PIPA1003
Huntingtin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA1003-Each-of-1 | In Stock | ₹ 47,785.26 |
PIPA1003 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,785.26
GST (18%): ₹ 8,601.347
Total Price: ₹ 56,386.607
Antigen
Huntingtin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Htt
Gene Alias
AI256365; C430023I11Rik; Hd; HD protein; HD protein homolog; Hdh; HTT; Huntingtin; huntingtin (Huntington disease); Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; huntington disease protein; huntington disease protein homolog; IT15; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
15194, 3064
Content And Storage
-20°C
Form
Liquid
Applications
ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration
0.4 mg/mL
Formulation
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.
P42858, P42859
Gene Symbols
Htt
Immunogen
Synthetic peptide conjugated to KLH via cysteine corresponding to residues SDPAMDLND (544-552) of Human HTT.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Neoepitope antibodies distinguish smaller cleaved fragments or processed forms of proteins versus the intact full-length or precursor by using a designed peptide purification process to maximize immunoreactivity to a specific cleavage site
- Human HTT caspase cleavage sites generate fragment-specific forms of the protein
- Caspase-3/7 has been shown to generate cleavage sites at animo acids 513 and 552
- Caspase-2 cleaves at amino acid 552 and caspase-6 at amino acid 586
- Neo-specific antibody PA1-003 recognizes the 552 cleaved fragment without detecting the full-length form
- Huntingtin is a disease gene linked to Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons
- This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product
- HD is a mid-life onset autosomal dominant neurodegenerative disease that is characterized by psychiatric disorders, dementia, and involuntary movements (chorea), leading to death in 10-20 years.The huntingtin locus is large, spanning 180 kb and consisting of 67 exons
- The huntingtin gene is widely expressed and is required for normal development
- It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues
- The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed
- The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein.
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Antigen: Huntingtin
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Htt
Gene Alias: AI256365; C430023I11Rik; Hd; HD protein; HD protein homolog; Hdh; HTT; Huntingtin; huntingtin (Huntington disease); Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; huntington disease protein; huntington disease protein homolog; IT15; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Host Species: Rabbit
Purification Method: Affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 15194, 3064
Content And Storage: -20°C
Form: Liquid
Applications: ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: 0.4 mg/mL
Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.: P42858, P42859
Gene Symbols: Htt
Immunogen: Synthetic peptide conjugated to KLH via cysteine corresponding to residues SDPAMDLND (544-552) of Human HTT.
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
Huntingtin
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Htt
Gene Alias:
AI256365; C430023I11Rik; Hd; HD protein; HD protein homolog; Hdh; HTT; Huntingtin; huntingtin (Huntington disease); Huntingtin, myristoylated N-terminal fragment; Huntington disease gene homolog; huntington disease protein; huntington disease protein homolog; IT15; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Host Species:
Rabbit
Purification Method:
Affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
15194, 3064
Content And Storage:
-20°C
Form:
Liquid
Applications:
ELISA, Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
0.4 mg/mL
Formulation:
PBS with 1mg/mL BSA and 0.05% sodium azide
Gene Accession No.:
P42858, P42859
Gene Symbols:
Htt
Immunogen:
Synthetic peptide conjugated to KLH via cysteine corresponding to residues SDPAMDLND (544-552) of Human HTT.
