PIMA547090
MCL-1 Recombinant Rabbit Monoclonal Antibody (HL1544), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547090-Each-of-1 | In Stock | ₹ 38,758.68 |
PIMA547090 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,758.68
GST (18%): ₹ 6,976.562
Total Price: ₹ 45,735.242
Antigen
MCL-1
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with no preservative
Gene Accession No.
P97287, Q07820, Q9Z1P3
Gene Symbols
MCL1
Immunogen
Recombinant protein encompassing a sequence within the center region of human MCL1. The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
HL1544
Conjugate
Unconjugated
Gene
MCL1
Gene Alias
AW556805; BCL2 family apoptosis regulator; BCL2L3; bcl2-L-3; Bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Mcl1; Mcl-1; mcl1/EAT; MCL1-ES; MCL1L; MCL1S; MCL-1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1; myeloid cell leukemia sequence 1 (BCL2-related); TM
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
17210, 4170, 60430
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Store as concentrated solution
- Centrifuge briefly prior to opening vial
- MCL1 (Myeloid cell leukemia-1) belongs to the Bcl-2 family and is involved in programing, differentiation and concomitant maintenance of cell viability, but not of proliferation
- Isoform 1 of MCL1 inhibits apoptosis while isoform 2 promotes it
- The carboxy terminal of MCL1 and bcl-2 share significant sequence homology
- Expression of MCL1 is increased upon exposure of ML-1 cells to various types of DNA damaging agents (e.g
- ionizing radiation, μgtraviolet radiation, and alkylating drugs) along with increases in GADD45 and Bax and a decrease in bcl-2
- Enhanced expression of MCL1, prominently associated with mitochondria, complements the continued expression of bcl-2 in ML-1 cells undergoing differentiation
- Like bcl-2, MCL1 has the capacity to promote cell viability under conditions that otherwise cause apoptosis
- While the mechanism by which MCL1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak
- MCL1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types
- MCL1 is essential for embryogenesis and for the development and maintenance of B and T lymphocytes in animals
- MCL1 exists as at least two distinct isoforms designated MCL1L and MCL1S
- In marked contrast to the larger isoform of MCL1, overexpression of MCL1S promotes cell death.
Compare Similar Items
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Antigen: MCL-1
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P97287, Q07820, Q9Z1P3
Gene Symbols: MCL1
Immunogen: Recombinant protein encompassing a sequence within the center region of human MCL1. The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: HL1544
Conjugate: Unconjugated
Gene: MCL1
Gene Alias: AW556805; BCL2 family apoptosis regulator; BCL2L3; bcl2-L-3; Bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Mcl1; Mcl-1; mcl1/EAT; MCL1-ES; MCL1L; MCL1S; MCL-1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1; myeloid cell leukemia sequence 1 (BCL2-related); TM
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 17210, 4170, 60430
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
MCL-1
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P97287, Q07820, Q9Z1P3
Gene Symbols:
MCL1
Immunogen:
Recombinant protein encompassing a sequence within the center region of human MCL1. The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
HL1544
Conjugate:
Unconjugated
Gene:
MCL1
Gene Alias:
AW556805; BCL2 family apoptosis regulator; BCL2L3; bcl2-L-3; Bcl-2-like protein 3; bcl-2-related protein EAT/mcl1; EAT; Induced myeloid leukemia cell differentiation protein Mcl-1; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; Mcl1; Mcl-1; mcl1/EAT; MCL1-ES; MCL1L; MCL1S; MCL-1S; MGC104264; MGC1839; myeloid cell leukemia 1; myeloid cell leukemia ES; myeloid cell leukemia sequence 1; myeloid cell leukemia sequence 1 (BCL2-related); TM
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
17210, 4170, 60430
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: Influenza A H10N3 HA (A/Jiangsu/428/2021)
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: __
Gene Symbols: __
Immunogen: Recombinant protein encompassing a sequence within the center region of Influenza A virus H10N3 HA (Hemagglutinin)(A/Jiangsu/428/2021 (H10N3)). The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Virus
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone: HL1559
Conjugate: Unconjugated
Gene: __
Gene Alias: flu hemagglutinin; influenza hemagglutinin
