin-mediated oxidative damage, and may play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme
- CD163 is expressed exclusively on the cell surface of human monocytes and macrophages that evolve predominantly in the late phase of inflammation
- Specifically, CD163 is present on all circulating monocytes and most tissue macrophages except those found in the mantle zone and germinal centers of lymphoid follicles, interdigitating reticulum cells and Langerhan's cells
- CD163 is present on all CD14 positive monocytes, most CD64 positive monocytes, and shows higher expression on CD16 positive monocytes
- CD163 is upregulated on mononuclear phagocytes by IL-10, IL-6 and dexamethasone
- Lipopolysaccharide (LPS) and phorbol myristate acetate (PMA) both induce shedding of CD163 from the cell surface into plasma or cell supernatant
- CD163 binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner, and exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP1S phenotype
- Further, CD163 also induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1.
Compare Similar Items
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Antigen: CD163
Classification: Recombinant Monoclonal
Concentration: 0.2 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.: Q86VB7
Gene Symbols: CD163
Immunogen: A peptide corresponding to the N-terminus of human CD163.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: RM371
Conjugate: Unconjugated
Gene: CD163
Gene Alias: CD163, CD163 antigen, CD163 molecule, CD163v2, CD163v3, Hemoglobin scavenger receptor, M130, macrophage-associated antigen, MM130, putative CD163 antigen, SCARI1, Scavenger receptor cysteine-rich type 1 protein M130, sCD163, Soluble CD163, Soluble sCD163
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 9332
Content And Storage: -20°C
Form: Liquid
Antigen:
CD163
Classification:
Recombinant Monoclonal
Concentration:
0.2 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.:
Q86VB7
Gene Symbols:
CD163
Immunogen:
A peptide corresponding to the N-terminus of human CD163.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
RM371
Conjugate:
Unconjugated
Gene:
CD163
Gene Alias:
CD163, CD163 antigen, CD163 molecule, CD163v2, CD163v3, Hemoglobin scavenger receptor, M130, macrophage-associated antigen, MM130, putative CD163 antigen, SCARI1, Scavenger receptor cysteine-rich type 1 protein M130, sCD163, Soluble CD163, Soluble sCD163
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
9332
Content And Storage:
-20°C
Form:
Liquid
Antigen: ALK
Classification: Recombinant Monoclonal
Concentration: 0.1 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.: Q9UM73
Gene Symbols: ALK
Immunogen: A peptide corresponding to the C-terminus of human ALK (Anaplastic lymphoma kinase).
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: RM361
Conjugate: Unconjugated
Gene: ALK
Gene Alias: Alk, ALK tyrosine kinase receptor, ALK/NPM1 fusion gene, anaplastic lymphoma kinase, Anaplastic lymphoma kinase Ki1, Anaplastic Lymphoma Kinase p80, anaplastic lymphoma receptor tyrosine kinase, CD246, CD246 antigen, EC 2.7.10.1, kinase ALK, mutant anaplastic lymphoma kinase, NBLST3, npm-alk, p80, Tcrz, TFG/ALK
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 238
Content And Storage: -20°C
Form: Liquid
Antigen:
ALK
Classification:
Recombinant Monoclonal
Concentration:
0.1 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.:
Q9UM73
Gene Symbols:
ALK
Immunogen:
A peptide corresponding to the C-terminus of human ALK (Anaplastic lymphoma kinase).