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: ERp72
Classification: Polyclonal
Conjugate: Alexa Fluor 488
Gene: PDIA4
Gene Alias: AI987846; caBP2; Cai; calcium binding protein, intestinal; calcium-binding protein 2; EC 5.3.4.1; endoplasmic reticulum protein 72; endoplasmic reticulum resident protein 70; Endoplasmic reticulum resident protein 72; ER protein 70; ER protein 72; Erp70; Erp72; ERp-72; PDIA4; protein disu; protein disulfide isomerase A4; protein disulfide isomerase associated 4; protein disulfide isomerase family A member 4; protein disulfide isomerase family A, member 4; protein disulfide isomerase related protein (calcium-binding protein, intestinal-related); protein disulfide isomerase-associated 4; protein disulfide-isomerase A4; Protein ERp-72; testicular tissue protein Li 137
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12304, 9601
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Immunocytochemistry
Concentration: 1 mg/mL
Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Gene Accession No.: P08003, P13667
Gene Symbols: PDIA4
Immunogen: Synthetic peptide corresponding to residues K(629) F I E E H A T K L S R T K E E L(645) of humna ERp72
Quantity: 50 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
ERp72
Classification:
Polyclonal
Conjugate:
Alexa Fluor 488
Gene:
PDIA4
Gene Alias:
AI987846; caBP2; Cai; calcium binding protein, intestinal; calcium-binding protein 2; EC 5.3.4.1; endoplasmic reticulum protein 72; endoplasmic reticulum resident protein 70; Endoplasmic reticulum resident protein 72; ER protein 70; ER protein 72; Erp70; Erp72; ERp-72; PDIA4; protein disu; protein disulfide isomerase A4; protein disulfide isomerase associated 4; protein disulfide isomerase family A member 4; protein disulfide isomerase family A, member 4; protein disulfide isomerase related protein (calcium-binding protein, intestinal-related); protein disulfide isomerase-associated 4; protein disulfide-isomerase A4; Protein ERp-72; testicular tissue protein Li 137
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12304, 9601
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Immunocytochemistry
Concentration:
1 mg/mL
Formulation:
PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Gene Accession No.:
P08003, P13667
Gene Symbols:
PDIA4
Immunogen:
Synthetic peptide corresponding to residues K(629) F I E E H A T K L S R T K E E L(645) of humna ERp72
Quantity:
50 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: ERp72
Classification: Polyclonal
Conjugate: Alexa Fluor 647
Gene: PDIA4
Gene Alias: AI987846; caBP2; Cai; calcium binding protein, intestinal; calcium-binding protein 2; EC 5.3.4.1; endoplasmic reticulum protein 72; endoplasmic reticulum resident protein 70; Endoplasmic reticulum resident protein 72; ER protein 70; ER protein 72; Erp70; Erp72; ERp-72; PDIA4; protein disu; protein disulfide isomerase A4; protein disulfide isomerase associated 4; protein disulfide isomerase family A member 4; protein disulfide isomerase family A, member 4; protein disulfide isomerase related protein (calcium-binding protein, intestinal-related); protein disulfide isomerase-associated 4; protein disulfide-isomerase A4; Protein ERp-72; testicular tissue protein Li 137
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 12304, 9601
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Immunocytochemistry
Concentration: 1 mg/mL
Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Gene Accession No.: P08003, P13667
Gene Symbols: PDIA4
Immunogen: Synthetic peptide corresponding to residues K(629) F I E E H A T K L S R T K E E L(645) of humna ERp72
Quantity: 50 μL
Primary or Secondary: Primary
Target Species: Human, Mouse
Product Type: Antibody
Isotype: IgG
Antigen:
ERp72
Classification:
Polyclonal
Conjugate:
Alexa Fluor 647
Gene:
PDIA4
Gene Alias:
