PIMA545676
SHANK1/SHANK3 Monoclonal Antibody (S367-51), PE, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA545676-Each-of-1 | In Stock | ₹ 38,758.68 |
PIMA545676 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,758.68
GST (18%): ₹ 6,976.562
Total Price: ₹ 45,735.242
Antigen
SHANK1/SHANK3
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
2.15mM MES, 47.35mM phosphate with 1.033mM EDTA and no preservative; pH 7.4
Gene Accession No.
D3YZU1, Q4ACU6, Q9BYB0, Q9JLU4, Q9WV48, Q9Y566
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
243961, 50944, 58234, 59312, 78957, 85358
Content And Storage
4° C
Isotype
IgG2a
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
S367-51
Conjugate
PE
Gene
Shank3
Gene Symbols
Shank1, Shank3
Immunogen
Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Related Products
Description
- Mouse: 100% identity (89/89 amino acids identical)
- Human: 97% identity (87/89 amino acids identical)
- ∽70% identity with SHANK1 and SHANK2
- 1 μg/mL of MA5-45676 was sufficient for detection of SHANK1/SHANK3 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.∣Detects approximately 190kDa
- Cross-reacts with SHANK1
- Does not cross-react with SHANK2
- Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance
- Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton
- Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters
- By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling
- Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity
- May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation
- {PubMed:21606927, PubMed:21795692, PubMed:23100419, PubMed:23897824, PubMed:24089484}.
Compare Similar Items
Show Difference
Antigen: SHANK1/SHANK3
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: 2.15mM MES, 47.35mM phosphate with 1.033mM EDTA and no preservative; pH 7.4
Gene Accession No.: D3YZU1, Q4ACU6, Q9BYB0, Q9JLU4, Q9WV48, Q9Y566
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 243961, 50944, 58234, 59312, 78957, 85358
Content And Storage: 4° C
Isotype: IgG2a
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: S367-51
Conjugate: PE
Gene: Shank3
Gene Symbols: Shank1, Shank3
Immunogen: Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
SHANK1/SHANK3
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
2.15mM MES, 47.35mM phosphate with 1.033mM EDTA and no preservative; pH 7.4
Gene Accession No.:
D3YZU1, Q4ACU6, Q9BYB0, Q9JLU4, Q9WV48, Q9Y566
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
243961, 50944, 58234, 59312, 78957, 85358
Content And Storage:
4° C
Isotype:
IgG2a
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
S367-51
Conjugate:
PE
Gene:
Shank3
Gene Symbols:
Shank1, Shank3
Immunogen:
Fusion protein amino acids 538-626 (SH3 domain) of rat SHANK3.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Antigen: LGI1
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: 2.15mM MES, 47.35mM phosphate with 1.033mM EDTA and no preservative; pH 7.4
Gene Accession No.: O95970, Q8K4Y5, Q9JIA1
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 252892, 56839, 9211
Content And Storage: 4° C
Isotype: IgG2a
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: S283-7
Conjugate: APC
Gene: LGI1
Gene Symbols: LGI1
Immunogen: Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
LGI1
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
2.15mM MES, 47.35mM phosphate with 1.033mM EDTA and no preservative; pH 7.4
Gene Accession No.:
O95970, Q8K4Y5, Q9JIA1
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
252892, 56839, 9211
Content And Storage:
4° C
Isotype:
IgG2a
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
S283-7
Conjugate:
APC
Gene:
LGI1
Gene Symbols:
LGI1
Immunogen:
Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Antigen: LGI1
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: 9.1mM sodium bicarbonate, 9.44mM PBS with 123mM ethanolamine, 581mM DMSO and no preservative; pH 7.4
Gene Accession No.: O95970, Q8K4Y5, Q9JIA1
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 252892, 56839, 9211
Content And Storage: 4° C, store in dark
Isotype: IgG2a
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: S283-7
Conjugate: FITC
Gene: LGI1
Gene Symbols: LGI1
Immunogen: Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
LGI1
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
9.1mM sodium bicarbonate, 9.44mM PBS with 123mM ethanolamine, 581mM DMSO and no preservative; pH 7.4
Gene Accession No.:
O95970, Q8K4Y5, Q9JIA1
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
252892, 56839, 9211
Content And Storage:
4° C, store in dark
Isotype:
IgG2a
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
S283-7
Conjugate:
FITC
Gene:
LGI1
Gene Symbols:
LGI1
Immunogen:
Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Antigen: LGI1
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: 2.15mM MES, 47.35mM phosphate with 1.033mM EDTA and no preservative; pH 7.4
Gene Accession No.: O95970, Q8K4Y5, Q9JIA1
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 252892, 56839, 9211
Content And Storage: 4° C
Isotype: IgG2a
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: S283-7
Conjugate: PE
Gene: LGI1
Gene Symbols: LGI1
Immunogen: Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1.
Quantity: 100 μg
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Antigen:
LGI1
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
2.15mM MES, 47.35mM phosphate with 1.033mM EDTA and no preservative; pH 7.4
Gene Accession No.:
O95970, Q8K4Y5, Q9JIA1
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
252892, 56839, 9211
Content And Storage:
4° C
Isotype:
IgG2a
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
S283-7
Conjugate:
PE
Gene:
LGI1
Gene Symbols:
LGI1
Immunogen:
Fusion protein amino acids 37-113 (LRRNT domain and first LRR repeat) of mouse LGI1.
Quantity:
100 μg
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid