PIMA547326
Aurora A/B/C Monoclonal Antibody (4A7), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547326-Each-of-1 | In Stock | ₹ 1,43,740.80 |
PIMA547326 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 1,43,740.80
GST (18%): ₹ 25,873.344
Total Price: ₹ 1,69,614.144
Antigen
Aurora A/B/C
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 5mM sodium azide
Gene Accession No.
A5GFW1, O14965, O55099, O70126, O88445, P59241, P97477, Q2TA06, Q7YRC6, Q96GD4, Q9N0X0, Q9UQB9
Gene Symbols
Aurka, Aurkb, AURKC
Immunogen
Full length recombinant human AURKA protein expressed from E. coli.
Quantity
500 μL
Primary or Secondary
Primary
Target Species
Bovine, Equine, Human, Mouse, Porcine, Rat
Product Type
Antibody
Isotype
IgG1
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
4A7
Conjugate
Unconjugated
Gene
Aurka
Gene Alias
Aik; Aik2; AIM1; AIM-1; Airk; AIRK1; AIRK2; AL022959; ARK1; ARK-1; ARK2; ARK-2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora 2; aurora A; aurora- and Ipl1-like midbody-associated protein 1; aurora B; aurora family kinase 1; Aurora kinase A; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; AW539821; Ayk1; Breast tumor-amplified kinase; Btak; IAK; IAK1; IPL1; ipl1- and aurora-related kinase 1; PPP1R47; PPP1R48; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; serine/threonine-prot
Host Species
Mouse
Purification Method
Protein A/G
Regulatory Status
RUO
Gene ID (Entrez)
100050161, 100051177, 100073050, 110261316, 114592, 20871, 20877, 20878, 261730, 292554, 360192, 396955, 504437, 574063, 618599, 6790, 6795, 9212
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis
- The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly
- Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis
- Required for central/midzone spindle assembly and cleavage furrow formation
- Key component of the cytokinesis checkpoint, a process required to delay abscission to prevent both premature resolution of intercellular chromosome bridges and accumulation of DNA damage: phosphorylates CHMP4C, leading to retain abscission-competent VPS4 (VPS4A and/or VPS4B) at the midbody ring until abscission checkpoint signaling is terminated at late cytokinesis (PubMed:22422861, PubMed:24814515)
- AURKB phosphorylates the CPC complex subunits BIRC5/survivin, CDCA8/borealin and INCENP
- Phosphorylation of INCENP leads to increased AURKB activity
- Other known AURKB substrates involved in centromeric functions and mitosis are CENPA, DES/desmin, GPAF, KIF2C, NSUN2, RACGAP1, SEPT1, VIM/vimentin, GSG2/Haspin, and histone H3
- A positive feedback loop involving GSG2 and AURKB contributes to localization of CPC to centromeres
- Phosphorylation of VIM controls vimentin filament segregation in cytokinetic process, whereas histone H3 is phosphorylated at 'Ser-10' and 'Ser-28' during mitosis (H3S10ph and H3S28ph, respectively)
- A positive feedback between GSG2 and AURKB contributes to CPC localization
- AURKB is also required for kinetochore localization of BUB1 and SGOL1
- Phosphorylation of p53/TP53 negatively regulates its transcriptional activity
- Key regulator of active promoters in resting B- and T-lymphocytes.
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Antigen: Aurora A/B/C
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 5mM sodium azide
Gene Accession No.: A5GFW1, O14965, O55099, O70126, O88445, P59241, P97477, Q2TA06, Q7YRC6, Q96GD4, Q9N0X0, Q9UQB9
Gene Symbols: Aurka, Aurkb, AURKC
Immunogen: Full length recombinant human AURKA protein expressed from E. coli.