AI987846; caBP2; Cai; calcium binding protein, intestinal; calcium-binding protein 2; EC 5.3.4.1; endoplasmic reticulum protein 72; endoplasmic reticulum resident protein 70; Endoplasmic reticulum resident protein 72; ER protein 70; ER protein 72; Erp70; Erp72; ERp-72; PDIA4; protein disu; protein disulfide isomerase A4; protein disulfide isomerase associated 4; protein disulfide isomerase family A member 4; protein disulfide isomerase family A, member 4; protein disulfide isomerase related protein (calcium-binding protein, intestinal-related); protein disulfide isomerase-associated 4; protein disulfide-isomerase A4; Protein ERp-72; testicular tissue protein Li 137
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
12304, 9601
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Immunocytochemistry
Concentration:
1 mg/mL
Formulation:
PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Gene Accession No.:
P08003, P13667
Gene Symbols:
PDIA4
Immunogen:
Synthetic peptide corresponding to residues K(629) F I E E H A T K L S R T K E E L(645) of humna ERp72
Quantity:
50 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Product Type:
Antibody
Isotype:
IgG
Antigen: KDEL
Classification: Polyclonal
Conjugate: Alexa Fluor 488
Gene: Hsp90b1
Gene Alias: 78 kDa glucose-regulated protein; 8030486F04Rik; 94 kDa glucose-regulated protein; 94 kDa glucose-regulated protein {ECO:0000250; AL022860; AU019543; AW215843; baffled; Binding-immunoglobulin protein; BiP; D2Wsu141e; D2Wsu17e; ECGP; Endoplasmic reticulum chaperone BiP; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; endoplasmic reticulum resident protein 58; Endoplasmic reticulum resident protein 99; Endoplasmin; endoplasmin {ECO:0000250; endothelial cell (HBMEC) glycoprotein; EP58; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; epididymis secretory sperm binding protein Li 89n; ER lumen protein retaining receptor 1; ER lumen protein-retaining receptor 1; ER protein 58; ERD2; Erd2.1; ERp58; ERp99; glucose regulated protein, 78 kDa; glucose-regulated protein; glucose-regulated protein, 78kDa; gp96; gp96 homolog; GRP 78; Grp78; GRP-78; GRP94; GRP-94; HDEL; heat shock 70 kDa protein 5; heat shock 70kD protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock 70kDa protein 5 (glucose-regulated protein); heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 5; Heat shock protein 70 family protein 5; heat shock protein 90 beta family member 1; heat shock protein 90 kDa beta member 1; heat shock protein 90 kDa beta member 1 {ECO:0000250; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90, beta, member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein family A (Hsp70) member 5; Heat shock protein family A member 5; HEL35; HEL-S-125m; HEL-S-89n; Hsce70; HSP70 family protein 5; Hsp90b1; hsp90b1 {ECO:0000250; HSPA5; I79_019946; I79_020931; Immunoglobulin heavy chain-binding protein; KDEL; KDEL (Lys-Asp-Glu-Leu) containing 1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL motif containing 1; KDEL motif-containing 1; KDEL motif-containing protein 1; KDEL receptor 1; KDEL1; KDELC1; KDELR1; Lys-Asp-Glu-Leu; mBiP; MIF2; PM23; POGLUT2; Polymorphic tumor rejection antigen 1; Protein O-glucosyltransferase 2; Protein O-xylosyltransferase POGLUT2; Putative MAPK-activating protein PM23; RP23-446N16.1; Sez7; SEZ-7; Steroidogenesis-activator polypeptide; stress-inducible tumor rejection antigen gp96; TA-3; Targ2; Tra1; Tra-1; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; tumor rejection antigen 1; Tumor rejection antigen gp96; UniProtKB:P08113}; UNQ1910/PRO4357; XAP-1 antigen
Host Species: Rabbit
Purification Method: Antigen affinity chromatography
Regulatory Status: RUO
Gene ID (Entrez): 100689305, 100750912, 100773331, 10945, 14828, 22027, 25617, 3309, 361577, 362862, 68137, 7184
Content And Storage: 4° C, store in dark, DO NOT FREEZE!