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
RM361
Conjugate:
Unconjugated
Gene:
ALK
Gene Alias:
Alk, ALK tyrosine kinase receptor, ALK/NPM1 fusion gene, anaplastic lymphoma kinase, Anaplastic lymphoma kinase Ki1, Anaplastic Lymphoma Kinase p80, anaplastic lymphoma receptor tyrosine kinase, CD246, CD246 antigen, EC 2.7.10.1, kinase ALK, mutant anaplastic lymphoma kinase, NBLST3, npm-alk, p80, Tcrz, TFG/ALK
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
238
Content And Storage:
-20°C
Form:
Liquid
Antigen: SATB2
Classification: Recombinant Monoclonal
Concentration: 0.5 mg/mL
Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.: Q9UPW6
Gene Symbols: SATB2
Immunogen: A peptide corresponding to the C-terminus of human DNA-binding protein SATB2.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: RM365
Conjugate: Unconjugated
Gene: SATB2
Gene Alias: DNA-binding protein SATB2, FLJ21474, FLJ32076, GLSS, KIAA1034, KIAA1034-like DNA binding protein, MGC119474, MGC119477, mKIAA1034, RGD1562369, SATB family member 2, SATB homeobox 2, SATB2, special AT-rich sequence binding protein 2, special AT-rich sequence-binding protein 2, two cut domains-containing homeodomain protein
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 23314
Content And Storage: -20°C
Form: Liquid
Antigen:
SATB2
Classification:
Recombinant Monoclonal
Concentration:
0.5 mg/mL
Formulation:
PBS with 1% BSA, 50% glycerol and 0.09% sodium azide
Gene Accession No.:
Q9UPW6
Gene Symbols:
SATB2
Immunogen:
A peptide corresponding to the C-terminus of human DNA-binding protein SATB2.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
RM365
Conjugate:
Unconjugated
Gene:
SATB2
Gene Alias:
DNA-binding protein SATB2, FLJ21474, FLJ32076, GLSS, KIAA1034, KIAA1034-like DNA binding protein, MGC119474, MGC119477, mKIAA1034, RGD1562369, SATB family member 2, SATB homeobox 2, SATB2, special AT-rich sequence binding protein 2, special AT-rich sequence-binding protein 2, two cut domains-containing homeodomain protein
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
23314
Content And Storage:
-20°C
Form:
Liquid
Antigen: ABCA4
Classification: Monoclonal
Concentration: ∽1 mg/mL
Formulation: 10mM HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative, pH 7.5
Gene Accession No.: O35600, P78363
Gene Symbols: ABCA4, abca4.L
Immunogen: Partially purified bovine 220-kDa disc rim protein
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bovine, Human, Mouse, X. laevis
Product Type: Antibody
Isotype: IgG1
Applications: Immunohistochemistry, Western Blot
Clone: 3F4
Conjugate: Unconjugated
Gene: ABCA4
Gene Alias: ABC transporter, ABC10, abca4, abca4.L, Abcr, ARMD2, ATP binding cassette subfamily A member 4, ATP binding cassette subfamily A member 4 L homeolog, ATP binding cassette transporter, ATP-binding cassette 10, ATP-binding cassette sub-family A member 4, ATP-binding cassette transporter, retinal-specific, ATP-binding cassette, subfamily A (ABC1), member 4, ATP-binding cassette, sub-family A (ABC1), member 4, ATP-binding cassette, sub-family A, member 4, ATP-binding transporter, retina-specific, AW050280, CORD3, D430003I15Rik, FFM, photoreceptor rim protein, retinal ABCA4 transporter, retinal-specific ATP-binding cassette transporter, Retinal-specific phospholipid-transporting ATPase ABCA4, retina-specific ABC transporter, RIM ABC transporter, RIM protein, RMP, RP19, Stargardt disease protein, STGD, STGD1, XELAEV_180233141mg
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 11304, 24, 281584, 497268
Content And Storage: -20°, C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
ABCA4
Classification:
Monoclonal
Concentration:
∽1 mg/mL
Formulation:
10mM HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and no preservative, pH 7.5
Gene Accession No.:
O35600, P78363
Gene Symbols:
ABCA4, abca4.L
Immunogen:
Partially purified bovine 220-kDa disc rim protein
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Human, Mouse, X. laevis
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunohistochemistry, Western Blot
Clone:
3F4
Conjugate:
Unconjugated
Gene:
ABCA4
Gene Alias:
ABC transporter, ABC10, abca4, abca4.L, Abcr, ARMD2, ATP binding cassette subfamily A member 4, ATP binding cassette subfamily A member 4 L homeolog, ATP binding cassette transporter, ATP-binding cassette 10, ATP-binding cassette sub-family A member 4, ATP-binding cassette transporter, retinal-specific, ATP-binding cassette, subfamily A (ABC1), member 4, ATP-binding cassette, sub-family A (ABC1), member 4, ATP-binding cassette, sub-family A, member 4, ATP-binding transporter, retina-specific, AW050280, CORD3, D430003I15Rik, FFM, photoreceptor rim protein, retinal ABCA4 transporter, retinal-specific ATP-binding cassette transporter, Retinal-specific phospholipid-transporting ATPase ABCA4, retina-specific ABC transporter, RIM ABC transporter, RIM protein, RMP, RP19, Stargardt disease protein, STGD, STGD1, XELAEV_180233141mg
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
11304, 24, 281584, 497268
Content And Storage:
-20°, C, Avoid Freeze/Thaw Cycles
Form:
Liquid