PIMA538273
SMCR8 Recombinant Rabbit Monoclonal Antibody (HL1007), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA538273-Each-of-1 | In Stock | ₹ 46,501.86 |
PIMA538273 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,501.86
GST (18%): ₹ 8,370.335
Total Price: ₹ 54,872.195
Antigen
SMCR8
Classification
Recombinant Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
Q3UMB5, Q8TEV9
Gene Symbols
SMCR8
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SMCR8. The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone
HL1007
Conjugate
Unconjugated
Gene
SMCR8
Gene Alias
2310076G09Rik; AI642055; D030073L15Rik; FLJ34716; Guanine nucleotide exchange protein SMCR8; RGD1564621; SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein; Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog; Smith-Magenis syndrome chromosome region, candidate 8; Smith-Magenis syndrome chromosome region, candidate 8 homolog; Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
140775, 237782, 497918
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Centrifuge briefly prior to opening
- Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy
- In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation
- The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity
- Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates
- In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes.
Compare Similar Items
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Antigen: SMCR8
Classification: Recombinant Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: Q3UMB5, Q8TEV9
Gene Symbols: SMCR8
Immunogen: Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SMCR8. The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: HL1007
Conjugate: Unconjugated
Gene: SMCR8
Gene Alias: 2310076G09Rik; AI642055; D030073L15Rik; FLJ34716; Guanine nucleotide exchange protein SMCR8; RGD1564621; SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein; Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog; Smith-Magenis syndrome chromosome region, candidate 8; Smith-Magenis syndrome chromosome region, candidate 8 homolog; Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 140775, 237782, 497918
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Form: Liquid
Antigen:
SMCR8
Classification:
Recombinant Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
Q3UMB5, Q8TEV9
Gene Symbols:
SMCR8
Immunogen:
Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human SMCR8. The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
HL1007
Conjugate:
Unconjugated
Gene:
SMCR8
Gene Alias:
2310076G09Rik; AI642055; D030073L15Rik; FLJ34716; Guanine nucleotide exchange protein SMCR8; RGD1564621; SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein; Smith-Magenis syndrome chromosomal region candidate gene 8 protein homolog; Smith-Magenis syndrome chromosome region, candidate 8; Smith-Magenis syndrome chromosome region, candidate 8 homolog; Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
140775, 237782, 497918
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Form:
Liquid
Antigen: Sumo Tag
Classification: Monoclonal
Concentration: 3.84 mg/mL
Formulation: 10mM PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.: __
Gene Symbols: __
Immunogen: sumo tag protein
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Tag
Product Type: Antibody
Isotype: IgG1
Applications: Western Blot
Clone: __
Conjugate: Unconjugated
Gene: __
Gene Alias: SUMO; SUMO tag
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Antigen:
Sumo Tag
Classification:
Monoclonal
Concentration:
3.84 mg/mL
Formulation:
10mM PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.:
__
Gene Symbols:
__
Immunogen:
sumo tag protein
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Tag
Product Type:
Antibody
Isotype:
IgG1
Applications:
Western Blot
Clone:
__
Conjugate:
Unconjugated
Gene:
__
Gene Alias:
SUMO; SUMO tag
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
__
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid
Antigen: E Tag
Classification: Monoclonal
Concentration: 0.34 mg/mL
Formulation: 10mM PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.: __
Gene Symbols: __
Immunogen: GAPVPYPDPLEPRC synthetic peptide conjugate to KLH
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Tag
Product Type: Antibody
Isotype: IgG1
Applications: Immunoprecipitation, Western Blot
Clone: 11H12B3
Conjugate: Unconjugated
Gene: __
Gene Alias: E epitope tag; GAPVPYPDPLEPR; GAPVPYPDPLEPR tag
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Antigen:
E Tag
Classification:
Monoclonal
Concentration:
0.34 mg/mL
Formulation:
10mM PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.:
__
Gene Symbols:
__
Immunogen:
GAPVPYPDPLEPRC synthetic peptide conjugate to KLH
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Tag
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunoprecipitation, Western Blot
Clone:
11H12B3
Conjugate:
Unconjugated
Gene:
__
Gene Alias:
E epitope tag; GAPVPYPDPLEPR; GAPVPYPDPLEPR tag
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
__
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid
Antigen: E. coli GLB1
Classification: Monoclonal
Concentration: 2.54 mg/mL
Formulation: 10mM PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.: __
Gene Symbols: __
Immunogen: Recombinant Escherichia coli Beta-galactosidase protein
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Bacteria
Product Type: Antibody
Isotype: IgG1
Applications: Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone: 3B7D5
Conjugate: Unconjugated
Gene: __
Gene Alias: acid beta-galactosidase; AW125515; betagal; Beta-Gal; Beta-galactosidase; bgal; Bge; Bgl; Bgl-e; Bgl-s; Bgl-t; Bgs; Bgt; C130097A14Rik; EBP; Elastin receptor 1; elastin receptor 1, 67kDa; ELNR1; galactosidase beta 1; galactosidase, beta 1; GLB1; Glb-1; lactase; lysosmal hydrolase; lysosomal beta-galactosidase; lysosomal hydrolase; MPS4B; βgal; β-gal; β-galactosidase
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: -20°C or -80°C if preferred
Form: Liquid
Antigen:
E. coli GLB1
Classification:
Monoclonal
Concentration:
2.54 mg/mL
Formulation:
10mM PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene Accession No.:
__
Gene Symbols:
__
Immunogen:
Recombinant Escherichia coli Beta-galactosidase protein
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Bacteria
Product Type:
Antibody
Isotype:
IgG1
Applications:
Flow Cytometry, Immunocytochemistry, Immunoprecipitation, Western Blot
Clone:
3B7D5
Conjugate:
Unconjugated
Gene:
__
Gene Alias:
acid beta-galactosidase; AW125515; betagal; Beta-Gal; Beta-galactosidase; bgal; Bge; Bgl; Bgl-e; Bgl-s; Bgl-t; Bgs; Bgt; C130097A14Rik; EBP; Elastin receptor 1; elastin receptor 1, 67kDa; ELNR1; galactosidase beta 1; galactosidase, beta 1; GLB1; Glb-1; lactase; lysosmal hydrolase; lysosomal beta-galactosidase; lysosomal hydrolase; MPS4B; βgal; β-gal; β-galactosidase
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
__
Content And Storage:
-20°C or -80°C if preferred
Form:
Liquid