PIPA5101018

Phospho-HSF1 (Ser326) Polyclonal Antibody, Invitrogen™

Manufacturer: Thermo Scientific

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Pack Size SKU Availability Price
Each of 1 PIPA5101018-Each-of-1 In Stock ₹ 45,988.50

PIPA5101018 - Each of 1

₹ 45,988.50

In Stock

Quantity

1

Base Price: ₹ 45,988.50

GST (18%): ₹ 8,277.93

Total Price: ₹ 54,266.43

Antigen

Phospho-HSF1 (Ser326)

Classification

Polyclonal

Conjugate

Unconjugated

Gene

Hsf1

Gene Alias

AA960185; heat shock factor 1; heat shock factor 2; Heat shock factor protein 1; Heat shock transcription factor 1; heat shock transcription factor 1 alpha isoform; heat shock transcription factor 1 beta isoform; heat shock transcription factor 1 gammaalpha isoform; heat shock transcription factor 1 gammabeta isoform; HSF; HSF 1; Hsf1; Hsf1alpha; Hsf1beta; Hsf1gammaalpha; Hsf1gammabeta; HSTF 1; HSTF1

Host Species

Rabbit

Purification Method

sequential chromatography

Regulatory Status

RUO

Gene ID (Entrez)

3297, 79245

Content And Storage

-20°C

Form

Liquid

Applications

Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration

1 mg/mL

Formulation

PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.

Q00613

Gene Symbols

Hsf1

Immunogen

A synthesized peptide derived from human HSF1(Accession Q00613), corresponding to amino acid residues around phosphorylated Ser326.

Quantity

100 μL

Primary or Secondary

Primary

Target Species

Human, Rat

Product Type

Antibody

Isotype

IgG

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Description

  • Antibody detects endogenous levels of HSF1 only when phosphorylated at Ser326
  • All organisms respond to elevated temperatures and a variety of environmental stresses by rapid synthesis of heat shock RNAs and proteins
  • The regulation of heat shock gene transcription is mediated by the transcriptional activator, heat shock factor (HSF), which binds to heat shock response elements (HSEs)
  • These HSEs are found as three repeats of a 5-nucleotide {nGAAn} module, arranged in alternating orientation and present upstream of all heat shock genes
  • The HSEs are highly conserved among species yet HSF purified from yeast, Drosophila and human have different molecular weights and the proteins do not show significant immunological cross reaction
  • Two HSFs have been identified in human cells, HSF1 and HSF2, which bind to the same HSEs and have 38% sequence identity
  • These factors are activated by distinct stimuli, HSF1 is responsive to classical stress signals such as heat, heavy metals and oxidative reagents, whereas HSF2 is activated during hemin-mediated differentiation of human erythroleukemia cells
  • HSF1 exists constitutively in the cytoplasm and the nucleus of unstressed cells as a monomer which lacks DNA binding activity
  • Through an unknown signal generated during stress, HSF1 becomes activated to a nuclear localized, trimeric state which binds to DNA
  • The phosphorylation of HSF1 is necessary for maximal transcription of heat shock genes.

Compare Similar Items

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Img

Thermo Scientific

PIPA5101018

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Antigen:
Phospho-HSF1 (Ser326)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
Hsf1

Gene Alias:
AA960185; heat shock factor 1; heat shock factor 2; Heat shock factor protein 1; Heat shock transcription factor 1; heat shock transcription factor 1 alpha isoform; heat shock transcription factor 1 beta isoform; heat shock transcription factor 1 gammaalpha isoform; heat shock transcription factor 1 gammabeta isoform; HSF; HSF 1; Hsf1; Hsf1alpha; Hsf1beta; Hsf1gammaalpha; Hsf1gammabeta; HSTF 1; HSTF1

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
3297, 79245

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
Q00613

Gene Symbols:
Hsf1

Immunogen:
A synthesized peptide derived from human HSF1(Accession Q00613), corresponding to amino acid residues around phosphorylated Ser326.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5101019

--


Antigen:
Phospho-PAK1/2/3 (Ser144, Ser141, Ser139)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
PAK2

Gene Alias:
5330420P17Rik; A130002K10Rik; activated protein kinase alpha; ADRB2; adriamycin resistance-associated; AI836325; Alpha-PAK; ARA; AW045634; Beta-PAK; bPAK; CDC42/RAC effector kinase PAK-A; CDC42/RAC effector kinase PAK-B; CDKN1A; C-t-PAK2; D16Ertd269e; EC 2.7.11.1; gamma pak; gamma-PAK; hPAK3; kinase PAK1; mKIAA4182; MRX30; MRX47; oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 1; p21 (CDKN1A)-activated kinase 2; p21 (CDKN1A)-activated kinase 3; p21 (RAC1) activated kinase 1; p21 (RAC1) activated kinase 2; p21 (RAC1) activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 3; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p21-activated kinase 1; p21-activated kinase 2; p21-activated kinase 3; p27; p34; p58; p65-PAK; p68-PAK; PAK 1; PAK alpha; PAK beta; PAK gamma; Pak1; PAK-1; Pak2; PAK-2; PAK-2p27; PAK-2p34; PAK3; PAK-3; PAK3beta; PAK65; Pak65alpha; Pak65beta; Paka; PAKalpha; Pakb; PAKgamma; Protein kinase MUK2; S6/H4 kinase; Serine/threonine-protein kinase PAK 1; serine/threonine-protein kinase PAK 2; Serine/threonine-protein kinase PAK 3; STE20 homolog, yeast; Stk4

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
18479, 18481, 224105, 29431, 29432, 29433, 5058, 5062, 5063

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
O75914, O88643, P35465, Q13153, Q13177, Q61036, Q62829, Q64303, Q8CIN4

Gene Symbols:
Pak1, PAK2, PAK3

Immunogen:
A synthesized peptide derived from human PAK3(Accession O75914), corresponding to amino acid residues around phosphorylated Ser139.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5101020

--


Antigen:
Phospho-RSK1 (Thr359, Ser363)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
RPS6KA1

Gene Alias:
90 kDa ribosomal protein S6 kinase 1; dJ590P13.1 (ribosomal protein S6 kinase, 90kD, polypeptide 1); hu-1; MAP kinase-activated protein kinase 1; MAP kinase-activated protein kinase 1a; MAPK-activated protein kinase 1; MAPK-activated protein kinase 1a; MAPKAP kinase 1; MAPKAP kinase 1a; MAPKAPK-1; mapkapk1a; MAPKAPK-1a; p90Rsk; P90-RSK; p90-RSK 1; p90Rsk1; p90-Rsk1; p90S6K; pp90RSK1; ribosomal protein S6 kinase 2 alpha; ribosomal protein S6 kinase 2 beta; ribosomal protein S6 kinase a, polypeptide 1; ribosomal protein S6 kinase A1; ribosomal protein S6 kinase A1 L homeolog; ribosomal protein S6 kinase alpha 1; Ribosomal protein S6 kinase alpha-1; Ribosomal protein S6 kinase II alpha; ribosomal protein S6 kinase II beta; ribosomal protein S6 kinase polypeptide 1; ribosomal protein S6 kinase, 90kD, polypeptide 1; Ribosomal protein S6 kinase, 90kD, 1; ribosomal protein S6 kinase, 90kDa, polypeptide 1; ribosomal protein S6 kinase, 90kDa, polypeptide 1 L homeolog; ribosomal protein S6 kinas

Host Species:
Rabbit

Purification Method:
sequential chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
20111, 6195, 81771

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
P18653, Q15418, Q63531

Gene Symbols:
RPS6KA1

Immunogen:
A synthesized peptide derived from human RPS6KA1(Accession Q15418), corresponding to amino acid residues around phosphorylated Thr359.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG

Img

Thermo Scientific

PIPA5101022

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Antigen:
PIK3R2

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
PIK3R2

Gene Alias:
MPPH; MPPH1; p85; P85B; p85beta; p85-BETA; phosphatidylinositol 3-kinase; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase regulartory subunit polypeptide 2; phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase, regulartory subunit, polypeptide 2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); phosphoinositide-3-kinase regulatory subunit 2; phosphoinositide-3-kinase regulatory subunit beta; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta); PI3K; PI3K regulatory subunit beta; PI3-kinase p85 subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PIK3R2; ptdIns-3-kinase p85-beta; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta

Host Species:
Rabbit

Purification Method:
Affinity chromatography

Regulatory Status:
RUO

Gene ID (Entrez):
18709, 29741, 5296

Content And Storage:
-20°C

Form:
Liquid

Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot

Concentration:
1 mg/mL

Formulation:
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4

Gene Accession No.:
O00459, O08908, Q63788

Gene Symbols:
PIK3R2

Immunogen:
A synthesized peptide derived from human PIK3R2(Accession O00459), corresponding to amino acid residues Y577-I627.

Quantity:
100 μL

Primary or Secondary:
Primary

Target Species:
Human, Mouse, Rat

Product Type:
Antibody

Isotype:
IgG