Form: Liquid
Applications: Immunocytochemistry
Concentration: 1 mg/mL
Formulation: PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Gene Accession No.: P06761, P08113, P11021, P14625, P20029, P24390, Q569A6, Q66HD0, Q99JH8
Gene Symbols: Hsp90b1, HSPA5, Kdelr1
Immunogen: Synthetic peptide corresponding to residues C T(643) G E E D T S E K D E L(654) of rat GRP94
Quantity: 50 μL
Primary or Secondary: Primary
Target Species: Hamster, Human, Mouse, Rat
Product Type: Antibody
Isotype: IgG
Antigen:
KDEL
Classification:
Polyclonal
Conjugate:
Alexa Fluor 488
Gene:
Hsp90b1
Gene Alias:
78 kDa glucose-regulated protein; 8030486F04Rik; 94 kDa glucose-regulated protein; 94 kDa glucose-regulated protein {ECO:0000250; AL022860; AU019543; AW215843; baffled; Binding-immunoglobulin protein; BiP; D2Wsu141e; D2Wsu17e; ECGP; Endoplasmic reticulum chaperone BiP; endoplasmic reticulum lumenal Ca(2+)-binding protein grp78; endoplasmic reticulum resident protein 58; Endoplasmic reticulum resident protein 99; Endoplasmin; endoplasmin {ECO:0000250; endothelial cell (HBMEC) glycoprotein; EP58; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; epididymis secretory sperm binding protein Li 89n; ER lumen protein retaining receptor 1; ER lumen protein-retaining receptor 1; ER protein 58; ERD2; Erd2.1; ERp58; ERp99; glucose regulated protein, 78 kDa; glucose-regulated protein; glucose-regulated protein, 78kDa; gp96; gp96 homolog; GRP 78; Grp78; GRP-78; GRP94; GRP-94; HDEL; heat shock 70 kDa protein 5; heat shock 70kD protein 5; heat shock 70kD protein 5 (glucose-regulated protein, 78kD); heat shock 70kDa protein 5 (glucose-regulated protein); heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 5; Heat shock protein 70 family protein 5; heat shock protein 90 beta family member 1; heat shock protein 90 kDa beta member 1; heat shock protein 90 kDa beta member 1 {ECO:0000250; heat shock protein 90, beta (Grp94), member 1; heat shock protein 90, beta, member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein family A (Hsp70) member 5; Heat shock protein family A member 5; HEL35; HEL-S-125m; HEL-S-89n; Hsce70; HSP70 family protein 5; Hsp90b1; hsp90b1 {ECO:0000250; HSPA5; I79_019946; I79_020931; Immunoglobulin heavy chain-binding protein; KDEL; KDEL (Lys-Asp-Glu-Leu) containing 1; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1; KDEL endoplasmic reticulum protein retention receptor 1; KDEL motif containing 1; KDEL motif-containing 1; KDEL motif-containing protein 1; KDEL receptor 1; KDEL1; KDELC1; KDELR1; Lys-Asp-Glu-Leu; mBiP; MIF2; PM23; POGLUT2; Polymorphic tumor rejection antigen 1; Protein O-glucosyltransferase 2; Protein O-xylosyltransferase POGLUT2; Putative MAPK-activating protein PM23; RP23-446N16.1; Sez7; SEZ-7; Steroidogenesis-activator polypeptide; stress-inducible tumor rejection antigen gp96; TA-3; Targ2; Tra1; Tra-1; transforming growth factor alpha regulated gene 2; tumor rejection antigen (gp96) 1; tumor rejection antigen 1; Tumor rejection antigen gp96; UniProtKB:P08113}; UNQ1910/PRO4357; XAP-1 antigen
Host Species:
Rabbit
Purification Method:
Antigen affinity chromatography
Regulatory Status:
RUO
Gene ID (Entrez):
100689305, 100750912, 100773331, 10945, 14828, 22027, 25617, 3309, 361577, 362862, 68137, 7184
Content And Storage:
4° C, store in dark, DO NOT FREEZE!
Form:
Liquid
Applications:
Immunocytochemistry
Concentration:
1 mg/mL
Formulation:
PBS with 1mg/mL BSA and 0.05% sodium azide; pH 7.4
Gene Accession No.:
P06761, P08113, P11021, P14625, P20029, P24390, Q569A6, Q66HD0, Q99JH8
Gene Symbols:
Hsp90b1, HSPA5, Kdelr1
Immunogen:
Synthetic peptide corresponding to residues C T(643) G E E D T S E K D E L(654) of rat GRP94
Quantity:
50 μL
Primary or Secondary:
Primary
Target Species:
Hamster, Human, Mouse, Rat
Product Type:
Antibody
Isotype:
IgG