SIRP alpha Monoclonal Antibody (15-414), PE, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA544115-Each-of-1 | In Stock | ₹ 40,555.44 |
PIMA544115 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,555.44
GST (18%): ₹ 7,299.979
Total Price: ₹ 47,855.419
Antigen
SIRP alpha
Classification
Monoclonal
Concentration
0.080 mg/mL
Formulation
PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene Accession No.
P78324
Gene Symbols
SIRPA
Immunogen
Kg-1a cell line
Quantity
100 Tests
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG2a
Applications
Flow Cytometry
Clone
15-414
Conjugate
PE
Gene
SIRPA
Gene Alias
AI835480; Bit; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; brain immunological-like with tyrosine-based motifs; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172; CD172 alpha; CD172 antigen-like family member A; CD172A; Inhibitory receptor SHPS-1; macrophage fusion receptor; Macrophage membrane protein MFP150; MFR; mSIRP-alpha1; Myd1; MYD-1; myD-1 antigen; p84; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHP-1; SHPS1; SHPS-1; signal regulatory protein alpha; signal-regulatory protein alpha; signal-regulatory protein alpha-1; Signal-regulatory protein alpha-2; Signal-regulatory protein alpha-3; SIRP; Sirpa; SIRPalpha; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3; swc3; swine workshop cluster 3 antigen; swine workshop cluster 3 antigen precursor; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1
Host Species
Mouse
Purification Method
Size-exclusion chromatography
Regulatory Status
RUO
Gene ID (Entrez)
140885
Content And Storage
4° C, store in dark, DO NOT FREEZE!
Form
Liquid
Related Products
Description
- SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and hematopoietic stem cells
- SIRP alpha acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways
- The ligand binding of SIRP alpha to integrin-associated protein CD47 results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of SIRP alpha, which mediates the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2
- Ligation of SIRP alpha with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs
- SIRP alpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion, and plays a general role in different physiological and pathological processes
- Cancer cells highly express CD47, which activates SIRP alpha and inhibits macrophage-mediated destruction of cancerous cell growth.
Compare Similar Items
Show Difference
Antigen: SIRP alpha
Classification: Monoclonal
Concentration: 0.080 mg/mL
Formulation: PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene Accession No.: P78324
Gene Symbols: SIRPA
Immunogen: Kg-1a cell line
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG2a
Applications: Flow Cytometry
Clone: 15-414
Conjugate: PE
Gene: SIRPA
Gene Alias: AI835480; Bit; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; brain immunological-like with tyrosine-based motifs; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172; CD172 alpha; CD172 antigen-like family member A; CD172A; Inhibitory receptor SHPS-1; macrophage fusion receptor; Macrophage membrane protein MFP150; MFR; mSIRP-alpha1; Myd1; MYD-1; myD-1 antigen; p84; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHP-1; SHPS1; SHPS-1; signal regulatory protein alpha; signal-regulatory protein alpha; signal-regulatory protein alpha-1; Signal-regulatory protein alpha-2; Signal-regulatory protein alpha-3; SIRP; Sirpa; SIRPalpha; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3; swc3; swine workshop cluster 3 antigen; swine workshop cluster 3 antigen precursor; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1
Host Species: Mouse
Purification Method: Size-exclusion chromatography
Regulatory Status: RUO
Gene ID (Entrez): 140885
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Antigen: HLA-ABCE
Classification: Monoclonal
Concentration: 0.1 mg/mL
Formulation: PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene Accession No.: P01889, P04439, P10321, P13747
Gene Symbols: HLA-A, HLA-B, HLA-C, HLA-E
Immunogen: IFN-gamma-treated human melanoma cells Colo 38
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human
Product Type: Antibody
Isotype: IgG1
Applications: Flow Cytometry
Clone: TP25.99SF
Conjugate: PE
Gene: HLA-C
Gene Alias: PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Host Species: Mouse
Purification Method: Size-exclusion chromatography
Regulatory Status: RUO
Gene ID (Entrez): 3105, 3106, 3107, 3133
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Antigen: TCR V gamma 9
Classification: Monoclonal
Concentration: 0.080 mg/mL
Formulation: PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Gene Accession No.: 0
Gene Symbols: TRG
Immunogen: human T cells
Quantity: 100 Tests
Primary or Secondary: Primary
Target Species: Human, Non-human Primate
Product Type: Antibody
Isotype: IgG1
Applications: Flow Cytometry
Clone: B3
Conjugate: PE
Gene: TRG
Gene Alias: PBS with 0.2% BSA and 15mM sodium azide; pH 7.4
Host Species: Mouse
Purification Method: Size-exclusion chromatography
Regulatory Status: RUO
Gene ID (Entrez): 6965
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid