PIMA547737
SPHK2 Monoclonal Antibody (M532), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA547737-Each-of-1 | In Stock | ₹ 44,961.78 |
PIMA547737 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,961.78
GST (18%): ₹ 8,093.12
Total Price: ₹ 53,054.90
Antigen
SPHK2
Classification
Monoclonal
Concentration
∽1.0 mg/mL
Formulation
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.
Q9JIA7, Q9NRA0
Gene Symbols
Sphk2
Immunogen
Clone M532 was generated from a SK2 (N-terminal region) synthetic peptide (coupled to KLH) corresponding to amino acid residues in the N-terminal region of human SK2. This peptide sequence is highly conserved in rat and mouse SK2 proteins, and has no homology to SK1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Applications
Western Blot
Clone
M532
Conjugate
Unconjugated
Gene
Sphk2
Gene Alias
C76851; SK 2; SK2; SK-2; Sphingosine kinase 2; sphingosine kinase type 2; Sphk2; SPK 2; SPK-2; Spk2, Sk2
Host Species
Mouse
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
308589, 56632, 56848
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG1
Description
- The antibody detects 70 kDa* proteins corresponding to the molecular mass of SK2 on SDS-PAGE immunoblots of human recombinant SK2 and endogenous SK2 in human HeLa cells
- SPHK2, along with SPHK1, catalyzes the phosphorylation of sphingosine producing the signaling molecule sphingosine-1-phosphate (S1P)
- S1P signals through G-protein coupled receptors and controls diverse cellular processes
- Inhibitors of SPHKs are viewed as potential therapeutics for the treatment of cancer
- SPHK2 is an important signaling molecule with intra- and extracellular functions and has been implicated in regulating cell differentiation, calcium mobilization from intracellular stores, and apoptosis
- The cell surface receptors for S1P are the EDG family of G protein-coupled receptors (S1P Receptors)
- These receptors couple to multiple G proteins (e.g
- S1P1 couples to Gi whereas S1P2 and S1P3 couple to Gq, G13 in addition to Gi) and regulate a extremely wide raange of cellular events including cell motility, survival, apoptosis, migration and cell-cell interaction
- Important roles for S1P have also been reported in regulation of cardiogenesis, vascular maturation, oocyte survival, immune cell trafficking, cells of the neuronal system and bone cells
- S1P levels are regulated by the activity of Sphk (Sphk1 and Sphk2).
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Antigen: SPHK2
Classification: Monoclonal
Concentration: ∽1.0 mg/mL
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: Q9JIA7, Q9NRA0
Gene Symbols: Sphk2
Immunogen: Clone M532 was generated from a SK2 (N-terminal region) synthetic peptide (coupled to KLH) corresponding to amino acid residues in the N-terminal region of human SK2. This peptide sequence is highly conserved in rat and mouse SK2 proteins, and has no homology to SK1.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Western Blot
Clone: M532
Conjugate: Unconjugated
Gene: Sphk2
Gene Alias: C76851; SK 2; SK2; SK-2; Sphingosine kinase 2; sphingosine kinase type 2; Sphk2; SPK 2; SPK-2; Spk2, Sk2
Host Species: Mouse
Purification Method: Protein G
Regulatory Status: RUO
Gene ID (Entrez): 308589, 56632, 56848
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG1
Antigen:
SPHK2
Classification:
Monoclonal
Concentration:
∽1.0 mg/mL
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
Q9JIA7, Q9NRA0
Gene Symbols:
Sphk2
Immunogen:
Clone M532 was generated from a SK2 (N-terminal region) synthetic peptide (coupled to KLH) corresponding to amino acid residues in the N-terminal region of human SK2. This peptide sequence is highly conserved in rat and mouse SK2 proteins, and has no homology to SK1.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Western Blot
Clone:
M532
Conjugate:
Unconjugated
Gene:
Sphk2
Gene Alias:
C76851; SK 2; SK2; SK-2; Sphingosine kinase 2; sphingosine kinase type 2; Sphk2; SPK 2; SPK-2; Spk2, Sk2
Host Species:
Mouse
Purification Method:
Protein G
Regulatory Status:
RUO
Gene ID (Entrez):
308589, 56632, 56848
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG1
Antigen: SRC
Classification: Monoclonal
Concentration: Lot-Specific
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: P05480, P12931, Q9WUD9
Gene Symbols: SRC
Immunogen: Clone (M259) was generated from a recombinant protein containing amino acids in the N-terminal region of human c-Src. This sequence has high homology to similar regions in rat and mouse c-Src.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Immunoprecipitation, Western Blot
Clone: M259
Conjugate: Unconjugated
Gene: SRC
Gene Alias: ASV; AW259666; csrc; c-SRC; c-src protein, C terminus; EC 2.7.10.2; fc54g04; Neuronal proto-oncogene tyrosine-protein kinase Src; non-tyrosine protein kinase; ORF; OTTHUMP00000174476; OTTHUMP00000174477; OTTHUMP00000174478; p60-Src; p60-Src-1; PP60C-SCR; pp60c-src; pp60src; pp60v-src; protein-tyrosine kinase; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; Proto-oncogene tyrosine-protein kinase Src; Rous sarcoma oncogene; RP5-823N20.1; sb:cb864; SDR; src; src downstream region; src oncogene; SRC proto-oncogene, non-receptor tyrosine kinase; SRC proto-oncogene, non-receptor tyrosine kinase L homeolog; SRC proto-oncogene, non-receptor tyrosine kinase S homeolog; src.L; src.S; SRC1; src-1; src1-A; src-a; src-b; THC6; transforming protein; tyrosine kinase pp60c-src; tyrosine protein kinase c-src; tyrosine protein kinase pp60-c-src; tyrosine-protein kinase SRC-1; Unknown; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogen
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 20779, 6714, 83805
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG1
Antigen:
SRC
Classification:
Monoclonal
Concentration:
Lot-Specific
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
P05480, P12931, Q9WUD9
Gene Symbols:
SRC
Immunogen:
Clone (M259) was generated from a recombinant protein containing amino acids in the N-terminal region of human c-Src. This sequence has high homology to similar regions in rat and mouse c-Src.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Immunoprecipitation, Western Blot
Clone:
M259
Conjugate:
Unconjugated
Gene:
SRC
Gene Alias:
ASV; AW259666; csrc; c-SRC; c-src protein, C terminus; EC 2.7.10.2; fc54g04; Neuronal proto-oncogene tyrosine-protein kinase Src; non-tyrosine protein kinase; ORF; OTTHUMP00000174476; OTTHUMP00000174477; OTTHUMP00000174478; p60-Src; p60-Src-1; PP60C-SCR; pp60c-src; pp60src; pp60v-src; protein-tyrosine kinase; proto-oncogene c-Src; protooncogene SRC, Rous sarcoma; Proto-oncogene tyrosine-protein kinase Src; Rous sarcoma oncogene; RP5-823N20.1; sb:cb864; SDR; src; src downstream region; src oncogene; SRC proto-oncogene, non-receptor tyrosine kinase; SRC proto-oncogene, non-receptor tyrosine kinase L homeolog; SRC proto-oncogene, non-receptor tyrosine kinase S homeolog; src.L; src.S; SRC1; src-1; src1-A; src-a; src-b; THC6; transforming protein; tyrosine kinase pp60c-src; tyrosine protein kinase c-src; tyrosine protein kinase pp60-c-src; tyrosine-protein kinase SRC-1; Unknown; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogen
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
20779, 6714, 83805
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG1
Antigen: Syntaphilin
Classification: Monoclonal
Concentration: Lot-Specific
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: B5DF41, O15079, Q80U23
Gene Symbols: SNPH
Immunogen: Clone M371 was generated from a sequence corresponding to amino acids in the N-terminal region of human syntaphilin. This sequence has high homology to mouse and rat syntaphilin.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Western Blot
Clone: M371
Conjugate: Unconjugated
Gene: SNPH
Gene Alias: 6430515A01; AW045671; AW556958; AW743098; bA314N13.5; KIAA0374; mKIAA0374; Snph; Syntaphilin
Host Species: Mouse
Purification Method: Protein A
Regulatory Status: RUO
Gene ID (Entrez): 241727, 296267, 9751
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG1
Antigen:
Syntaphilin
Classification:
Monoclonal
Concentration:
Lot-Specific
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
B5DF41, O15079, Q80U23
Gene Symbols:
SNPH
Immunogen:
Clone M371 was generated from a sequence corresponding to amino acids in the N-terminal region of human syntaphilin. This sequence has high homology to mouse and rat syntaphilin.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Western Blot
Clone:
M371
Conjugate:
Unconjugated
Gene:
SNPH
Gene Alias:
6430515A01; AW045671; AW556958; AW743098; bA314N13.5; KIAA0374; mKIAA0374; Snph; Syntaphilin
Host Species:
Mouse
Purification Method:
Protein A
Regulatory Status:
RUO
Gene ID (Entrez):
241727, 296267, 9751
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG1
Antigen: TRPM7
Classification: Monoclonal
Concentration: 1 mg/mL
Formulation: PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.: Q923J1, Q925B3, Q96QT4
Gene Symbols: Trpm7
Immunogen: Clone M573 was generated from TRPM7 synthetic peptide (coupled to carrier) corresponding to amino acids in the extracellular region of human TRPM7. This site is well conserved in rat and mouse TRPM7, but has low homology to other TRPM family members.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Liquid
Applications: Western Blot
Clone: M573
Conjugate: Unconjugated
Gene: Trpm7
Gene Alias: 2310022G15Rik; 4833414K03Rik; 5033407O22Rik; ALSPDC; CHAK; CHAK1; Channel kinase 1; Channel-kinase 1; FLJ20117; long transient receptor potential channel 7; long transient receptor potential channel 7 {ECO:0000250; Ltpr7; LTRPC ion channel family member 7; LTRPC7; LTrpC-7; LTrpC7 {ECO:0000250; PubMed:11161216}; RGD:620053}; tr; transient receptor potential cation channel subfamily M member 7; transient receptor potential cation channel subfamily M member 7 {ECO:0000312; transient receptor potential cation channel, subfamily M, member 7; transient receptor potential M7; transient receptor potential-phospholipase C-interacting kinase; transient receptor potential-phospholipase C-interacting kinase {ECO:0000303; transient receptor potential-related protein, ChaK; TRMP7; TRP PLIK; Trpm7; trpm7 {ECO:0000312; TRPPLIK; Trp-plik; TRP-PLIK {ECO:0000303; UniProtKB:Q96QT4}
Host Species: Mouse
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 54822, 58800, 679906
Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
Isotype: IgG1
Antigen:
TRPM7
Classification:
Monoclonal
Concentration:
1 mg/mL
Formulation:
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.:
Q923J1, Q925B3, Q96QT4
Gene Symbols:
Trpm7
Immunogen:
Clone M573 was generated from TRPM7 synthetic peptide (coupled to carrier) corresponding to amino acids in the extracellular region of human TRPM7. This site is well conserved in rat and mouse TRPM7, but has low homology to other TRPM family members.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Liquid
Applications:
Western Blot
Clone:
M573
Conjugate:
Unconjugated
Gene:
Trpm7
Gene Alias:
2310022G15Rik; 4833414K03Rik; 5033407O22Rik; ALSPDC; CHAK; CHAK1; Channel kinase 1; Channel-kinase 1; FLJ20117; long transient receptor potential channel 7; long transient receptor potential channel 7 {ECO:0000250; Ltpr7; LTRPC ion channel family member 7; LTRPC7; LTrpC-7; LTrpC7 {ECO:0000250; PubMed:11161216}; RGD:620053}; tr; transient receptor potential cation channel subfamily M member 7; transient receptor potential cation channel subfamily M member 7 {ECO:0000312; transient receptor potential cation channel, subfamily M, member 7; transient receptor potential M7; transient receptor potential-phospholipase C-interacting kinase; transient receptor potential-phospholipase C-interacting kinase {ECO:0000303; transient receptor potential-related protein, ChaK; TRMP7; TRP PLIK; Trpm7; trpm7 {ECO:0000312; TRPPLIK; Trp-plik; TRP-PLIK {ECO:0000303; UniProtKB:Q96QT4}
Host Species:
Mouse
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
54822, 58800, 679906
Content And Storage:
-20° C, Avoid Freeze/Thaw Cycles
Isotype:
IgG1