Bavituximab Recombinant Human Monoclonal Antibody, Invitrogen™

Description

• Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles
• Store at 2 to 8 °C for one week
• Store at -20 to -80 °C for twelve months from the date of receipt
• Bavituximab is a chimeric Anti-PS monoclonal antibody analog which is used to potentially treat cancers and viral infections
• It binds to phosphatidylserine and other exposed host cell lipids when induced by cellular stress
• Additional analogs in the class include 3G4, 2aG4, 9d2 and Hu3g4
• Bavituximab Anti-Cancer is a monoclonal antibody that binds to a basic component of the cell structure called a phospholipid that is exposed only on the surface of tumor blood vessel cells or on cells infected with certain viruses
• Bavituximab binding to the tumor blood vessel cells alerts the body's immune system to attack the tumor and its blood supply
• This has been shown to inhibit tumor growth and development
• Because in healthy cells the phospholipids are concealed inside the cell, the bavituximab does not bind to them
• This targets the bavituximab to the malignant cells and potentially minimizes unwanted side effects.