PIMA547626
Phospho-FAK (Tyr397) Monoclonal Antibody (M121), Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547626-Each-of-1 | In Stock | ₹ 44,961.78 |
PIMA547626 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,961.78
GST (18%): ₹ 8,093.12
Total Price: ₹ 53,054.90
Antigen
Phospho-FAK (Tyr397)
Classification
Monoclonal
Concentration
Lot-Specific
Formulation
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.
O35346, P34152, Q05397
Gene Symbols
PTK2
Immunogen
Clone (M121) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 397 of human FAK. This peptide sequence has high homology to the conserved tyrosine site in rat and mouse FAK.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Western Blot
Clone
M121
Conjugate
Unconjugated
Gene
PTK2
Gene Alias
CG10023; CG10023-PA; CG10023-PB; CG10023-PC; CG10023-PD; CG10023-PF; CG10023-PG; CT28129; DFAK; DFak56; Dmel\CG10023; Dmel_CG10023; DmFAK; EC 2.7.10.2; Fadk; FADK 1; Fak; Fak1; Fak56; fak56D; FAK65D; Fak-PA; Fak-PB; Fak-PC; Fak-PD; Fak-PF; Fak-PG; FAK-related non-kinase polypeptide; focal adhesion kinase; Focal adhesion kinase 1; focal adhesion kinase homolog; focal adhesion kinase isoform FAK-Del33; focal adhesion kinase pp125FAK; focal adhesion kinase-related nonkinase; focal ashension kinase 1; FRNK; I79_019430; Kiaa4203; mKIAA4203; p125FAK; p41/p43FRNK; pFAK; pp125 PTK2; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; protein tyrosine kinase 2; protein tyrosine kinase 2 L homeolog; protein-tyrosine kinase; protein-tyrosine kinase 2; PTK2; PTK2 protein tyrosine kinase 2; ptk2.L; tyrosine kinase; XELAEV_18032408mg; XPFAK
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
14083, 25614, 5747
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG1
Description
- The antibody detects a 125 kDa* protein on SDS-PAGE immunoblots of untreated HUVEC cells
- This phosphorylated band is greatly reduced after treatment with alkaline phosphatase
- Focal Adhesion Kinase (FAK) is a 125 kDa non-receptor protein tyrosine kinase that acts as a substrate for Src and is a key element of integrin signaling
- FAK plays an important role in cell spreading, differentiation, migration, cell death, and acceleration of the G1 to S phase transition of the cell cycle
- FAK has a central catalytic domain and a C-terminal tail that localizes it to focal adhesions, which are sites where cells attach to the extracellular matrix via surface integrin receptors
- Increased FAK tyrosine phosphorylation occurs upon integrin engagement with fibronectin
- Adhesion of murine NIH3T3 fibroblasts to fibronectin promotes association of the Grb2 adapter protein and c-Src PTK with FAK in vivo, and also results in activation of the ERK2 MAP kinase
- In v-Src-transformed NIH3T3, the association of v-Src, Grb2, and Sos with FAK is independent of cell adhesion to fibronectin
- In vitro the Grb2 SH2 domain binds directly to tyrosine-phosphorylated FAK, and the binding site has been identified as Tyr925 by site directed mutagenesis
- Several transcript variants encoding different isoforms have been found for the FAK gene, but the full-length natures of only three of them have been determined.
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Antigen: Phospho-FAK (Tyr397)
Classification: Monoclonal
Concentration: Lot-Specific
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: O35346, P34152, Q05397
Gene Symbols: PTK2
Immunogen: Clone (M121) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 397 of human FAK. This peptide sequence has high homology to the conserved tyrosine site in rat and mouse FAK.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Western Blot
Clone: M121
Conjugate: Unconjugated
Gene: PTK2
Gene Alias: CG10023; CG10023-PA; CG10023-PB; CG10023-PC; CG10023-PD; CG10023-PF; CG10023-PG; CT28129; DFAK; DFak56; Dmel\CG10023; Dmel_CG10023; DmFAK; EC 2.7.10.2; Fadk; FADK 1; Fak; Fak1; Fak56; fak56D; FAK65D; Fak-PA; Fak-PB; Fak-PC; Fak-PD; Fak-PF; Fak-PG; FAK-related non-kinase polypeptide; focal adhesion kinase; Focal adhesion kinase 1; focal adhesion kinase homolog; focal adhesion kinase isoform FAK-Del33; focal adhesion kinase pp125FAK; focal adhesion kinase-related nonkinase; focal ashension kinase 1; FRNK; I79_019430; Kiaa4203; mKIAA4203; p125FAK; p41/p43FRNK; pFAK; pp125 PTK2; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; protein tyrosine kinase 2; protein tyrosine kinase 2 L homeolog; protein-tyrosine kinase; protein-tyrosine kinase 2; PTK2; PTK2 protein tyrosine kinase 2; ptk2.L; tyrosine kinase; XELAEV_18032408mg; XPFAK
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 14083, 25614, 5747
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG1
Antigen:
Phospho-FAK (Tyr397)
Classification:
Monoclonal
Concentration:
Lot-Specific
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
O35346, P34152, Q05397
Gene Symbols:
PTK2
Immunogen:
Clone (M121) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 397 of human FAK. This peptide sequence has high homology to the conserved tyrosine site in rat and mouse FAK.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Western Blot
Clone:
M121
Conjugate:
Unconjugated
Gene:
PTK2
Gene Alias:
CG10023; CG10023-PA; CG10023-PB; CG10023-PC; CG10023-PD; CG10023-PF; CG10023-PG; CT28129; DFAK; DFak56; Dmel\CG10023; Dmel_CG10023; DmFAK; EC 2.7.10.2; Fadk; FADK 1; Fak; Fak1; Fak56; fak56D; FAK65D; Fak-PA; Fak-PB; Fak-PC; Fak-PD; Fak-PF; Fak-PG; FAK-related non-kinase polypeptide; focal adhesion kinase; Focal adhesion kinase 1; focal adhesion kinase homolog; focal adhesion kinase isoform FAK-Del33; focal adhesion kinase pp125FAK; focal adhesion kinase-related nonkinase; focal ashension kinase 1; FRNK; I79_019430; Kiaa4203; mKIAA4203; p125FAK; p41/p43FRNK; pFAK; pp125 PTK2; pp125FAK; PPP1R71; Protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; protein tyrosine kinase 2; protein tyrosine kinase 2 L homeolog; protein-tyrosine kinase; protein-tyrosine kinase 2; PTK2; PTK2 protein tyrosine kinase 2; ptk2.L; tyrosine kinase; XELAEV_18032408mg; XPFAK
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
14083, 25614, 5747
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG1
Antigen: Phospho-Fascin (Ser39)
Classification: Monoclonal
Concentration: Lot-Specific
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: P85845, Q16658, Q61553
Gene Symbols: FSCN1
Immunogen: Clone (M315) was generated from a phospho-Fascin (Ser39) synthetic peptide (coupled to carrier peptide) corresponding to amino acids surrounding Ser39 in human Fascin. This sequence has high homology to the conserved site in rat and mouse Fascin, as well as to the conserved region in Fascin 2, but low homology to the conserved region in Fascin 3.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: M315
Conjugate: Unconjugated
Gene: FSCN1
Gene Alias: 55 kDa actin-bundling protein; 55kDa actin-bundling protein; AI663989; Fan1; fascin; fascin 1; fascin actin-bundling protein 1; Fascin homolog 1; fascin homolog 1, actin bundling protein; fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus); fascin homolog 1, actin-bundling protein; Fascin1; fascin-1; Fscn1; fscn1 {ECO:0000250; HSN; p55; Singed; Singed (Drosophila) like (sea urchin fascin homolog like); singed-like (fascin homolog, sea urchin); singed-like protein; SNL; UniProtKB:Q16658}
Host Species: Mouse
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 14086, 6624, 683788
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG1
Antigen:
Phospho-Fascin (Ser39)
Classification:
Monoclonal
Concentration:
Lot-Specific
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P85845, Q16658, Q61553
Gene Symbols:
FSCN1
Immunogen:
Clone (M315) was generated from a phospho-Fascin (Ser39) synthetic peptide (coupled to carrier peptide) corresponding to amino acids surrounding Ser39 in human Fascin. This sequence has high homology to the conserved site in rat and mouse Fascin, as well as to the conserved region in Fascin 2, but low homology to the conserved region in Fascin 3.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
M315
Conjugate:
Unconjugated
Gene:
FSCN1
Gene Alias:
55 kDa actin-bundling protein; 55kDa actin-bundling protein; AI663989; Fan1; fascin; fascin 1; fascin actin-bundling protein 1; Fascin homolog 1; fascin homolog 1, actin bundling protein; fascin homolog 1, actin bundling protein (Strongylocentrotus purpuratus); fascin homolog 1, actin-bundling protein; Fascin1; fascin-1; Fscn1; fscn1 {ECO:0000250; HSN; p55; Singed; Singed (Drosophila) like (sea urchin fascin homolog like); singed-like (fascin homolog, sea urchin); singed-like protein; SNL; UniProtKB:Q16658}
Host Species:
Mouse
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
14086, 6624, 683788
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG1
Antigen: Phospho-GSK3 alpha/beta (Tyr279, Tyr216)
Classification: Monoclonal
Concentration: 0.25 mg/mL
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: P18265, P18266, P49840, P49841, Q2NL51, Q9WV60
Gene Symbols: GSK3A, GSK3B
Immunogen: Clone M132 was generated from a phospho-GSK-3beta (Tyr-216) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 216 of human GSK-3beta. This peptide sequence is also found in GSK-3alpha (Tyr-279) and is highly conserved in GSK-3 genes in rat and mouse.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Western Blot
Clone: M132
Conjugate: Unconjugated
Gene: GSK3B
Gene Alias: 2700086H06Rik; 7330414F15Rik; 8430431H08Rik; C86142; FA; factor A; glycogen synthase kinase 3 alpha; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 alpha; Glycogen synthase kinase-3 beta; GSK3; GSK-3; GSK-3 alpha; GSK-3 beta; Gsk3a; gsk-3-alpha; Gsk3b; GSK-3beta; GSK3beta isoform; serine/threonine-protein kinase GSK3A; Serine/threonine-protein kinase GSK3B
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 2931, 2932, 50686, 56637, 606496, 84027
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG1
Antigen:
Phospho-GSK3 alpha/beta (Tyr279, Tyr216)
Classification:
Monoclonal
Concentration:
0.25 mg/mL
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P18265, P18266, P49840, P49841, Q2NL51, Q9WV60
Gene Symbols:
GSK3A, GSK3B
Immunogen:
Clone M132 was generated from a phospho-GSK-3beta (Tyr-216) synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 216 of human GSK-3beta. This peptide sequence is also found in GSK-3alpha (Tyr-279) and is highly conserved in GSK-3 genes in rat and mouse.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Western Blot
Clone:
M132
Conjugate:
Unconjugated
Gene:
GSK3B
Gene Alias:
2700086H06Rik; 7330414F15Rik; 8430431H08Rik; C86142; FA; factor A; glycogen synthase kinase 3 alpha; glycogen synthase kinase 3 beta; glycogen synthase kinase-3 alpha; Glycogen synthase kinase-3 beta; GSK3; GSK-3; GSK-3 alpha; GSK-3 beta; Gsk3a; gsk-3-alpha; Gsk3b; GSK-3beta; GSK3beta isoform; serine/threonine-protein kinase GSK3A; Serine/threonine-protein kinase GSK3B
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
2931, 2932, 50686, 56637, 606496, 84027
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG1
Antigen: Phospho-IkB alpha (Ser32, Ser36)
Classification: Monoclonal
Concentration: Lot-Specific
Formulation: PBS with 0.5% BSA and 0.05% sodium azide
Gene Accession No.: P25963, Q63746, Q9Z1E3
Gene Symbols: NFKBIA
Immunogen: Clone 39A1413 was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues around serine 32 and 36 of human IkappaBalpha. This peptide sequence is highly conserved in mouse, rat, dog, cow, and pig IkappaBalpha.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Immunoprecipitation, Western Blot
Clone: 39A1413
Conjugate: Unconjugated
Gene: NFKBIA
Gene Alias: AI462015; ECI-6; ECI-6/IKBA; I kappa B-alpha; I(Kappa)B(alpha); I79_018146; IkappaB alpha; IkappaBalpha; I-kappaBalpha; I-kappa-B-alpha; Ikba; IKBalpha; IKB-alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha; MAD3; MAD-3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappaB inhibitor alpha; NF-kappa-B inhibitor alpha; NFKB inhibitor alpha; NFKBI; Nfkbia; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polyp gene enhancer in B-cell 1; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Rel-associated pp40; REL-associated protein pp40; RL/IF-1
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 18035, 25493, 4792
Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype: IgG1
Antigen:
Phospho-IkB alpha (Ser32, Ser36)
Classification:
Monoclonal
Concentration:
Lot-Specific
Formulation:
PBS with 0.5% BSA and 0.05% sodium azide
Gene Accession No.:
P25963, Q63746, Q9Z1E3
Gene Symbols:
NFKBIA
Immunogen:
Clone 39A1413 was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues around serine 32 and 36 of human IkappaBalpha. This peptide sequence is highly conserved in mouse, rat, dog, cow, and pig IkappaBalpha.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot
Clone:
39A1413
Conjugate:
Unconjugated
Gene:
NFKBIA
Gene Alias:
AI462015; ECI-6; ECI-6/IKBA; I kappa B-alpha; I(Kappa)B(alpha); I79_018146; IkappaB alpha; IkappaBalpha; I-kappaBalpha; I-kappa-B-alpha; Ikba; IKBalpha; IKB-alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells alpha; Inhibitor of nuclear factor of kappa light chain gene enhancer in B-cells, alpha; MAD3; MAD-3; Major histocompatibility complex enhancer-binding protein MAD3; NF kappa B inhibitor alpha; NF-kappaB inhibitor alpha; NF-kappa-B inhibitor alpha; NFKB inhibitor alpha; NFKBI; Nfkbia; nuclear factor of kappa light chain gene enhancer in B-cells; nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha; nuclear factor of kappa light polyp gene enhancer in B-cell 1; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha; Rel-associated pp40; REL-associated protein pp40; RL/IF-1
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
18035, 25493, 4792
Content And Storage:
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype:
IgG1