Batoclimab Recombinant Human Monoclonal Antibody, Invitrogen™

Description

• Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles
• Store at 2 to 8 °C for one week
• Store at -20 to -80 °C for twelve months from the date of receipt
• Batoclimab (HBM9161) is a fully human antibody targeting the neonatal Fc receptor (FcRn)
• It targets patients with neuromyelitis optica spectrum diseases and other autoimmune diseases, and can accelerate the degradation of autoantibodies in their bodies
• Batoclimab (HBM9161) is an antibody that targets the neonatal Fc receptor (FcRn)
• FcRn expression is up-regulated by pro-inflammatory cytokines (such as TNF-alpha) and prolongs the half-life of IgG and serum albumin by reducing lysosomal degradation in endothelial cells and bone marrow-derived cells
• Blocking the FcRn-IgG interaction can accelerate the degradation of autoantibodies and reduce the onset of various pathogenic IgG-mediated autoimmune diseases, including myasthenia gravis, thyroid ophthalmopathy, neuromyelitis optica spectrum disease and immunity Thrombocytopenia.