Quantity: 500 μL
Primary or Secondary: Primary
Target Species: Bovine, Equine, Human, Mouse, Porcine, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: 4A7
Conjugate: Unconjugated
Gene: Aurka
Gene Alias: Aik; Aik2; AIM1; AIM-1; Airk; AIRK1; AIRK2; AL022959; ARK1; ARK-1; ARK2; ARK-2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora 2; aurora A; aurora- and Ipl1-like midbody-associated protein 1; aurora B; aurora family kinase 1; Aurora kinase A; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; AW539821; Ayk1; Breast tumor-amplified kinase; Btak; IAK; IAK1; IPL1; ipl1- and aurora-related kinase 1; PPP1R47; PPP1R48; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; serine/threonine-prot
Host Species: Mouse
Purification Method: Protein A/G
Regulatory Status: RUO
Gene ID (Entrez): 100050161, 100051177, 100073050, 110261316, 114592, 20871, 20877, 20878, 261730, 292554, 360192, 396955, 504437, 574063, 618599, 6790, 6795, 9212
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Aurora A/B/C
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 5mM sodium azide
Gene Accession No.:
A5GFW1, O14965, O55099, O70126, O88445, P59241, P97477, Q2TA06, Q7YRC6, Q96GD4, Q9N0X0, Q9UQB9
Gene Symbols:
Aurka, Aurkb, AURKC
Immunogen:
Full length recombinant human AURKA protein expressed from E. coli.
Quantity:
500 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Equine, Human, Mouse, Porcine, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
4A7
Conjugate:
Unconjugated
Gene:
Aurka
Gene Alias:
Aik; Aik2; AIM1; AIM-1; Airk; AIRK1; AIRK2; AL022959; ARK1; ARK-1; ARK2; ARK-2; AU019385; AURA; AurB; AURKA; AURKB; aurkb-sv1; aurkb-sv2; Aurora 1; aurora 2; aurora A; aurora- and Ipl1-like midbody-associated protein 1; aurora B; aurora family kinase 1; Aurora kinase A; aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora/IPL1-like kinase; aurora/IPL1-related kinase 1; Aurora/IPL1-related kinase 2; aurora-1; aurora-A; aurora-B; aurora-related kinase 1; aurora-related kinase 2; AW539821; Ayk1; Breast tumor-amplified kinase; Btak; IAK; IAK1; IPL1; ipl1- and aurora-related kinase 1; PPP1R47; PPP1R48; protein phosphatase 1, regulatory subunit 47; protein phosphatase 1, regulatory subunit 48; ratAurA; serine/threonine kinase 12; serine/threonine kinase 5; serine/threonine kinase 6; serine/threonine protein kinase 15; serine/threonine protein kinase 6; serine/threonine-protein kinase 12; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 5; serine/threonine-prot
Host Species:
Mouse
Purification Method:
Protein A/G
Regulatory Status:
RUO
Gene ID (Entrez):
100050161, 100051177, 100073050, 110261316, 114592, 20871, 20877, 20878, 261730, 292554, 360192, 396955, 504437, 574063, 618599, 6790, 6795, 9212
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: Aldolase C
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 5mM sodium azide
Gene Accession No.: P05063, P09117, P09972
Gene Symbols: ALDOC
Immunogen: N-terminal sequence MPHSYPALSAEQKKELSDIA
Quantity: 500 μL
Primary or Secondary: Primary
Target Species: Bovine, Human, Mouse, Porcine, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: 4A9
Conjugate: Unconjugated
Gene: ALDOC
Gene Alias: AI847350; ALDC; ALDCAA; Aldo3; ALDOC; Aldolase 3; aldolase C, fructose-biphosphate; aldolase C, fructose-bisphosphate; aldolase, fructose-bisphosphate C; AU040929; Brain-type aldolase; EC 4.1.2.13; F16dip7; fructoaldolase C; fructose-1,6-biphosphate triosephosphate lyase; fructose-bisphosphate aldolase C; RATALDCAA; Scrapie-responsive protein 2; Scrg2; Zebrin II
Host Species: Mouse
Purification Method: Protein A/G
Regulatory Status: RUO
Gene ID (Entrez): 100512013, 11676, 230, 24191, 504584
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Aldolase C
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 5mM sodium azide
Gene Accession No.:
P05063, P09117, P09972
Gene Symbols:
ALDOC
Immunogen:
N-terminal sequence MPHSYPALSAEQKKELSDIA
Quantity:
500 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Human, Mouse, Porcine, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
4A9
Conjugate:
Unconjugated
Gene:
ALDOC
Gene Alias:
AI847350; ALDC; ALDCAA; Aldo3; ALDOC; Aldolase 3; aldolase C, fructose-biphosphate; aldolase C, fructose-bisphosphate; aldolase, fructose-bisphosphate C; AU040929; Brain-type aldolase; EC 4.1.2.13; F16dip7; fructoaldolase C; fructose-1,6-biphosphate triosephosphate lyase; fructose-bisphosphate aldolase C; RATALDCAA; Scrapie-responsive protein 2; Scrg2; Zebrin II
Host Species:
Mouse
Purification Method:
Protein A/G
Regulatory Status:
RUO
Gene ID (Entrez):
100512013, 11676, 230, 24191, 504584
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: Nestin
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 5mM sodium azide
Gene Accession No.: P21263, P48681, Q6P5H2
Gene Symbols: Nes
Immunogen: Recombinant construct, amino acids 317-630 of the human protein expressed in and purified from E. coli.
Quantity: 500 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: 4D11
Conjugate: Unconjugated
Gene: Nes
Gene Alias: AA166324; C78523; ESTM46; FLJ21841; intermediate filament protein; Nbla00170; Nes; Nestin
Host Species: Mouse
Purification Method: Protein A/G
Regulatory Status: RUO
Gene ID (Entrez): 10763, 18008, 25491
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
Nestin
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 5mM sodium azide
Gene Accession No.:
P21263, P48681, Q6P5H2
Gene Symbols:
Nes
Immunogen:
Recombinant construct, amino acids 317-630 of the human protein expressed in and purified from E. coli.
Quantity:
500 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
4D11
Conjugate:
Unconjugated
Gene:
Nes
Gene Alias:
AA166324; C78523; ESTM46; FLJ21841; intermediate filament protein; Nbla00170; Nes; Nestin
Host Species:
Mouse
Purification Method:
Protein A/G
Regulatory Status:
RUO
Gene ID (Entrez):
10763, 18008, 25491
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid
Antigen: PEA15
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 50% glycerol and 5mM sodium azide
Gene Accession No.: Q15121, Q5U318, Q62048
Gene Symbols: PEA15, Pea15a
Immunogen: Full length human PEA-15 as expressed in and purified from E. coli.
Quantity: 500 μL
Primary or Secondary: Primary
Target Species: Bovine, Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG1
Applications: Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
Clone: 4D117
Conjugate: Unconjugated
Gene: PEA15
Gene Alias: 15 kDa phosphoprotein enriched in astrocytes; astrocytic phosphoprotein PEA-15; HMAT1; homolog of mouse MAT-1 oncogene; HUMMAT1H; mammary transforming gene 1; mammary transforming gene 1, mouse, homolog of; MAT1; MAT1H; OTTHUMP00000029887; Pea15; PEA-15; Pea15a; PED; phosphoprotein enriched in astrocytes 15; phosphoprotein enriched in astrocytes 15A; phosphoprotein enriched in diabetes; Pkcs15; proliferation and apoptosis adaptor protein 15
Host Species: Mouse
Purification Method: Protein A/G
Regulatory Status: RUO
Gene ID (Entrez): 18611, 364052, 510586, 8682
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form: Liquid
Antigen:
PEA15
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 50% glycerol and 5mM sodium azide
Gene Accession No.:
Q15121, Q5U318, Q62048
Gene Symbols:
PEA15, Pea15a
Immunogen:
Full length human PEA-15 as expressed in and purified from E. coli.
Quantity:
500 μL
Primary or Secondary:
Primary
Target Species:
Bovine, Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunohistochemistry (PFA fixed), Western Blot
Clone:
4D117
Conjugate:
Unconjugated
Gene:
PEA15
Gene Alias:
15 kDa phosphoprotein enriched in astrocytes; astrocytic phosphoprotein PEA-15; HMAT1; homolog of mouse MAT-1 oncogene; HUMMAT1H; mammary transforming gene 1; mammary transforming gene 1, mouse, homolog of; MAT1; MAT1H; OTTHUMP00000029887; Pea15; PEA-15; Pea15a; PED; phosphoprotein enriched in astrocytes 15; phosphoprotein enriched in astrocytes 15A; phosphoprotein enriched in diabetes; Pkcs15; proliferation and apoptosis adaptor protein 15
Host Species:
Mouse
Purification Method:
Protein A/G
Regulatory Status:
RUO
Gene ID (Entrez):
18611, 364052, 510586, 8682
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form:
Liquid