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): __
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Influenza A H10N3 HA (A/Jiangsu/428/2021)
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
__
Gene Symbols:
__
Immunogen:
Recombinant protein encompassing a sequence within the center region of Influenza A virus H10N3 HA (Hemagglutinin)(A/Jiangsu/428/2021 (H10N3)). The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Virus
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone:
HL1559
Conjugate:
Unconjugated
Gene:
__
Gene Alias:
flu hemagglutinin; influenza hemagglutinin
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
__
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: GRK2
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P25098, P26817, Q99MK8
Gene Symbols: GRK2
Immunogen: Recombinant protein encompassing a sequence within the C-terminus region of human GRK2. The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: HL1562
Conjugate: Unconjugated
Gene: GRK2
Gene Alias: ADRBK1; Adrbk-1; adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; BARK; BARK1; Bark-1; beta ARK; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; betaARK1; BETA-ARK1; beta-ARK-1; EC 2.7.1.126; G protein-coupled receptor kinase 2; G-protein coupled receptor kinase 2; G-protein-coupled receptor kinase 2; grk 2; Grk2; GRK-2
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 110355, 156, 25238
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
GRK2
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P25098, P26817, Q99MK8
Gene Symbols:
GRK2
Immunogen:
Recombinant protein encompassing a sequence within the C-terminus region of human GRK2. The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
HL1562
Conjugate:
Unconjugated
Gene:
GRK2
Gene Alias:
ADRBK1; Adrbk-1; adrenergic beta receptor kinase 1; adrenergic receptor kinase, beta 1; adrenergic, beta, receptor kinase 1; BARK; BARK1; Bark-1; beta ARK; Beta-adrenergic receptor kinase 1; beta-adrenergic receptor kinase 1 beta ARK1; beta-AR kinase-1; betaARK1; BETA-ARK1; beta-ARK-1; EC 2.7.1.126; G protein-coupled receptor kinase 2; G-protein coupled receptor kinase 2; G-protein-coupled receptor kinase 2; grk 2; Grk2; GRK-2
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
110355, 156, 25238
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: ADAM17
Classification: Monoclonal
Concentration: 2 mg/mL
Formulation: PBS with no preservative
Gene Accession No.: P78536, Q9Z0F8
Gene Symbols: ADAM17
Immunogen: Recombinant protein encompassing a sequence within the center region of human ADAM17. The exact sequence is proprietary.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: HL1572
Conjugate: Unconjugated
Gene: ADAM17
Gene Alias: a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADAM; ADAM 17; ADAM metallopeptidase domain 17; ADAM metallopeptidase domain 18; Adam17; ADAM18; ADAMs; CD156B; CD156b antigen; CSVP; Disintegrin and metalloproteinase domain-containing protein 17; metalloendopeptidases; NISBD; NISBD1; Snake venom-like protease; TACE; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; tumor necrosis factor, alpha, converting enzyme
Host Species: Rabbit
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 11491, 6868
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
ADAM17
Classification:
Monoclonal
Concentration:
2 mg/mL
Formulation:
PBS with no preservative
Gene Accession No.:
P78536, Q9Z0F8
Gene Symbols:
ADAM17
Immunogen:
Recombinant protein encompassing a sequence within the center region of human ADAM17. The exact sequence is proprietary.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
HL1572
Conjugate:
Unconjugated
Gene:
ADAM17
Gene Alias:
a disintegrin and metallopeptidase domain 17; a disintegrin and metalloprotease domain 17; a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 17; a disintegrin and metalloproteinase domain 17 (tumor necrosis factor, alpha, converting enzyme); ADAM; ADAM 17; ADAM metallopeptidase domain 17; ADAM metallopeptidase domain 18; Adam17; ADAM18; ADAMs; CD156B; CD156b antigen; CSVP; Disintegrin and metalloproteinase domain-containing protein 17; metalloendopeptidases; NISBD; NISBD1; Snake venom-like protease; TACE; TNF-alpha convertase; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; tumor necrosis factor, alpha, converting enzyme
Host Species:
Rabbit
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
11491, 6868
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid