CD86 Chimeric Recombinant Rabbit Monoclonal Antibody (PO.3), Invitrogen™

Description

• Specificity: This antibody is specific for murine CD86, an ∽80 kDa surface receptor of the B7 family of costimulatory molecules
• In addition to CD80, CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4)
• This interaction plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production and Th2-mediated Ig production
• CD86 is one of two ligands (the other CD80) for CTLA4 and CD28
• CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation
• Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance
• CD80 appears to play a role distinct from CD80 in T helper cell differentiation
• CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily
• The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4
• Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell
• Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response
• Alternative splicing results in two transcript variants encoding different isoforms of CD86
• Additional transcript variants have been described for CD86, but their full-length sequences have not been determined
• Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.