Levo-alpha-Acetylmethadol Polyclonal Antibody, Invitrogen™

Description

• PA1-75235 specifically detects Levo-alpha-Acetylmethadol
• PA1-75235 has been successfully used in ELISA applications
• The PA1-75235 immunogen is LAAM(p)-BSA
• Levomethadyl Acetate is only found in individuals that have used or taken this drug
• It is a narcotic analgesic with a long onset and duration of action
• It is used mainly in the treatment of narcotic dependence
• [PubChem]Opiate receptors (Mu, Kappa, Delta) are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins
• Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex
• As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase
• Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited
• Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon
• Levomethadyl acetate effectively opens calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist), resulting in hyperpolarization and reduced neuronal excitability
• [National Center for Biotechnology Information
• PubChem Compound Database; CID=15130].